49713-56-6

Basic information

• Product Name: 4-Chloro-6-(trifluoromethyl)quinoline
• Synonyms: 4-Chloro-6-(trifluoromethyl)quinoline 98%;4-Chloro-6-(trifluoromethyl)quinoline98%;4-Chloro-6-(trifluoroMethyl)quinolline;4-Chloro-6-(trifluoromethyl)-1-azanaphthalene;4-CHLORO-6-(TRIFLUOROMETHYL)QUINOLINE;BUTTPARK 14\01-63
• CAS NO: 49713-56-6
• Molecular Formula: C₁₀H₅ClF₃N
• Molecular Weight: 231.6
• Product Categories: Quinoline&Isoquinoline
• Mol File: 49713-56-6.mol
• Article Data: 7

Chemical Properties

• Melting Point: 48°C
• Boiling Point: 265.51 °C at 760 mmHg
• Flash Point: 114.377 °C
• Appearance: /
• Density: 1.428 g/cm³
• Vapor Pressure: 0.174mmHg at 25°C
• Refractive Index: 1.359
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: 2.45±0.16(Predicted)
• CAS DataBase Reference: 4-Chloro-6-(trifluoromethyl)quinoline(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Chloro-6-(trifluoromethyl)quinoline(49713-56-6)
• EPA Substance Registry System: 4-Chloro-6-(trifluoromethyl)quinoline(49713-56-6)

Safety Data

• Hazard Codes: Xi,T
• Statements: 36/37/38-36-25
• Safety Statements: 26-36/37/39-45
• RIDADR: UN 2811 6.1 / PGIII
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 49713-56-6(Hazardous Substances Data)

Usage

General Description

4-Chloro-6-(trifluoromethyl)quinoline is a chemical compound with the molecular formula C10H5ClF3N. It is a quinoline derivative with a chlorine atom and a trifluoromethyl group attached to the quinoline ring. 4-Chloro-6-(trifluoromethyl)quinoline is commonly used as an intermediate in the synthesis of pharmaceuticals and agrochemicals. It is also used as a building block in organic synthesis and in the development of new materials. 4-Chloro-6-(trifluoromethyl)quinoline may also have potential applications in the field of medicinal chemistry and drug discovery. Overall, it is a versatile and important chemical that has various industrial and scientific uses.

InChI:InChI=1/C3H5F2NO/c1-3(4,5)2(6)7/h1H3,(H2,6,7)

Upstream product

• 40107-07-1 4-chloro-6-iodo-quinoline 
• 81290-20-2 (trifluoromethyl)trimethylsilane 
• 641993-21-7 4-oxo-6-(trifluoromethyl)-1,4-dihydroquinoline-3-carboxylic acid 
• 455-14-1 4-trifluoromethylphenylamine 
• 49713-51-1 C₁₀H₆F₃NO 
• 71083-01-7 ethyl 4-oxo-6-(trifluoromethyl)-1,4-dihydroquinoline-3-carboxylate 
• 681472-89-9 2,2-dimethyl-5-[[4-(trifluoromethyl)anilino]methylene]-1,3-dioxane-4,6-dione 
• 49713-51-1 4-hydroxy-6-(trifluoromethyl)quinoline 

Relevant articles and documents

A Selective and Orally Bioavailable Quinoline-6-Carbonitrile-Based Inhibitor of CDK8/19 Mediator Kinase with Tumor-Enriched Pharmacokinetics

Senexins are potent and selective quinazoline inhibitors of CDK8/19 Mediator kinases. To improve their potency and metabolic stability, quinoline-based derivatives were designed through a structure-guided strategy based on the simulated drug–target dockin

CYCLOALKYL ACID DERIVATIVE, PREPARATION METHOD THEREOF, AND PHARMACEUTICAL APPLICATION THEREOF

The present invention relates to a cycloalkyl acid derivative, a preparation method thereof, and a pharmaceutical application thereof, and in particular, the present invention relates to a cycloalkyl acid derivative represented by general formula (I) and a medical salt thereof, a preparation method thereof, and an application of the cycloalkyl acid derivative and the medical salt thereof as URAT1 inhibitors, and particularly as therapeutic agents for diseases related to an abnormal uric acid level, wherein definitions of substituent groups in general formula (I) are the same as definitions in the specifications.

Efficient copper-catalyzed trifluoromethylation of aromatic and heteroaromatic iodides: The beneficial anchoring effect of borates

Efficient copper-catalyzed trifluoromethylation of aromatic iodides was achieved with TMSCF3 in the presence of trimethylborate. The Lewis acid was used to anchor the in situ generated trifluoromethyl anion and suppress its rapid decomposition. Broad applicability of the new trifluoromethylating reaction was demonstrated in the functionalization of different aromatic and heteroaromatic iodides.