496056-24-7

Basic information

• Product Name: 4-(2-METHYL-BENZYL)-PIPERIDINE
• Synonyms: 4-(2-METHYL-BENZYL)-PIPERIDINE;4-[(2-METHYLPHENYL)METHYL]-PIPERIDINE
• CAS NO: 496056-24-7
• Molecular Formula: C₁₃H₁₉N
• Molecular Weight: 189.3
• Mol File: 496056-24-7.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 301°C at 760 mmHg
• Flash Point: 139.2°C
• Appearance: /
• Density: 0.96g/cm³
• Vapor Pressure: 0.00108mmHg at 25°C
• Refractive Index: 1.525
• CAS DataBase Reference: 4-(2-METHYL-BENZYL)-PIPERIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(2-METHYL-BENZYL)-PIPERIDINE(496056-24-7)
• EPA Substance Registry System: 4-(2-METHYL-BENZYL)-PIPERIDINE(496056-24-7)

Safety Data

• Hazardous Substances Data: 496056-24-7(Hazardous Substances Data)

Usage

InChI:InChI=1/C13H19N/c1-11-4-2-3-5-13(11)10-12-6-8-14-9-7-12/h2-5,12,14H,6-10H2,1H3

Upstream product

• 932-31-0 ortho-tolylmagnesium bromide 
• 872-85-5 pyridine-4-carbaldehyde 
• 112064-22-9 α-(2-methylphenyl)-4-pyridinemethanol 

Relevant articles and documents

Convenient, benign and scalable synthesis of 2- and 4-substituted benzylpiperidines

A short, scalable and environmentally benign synthesis of 2- and 4-substituted benzylpiperidines has been developed. The method is based on the temperature-programmed consecutive deoxygenation and heteroaromatic ring saturation of aryl(pyridin-2-yl)- and aryl(pyridin-4-yl)methanols and aryl(pyridin-4-yl)methanones in the presence of Pd/C catalyst. The crucial roles of the temperature, the acidity and the substrate structure in the change of selectivity have been demonstrated by isolation of several substituted aryl(piperidine)methanols. The carbinols and ketones were prepared from commercially available pyridinecarbaldehydes or 4-cyanopyridine and substituted bromobenzenes via organometallic intermediates. Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2004.