496775-62-3 Usage
Uses
Used in Pharmaceutical Industry:
Unii-4U07F515lg is used as a pharmaceutical agent for the treatment of chemotherapy-induced thrombocytopenia and immune thrombocytopenic purpura. It helps in increasing the platelet count in patients undergoing chemotherapy, which can cause a decrease in platelets due to the toxic effects of the treatment.
Used in Cosmetics and Personal Care Industry:
Glycerol is used as a humectant in the cosmetics and personal care industry. It helps to retain moisture in the skin, hair, and other personal care products, providing hydration and improving the overall texture and appearance.
Used in Food and Beverage Industry:
In the food and beverage industry, Unii-4U07F515lg is used as a sweetener, preservative, and moisturizer. It helps to improve the texture, taste, and shelf life of various food products, including baked goods, confectionery, and beverages.
Used in Industrial Applications:
Glycerol is used in various industrial applications, such as in the production of nitroglycerin, which is an essential component of explosives and propellants. It is also used as a solvent in the manufacturing of inks, dyes, resins, and other chemicals.
Used in Energy Production:
In the energy sector, glycerol is used as a feedstock for the production of biofuels, such as biodiesel. It can also be used as a fuel additive to improve the combustion efficiency and reduce emissions in internal combustion engines.
Used in Agriculture:
Unii-4U07F515lg is used in the agriculture industry as a component in the formulation of fertilizers and soil conditioners. It helps to improve soil structure, water retention, and nutrient availability for plants.
Clinical Use
Eltrombopag olamine, a thrombopoietin receptor (TpoR) agonist,
was approved in late 2008 for the once-daily, oral short-term and long-term treatment of adult patients with previously treated
chronic idiopathic thrombocytopenic purpura (ITP). It is the first
small-molecule TpoR agonist and was launched in the U.S. for this
indication in 2009 by GlaxoSmithKline (GSK). Because eltrombopag
is a small molecule, the drug is administered orally and has
a reduced potential for causing an immune system reaction
versus alternative protein-based therapies. In 2010, eltrombopag
was approved in Europe for the long-term treatment of adult
patients with previously treated chronic ITP.
Synthesis
The synthesis began
with the nitration of 2-bromophenol (39) with sodium nitrate
and sulfuric acid in water at 10°C to give 2-bromo-6-nitrophenol
(40) in 25% yield, which was methylated using methyl iodide and
potassium carbonate in refluxing acetone providing 2-bromo-
6-nitroanisole (41) in 76% yield (the Scheme).40 Suzuki coupling of
compound 41 with 3-carboxyphenyl boronic acid with Pd(PPh3)4
and 2 M sodium carbonate in refluxing dioxane gave 20-methoxy-
30-nitrobiphenyl-3-carboxylic acid (42) in 47% yield as a tan
powder. Demethylation using 48% HBr (aq) in refluxing acetic acid
resulted in a 79% yield of 20-hydroxy-30-nitrobiphenyl-3-carboxylic
acid (43). The nitro group of compound 43 was reduced via catalytic
hydrogenation at 50 psi at room temperature over Pd/C in
mixed ethanol/3 M aq NaOH solution to give 30-amino-20-hydroxybiphenyl-
3-carboxylic acid (44) in quantitative yield. The
intermediate 1-(3,4-dimethylphenyl)-3-methyl-2,5-dihydro-1Hpyrazol-
5-one (47) was prepared by condensing of 3,4-dimethylphenyl-
hydrazine 45 with ethyl acetoacetate 46 with sodium
acetate in refluxing acetic acid in 76% yield. Treatment of (44) with
sodium nitrite in 1 M HCl at 5°C, followed by condensation with
1-(3,4-dimethylphenyl)-3-methyl-2,5-dihydro-1H-pyrazol-5-one
(47) at a constant pH of 7–8 via the addition of sodium bicarbonate
and ethanol afforded eltrombopag in 32% yield. Finally, eltrombopag
was treated with hydroxyl ethylamine to give eltrombopag
olamine (VIII).
Check Digit Verification of cas no
The CAS Registry Mumber 496775-62-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 4,9,6,7,7 and 5 respectively; the second part has 2 digits, 6 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 496775-62:
(8*4)+(7*9)+(6*6)+(5*7)+(4*7)+(3*5)+(2*6)+(1*2)=223
223 % 10 = 3
So 496775-62-3 is a valid CAS Registry Number.
InChI:InChI=1/C25H22N4O4.2C2H7NO/c1-14-10-11-19(12-15(14)2)29-24(31)22(16(3)28-29)27-26-21-9-5-8-20(23(21)30)17-6-4-7-18(13-17)25(32)33;2*3-1-2-4/h4-13,26,30H,1-3H3,(H,32,33);2*4H,1-3H2/b27-22-;;
