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4999-76-2

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4999-76-2 Usage

Chemical Properties

White Solid

Uses

3,17β-Diacetoxy-3,5-estradiene can be used in the preparation of various steroids.

Check Digit Verification of cas no

The CAS Registry Mumber 4999-76-2 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 4,9,9 and 9 respectively; the second part has 2 digits, 7 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 4999-76:
(6*4)+(5*9)+(4*9)+(3*9)+(2*7)+(1*6)=152
152 % 10 = 2
So 4999-76-2 is a valid CAS Registry Number.

4999-76-2SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name [(8R,9S,10R,13S,14S,17R)-3-acetyloxy-13-methyl-1,2,7,8,9,10,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-17-yl] acetate

1.2 Other means of identification

Product number -
Other names (17|A)-Estra-3,5-diene-3,17-diol 3,17-Diacetate

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:4999-76-2 SDS

4999-76-2Relevant articles and documents

BILE ACIDS AND STEROIDS. 28. THIOSTEROIDS. 13. FURTHER STUDY ON

TAKEDA,KOMENO,ISHIHARA

, p. 1433 - 1439 (1964)

-

Preparation method for 3,5-estradiene-3,17beta-diacetate

-

Paragraph 0013; 0014, (2017/12/13)

The invention relates to a preparation method for 3,5-estradiene-3,17beta-diacetate. The preparation method comprises the following steps: sequentially adding nandrolone, p-toluenesulfonic acid monohydrate, isopropyl acetate and magneton No. 15 into a reactor, introducing condensed water, carrying out a heating reaction in an oil-bath pot and slowing adding isopropenyl acetate when reflux condensation of the obtained system begins; after completion of a reaction, carrying out evaporation to remove a solvent; cooling the system, adding pyridine, and adding isopropanol drop by drop until a white solid product is precipitated; carrying out low-temperature cooling and pumping filtration and then carrying out cleaning with cold isopropanol; collecting the white solid product and then carrying out drying so as to obtain a pure 3,5-estradiene-3,17beta-diacetate product. According to the invention, nandrolone is used as a substrate and a one-pot method is employed for carbonyl and hydroxyl acetylation protection so as to synthesize the product; the method is simple in process, mild in conditions and friendly to environment and has yield of up to 85%; and the synthesized product has critical application value in the fields of medicines, veterinary drugs and pesticides and is an important pro-drug for tibolone.

Stereoselective synthesis of some methyl-substituted steroid hormones and their in vitro cytotoxic activity against human gastric cancer cell line MGC-803

Li, Chun,Qiu, Wenwei,Yang, Zhengfeng,Luo, Jian,Yang, Fan,Liu, Mingyao,Xie, Juan,Tang, Jie

experimental part, p. 859 - 869 (2010/10/18)

A series of 3-, 7-, 15-, and 16-methyl-substituted steroid analogs were synthesized via a highly stereoselective 1,6-conjugate addition. Under the catalysis of CuBr, AlMe3 reacted with four steroid dienone precursors to afford either the corresponding α-epimer of C-3 and C-7 methyl-substituted steroids as the major products, and the ratio of α/β was up to 10/1. No β-epimer has been detected for methyl addition at C-16. However, under the same reaction conditions, enantioselective methyl addition at C-15 afforded the 15β-epimer as the major product. The preliminary SAR analysis showed that the methyl substituents at C-7α and C-15β positions lead to a dramatical increase in potency against human gastric cancer cell line MGC-803.

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