Welcome to LookChem.com Sign In|Join Free

CAS

  • or

50-84-0

Post Buying Request

50-84-0 Suppliers

Recommended suppliersmore

  • Product
  • FOB Price
  • Min.Order
  • Supply Ability
  • Supplier
  • Contact Supplier

50-84-0 Usage

Chemical Properties

white powder

Uses

Different sources of media describe the Uses of 50-84-0 differently. You can refer to the following data:
1. 2,4-Dichlorobenzoic Acid is a di-halogenated benzoic acid derivative and an intermediate in the synthesis of spirodiclofen (S682990), a tetronic acid acaricide fungicide used in controlling red mites.
2. 2,4-Dichlorobenzoic acid is used as reagent during the synthesis of pyrimido[2?,1?:2,3]thiazolo[4,5-b]quinoxaline derivatives. It is also used as starting reagent during the synthesis of 1-(substituted)-1,4-dihydro-6-nitro-4-oxo-7-(sub-secondary amino)-quinoline-3-carboxylic acids.

Definition

ChEBI: A chlorobenzoic acid that is benzoic acid in which the ring hydrogens at positions 2 and 4 are substituted by chloro groups.

General Description

White to slightly yellowish powder.

Air & Water Reactions

Insoluble in water.

Reactivity Profile

2,4-Dichlorobenzoic acid is a halogenated carboxylic acid. Carboxylic acids donate hydrogen ions if a base is present to accept them. They react in this way with all bases, both organic (for example, the amines) and inorganic. Their reactions with bases, called "neutralizations", are accompanied by the evolution of substantial amounts of heat. Neutralization between an acid and a base produces water plus a salt. Carboxylic acids with six or fewer carbon atoms are freely or moderately soluble in water; those with more than six carbons are slightly soluble in water. Soluble carboxylic acid dissociate to an extent in water to yield hydrogen ions. The pH of solutions of carboxylic acids is therefore less than 7.0. Many insoluble carboxylic acids react rapidly with aqueous solutions containing a chemical base and dissolve as the neutralization generates a soluble salt. Carboxylic acids in aqueous solution and liquid or molten carboxylic acids can react with active metals to form gaseous hydrogen and a metal salt. Such reactions occur in principle for solid carboxylic acids as well, but are slow if the solid acid remains dry. Even "insoluble" carboxylic acids may absorb enough water from the air and dissolve sufficiently in 2,4-Dichlorobenzoic acid to corrode or dissolve iron, steel, and aluminum parts and containers. Carboxylic acids, like other acids, react with cyanide salts to generate gaseous hydrogen cyanide. The reaction is slower for dry, solid carboxylic acids. Insoluble carboxylic acids react with solutions of cyanides to cause the release of gaseous hydrogen cyanide. Flammable and/or toxic gases and heat are generated by the reaction of carboxylic acids with diazo compounds, dithiocarbamates, isocyanates, mercaptans, nitrides, and sulfides. Carboxylic acids, especially in aqueous solution, also react with sulfites, nitrites, thiosulfates (to give H2S and SO3), dithionites (SO2), to generate flammable and/or toxic gases and heat. Their reaction with carbonates and bicarbonates generates a harmless gas (carbon dioxide) but still heat. Like other organic compounds, carboxylic acids can be oxidized by strong oxidizing agents and reduced by strong reducing agents. These reactions generate heat. A wide variety of products is possible. Like other acids, carboxylic acids may initiate polymerization reactions; like other acids, they often catalyze (increase the rate of) chemical reactions.

Fire Hazard

Flash point data for 2,4-Dichlorobenzoic acid are not available; however, 2,4-Dichlorobenzoic acid is probably combustible.

Purification Methods

Crystallise the acid from aqueous EtOH (charcoal), then *benzene (charcoal). It can also be recrystallised from water. [Beilstein 9 IV 998.] It can be freed from isomeric acids (to <0.05%) via the (±)--methylbenzylamine salt as follows: dissolve the dichloro-acid (10g, 50.2mmol) in isopropanol (200mL), heat to 60o and add the (±)-benzylamine (5.49g, 45.3mmol), then stir it at 60o for 1hour. Cool the mixture to room temperature, filter the slurry, wash it with isopropanol (25mL) and dry it in vacuo at 40o overnight to give 79% of the salt with m 185.2o. Dissolve the salt (5g) in H2O (50mL) and MeOH (20mL), then heat to 60o and add concentrated HCl to pH <2.0. Cool the solution to room temperature add H2O (12mL), filter it, wash it with H2O (30mL) and dry it in vacuo at 40o overnight to give 94% of the acid with m 162.0o. [Ley & Yates Organic Process Research & Development 12 120 2008.]

Check Digit Verification of cas no

The CAS Registry Mumber 50-84-0 includes 5 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 2 digits, 5 and 0 respectively; the second part has 2 digits, 8 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 50-84:
(4*5)+(3*0)+(2*8)+(1*4)=40
40 % 10 = 0
So 50-84-0 is a valid CAS Registry Number.
InChI:InChI=1/C7H4Cl2O2/c8-4-1-2-5(7(10)11)6(9)3-4/h1-3H,(H,10,11)/p-1

50-84-0 Well-known Company Product Price

  • Brand
  • (Code)Product description
  • CAS number
  • Packaging
  • Price
  • Detail
  • Alfa Aesar

  • (A12372)  2,4-Dichlorobenzoic acid, 98%   

  • 50-84-0

  • 250g

  • 384.0CNY

  • Detail
  • Alfa Aesar

  • (A12372)  2,4-Dichlorobenzoic acid, 98%   

  • 50-84-0

  • 1000g

  • 1139.0CNY

  • Detail
  • Sigma-Aldrich

  • (36749)  2,4-Dichlorobenzoicacid  PESTANAL®, analytical standard

  • 50-84-0

  • 36749-1G

  • 329.94CNY

  • Detail

50-84-0Synthetic route

1,2-bis(2,4-dichlorobenzylidene)hydrazine
6319-33-1

1,2-bis(2,4-dichlorobenzylidene)hydrazine

2,4 dichlorobenzoic acid
50-84-0

2,4 dichlorobenzoic acid

Conditions
ConditionsYield
With poly(diselanediyl-1,2-phenylene); dihydrogen peroxide In tetrahydrofuran for 240h; Heating;100%
With [bis(acetoxy)iodo]benzene In tetrahydrofuran at 20℃; for 4h; Green chemistry;77%
2,4-Dichlor-1--benzol
1747-47-3

2,4-Dichlor-1--benzol

2,4 dichlorobenzoic acid
50-84-0

2,4 dichlorobenzoic acid

Conditions
ConditionsYield
With poly(diselanediyl-1,2-phenylene); dihydrogen peroxide In tetrahydrofuran for 48h; Heating;100%
2,4-dichlorobenzaldoxime
56843-28-8

2,4-dichlorobenzaldoxime

2,4 dichlorobenzoic acid
50-84-0

2,4 dichlorobenzoic acid

Conditions
ConditionsYield
With poly(diselanediyl-1,2-phenylene); dihydrogen peroxide In tetrahydrofuran for 145h; Heating;98%
2-bromo-4,6-dichlorobenzoic acid
650598-43-9

2-bromo-4,6-dichlorobenzoic acid

2,4 dichlorobenzoic acid
50-84-0

2,4 dichlorobenzoic acid

Conditions
ConditionsYield
With zinc In sodium hydroxide at 25℃; for 2h;98%
2,4-dichlorobenzaldeyhde
874-42-0

2,4-dichlorobenzaldeyhde

2,4 dichlorobenzoic acid
50-84-0

2,4 dichlorobenzoic acid

Conditions
ConditionsYield
With dihydrogen peroxide for 0.0361111h; Microwave irradiation;96%
With selenium(IV) oxide; dihydrogen peroxide In tetrahydrofuran for 18h; Heating;94%
With polysterene-bound phenylseleninic acid; dihydrogen peroxide In tetrahydrofuran for 12h; Heating;93%
2-oxo-2-(2,4-dichlorophenyl)ethanal
153147-35-4

2-oxo-2-(2,4-dichlorophenyl)ethanal

2,4 dichlorobenzoic acid
50-84-0

2,4 dichlorobenzoic acid

Conditions
ConditionsYield
With pyrrolidine; dihydrogen peroxide In toluene at 25℃; for 2h;96%
With iodine; dimethyl sulfoxide at 180℃; for 0.0833333h; Inert atmosphere; Microwave irradiation;92%
2,3-dichlorotoluene
32768-54-0

2,3-dichlorotoluene

2,4 dichlorobenzoic acid
50-84-0

2,4 dichlorobenzoic acid

Conditions
ConditionsYield
With hydrogen bromide In water95.1%
C7H4Cl2O2*C8H11N

C7H4Cl2O2*C8H11N

2,4 dichlorobenzoic acid
50-84-0

2,4 dichlorobenzoic acid

Conditions
ConditionsYield
With hydrogenchloride In methanol; water at 60℃;94%
2,4-dichloro-3-(triethylsilyl)benzoic acid
650598-47-3

2,4-dichloro-3-(triethylsilyl)benzoic acid

2,4 dichlorobenzoic acid
50-84-0

2,4 dichlorobenzoic acid

Conditions
ConditionsYield
With potassium hydroxide In methanol; water for 2h; Heating;92%
1-(2,4-dichlorophenyl)ethan-1-one
2234-16-4

1-(2,4-dichlorophenyl)ethan-1-one

2,4 dichlorobenzoic acid
50-84-0

2,4 dichlorobenzoic acid

Conditions
ConditionsYield
Stage #1: 1-(2,4-dichlorophenyl)ethan-1-one With tert.-butylhydroperoxide; sodium hydroxide; tungsten(VI) oxide In water at 80℃; for 8h;
Stage #2: With hydrogenchloride In water
92%
With hydroxylamine hydrochloride; iodine In dimethyl sulfoxide at 100℃; for 5h;87%
With Oxone; trifluoroacetic acid In 1,4-dioxane for 10h; Reflux; Green chemistry;80%
With copper(l) iodide; hydroxylamine hydrochloride; oxygen In dimethyl sulfoxide at 100℃; for 12h;60%
With dihydrogen peroxide In water at 22 - 25℃; for 11688h;
(2,4-dichlorophenyl)methanol
1777-82-8

(2,4-dichlorophenyl)methanol

2,4 dichlorobenzoic acid
50-84-0

2,4 dichlorobenzoic acid

Conditions
ConditionsYield
With Au NCs/TiO2; oxygen; sodium hydroxide In water at 120℃; under 7500.75 Torr; for 6h; Autoclave; Green chemistry;91.7%
With oxygen; sodium hydroxide In water at 90℃; for 16h; Catalytic behavior;87%
With potassium hydroxide In 1,3,5-trimethyl-benzene at 160℃; for 3h; Inert atmosphere;79%
2,4-dichlorobenzylnitrile
6574-98-7

2,4-dichlorobenzylnitrile

2,4 dichlorobenzoic acid
50-84-0

2,4 dichlorobenzoic acid

Conditions
ConditionsYield
With sulfuric acid at 125 - 130℃; for 2h;91%
With sulfuric acid
ethyl 2,4-dichlorobenzoate
56882-52-1

ethyl 2,4-dichlorobenzoate

2,4 dichlorobenzoic acid
50-84-0

2,4 dichlorobenzoic acid

Conditions
ConditionsYield
With aluminium(III) iodide In acetonitrile for 0.5h; Heating;90%
2,4-dichlorotoluene
95-73-8

2,4-dichlorotoluene

2,4 dichlorobenzoic acid
50-84-0

2,4 dichlorobenzoic acid

Conditions
ConditionsYield
Stage #1: 2,4-dichlorotoluene With tert.-butylhydroperoxide; sodium hydroxide; tungsten(VI) oxide In water at 80℃; for 10h;
Stage #2: With hydrogenchloride In water
83%
With sodium bromate; sulfuric acid; sodium bromide In water at 100℃; for 7h; Irradiation;82%
With manganese(IV) oxide; sulfuric acid at 80℃;
methanol
67-56-1

methanol

2,4-dichlorobenzaldeyhde
874-42-0

2,4-dichlorobenzaldeyhde

A

2,4 dichlorobenzoic acid
50-84-0

2,4 dichlorobenzoic acid

B

methyl 2,4-dichlorobenzoate
35112-28-8

methyl 2,4-dichlorobenzoate

Conditions
ConditionsYield
With dihydrogen peroxide; magnesium chloride at 65℃; for 40h;A n/a
B 82%
2,4-Dichlorobenzyl chloride
94-99-5

2,4-Dichlorobenzyl chloride

2,4 dichlorobenzoic acid
50-84-0

2,4 dichlorobenzoic acid

Conditions
ConditionsYield
With tert.-butylhydroperoxide at 100℃; for 5h;80%
(2,4-dichlorophenyl)methanol
1777-82-8

(2,4-dichlorophenyl)methanol

A

2,4 dichlorobenzoic acid
50-84-0

2,4 dichlorobenzoic acid

B

2,4-dichlorobenzaldeyhde
874-42-0

2,4-dichlorobenzaldeyhde

Conditions
ConditionsYield
With peracetic acid; C24H29INO5 In acetic acid at 30℃; for 48h;A 78%
B 13%
With CpMo(CO)3(CCPh); dihydrogen peroxide In water at 80℃; for 8h; chemoselective reaction;
With dihydrogen peroxide at 70℃; Catalytic behavior; Reagent/catalyst; Temperature;
With oxygen; potassium carbonate In water at 90℃; Catalytic behavior;A 52 %Chromat.
B 10 %Chromat.
2,4-dichlorobenzaldehyde, dimethylhydrazone
5051-49-0

2,4-dichlorobenzaldehyde, dimethylhydrazone

A

2,4 dichlorobenzoic acid
50-84-0

2,4 dichlorobenzoic acid

B

2,4-dichlorobenzylnitrile
6574-98-7

2,4-dichlorobenzylnitrile

Conditions
ConditionsYield
With dihydrogen peroxide; poly(bis-9,10-anthracenyl)diselenide In tert-butyl alcohol at 55℃; for 6h;A 7%
B 77%
C10H11Cl2O5P

C10H11Cl2O5P

2,4 dichlorobenzoic acid
50-84-0

2,4 dichlorobenzoic acid

Conditions
ConditionsYield
With tert.-butylhydroperoxide In toluene at 20℃; for 4h;75%
carbon dioxide
124-38-9

carbon dioxide

2,4-dichloro-1-iodo-benzene
29898-32-6

2,4-dichloro-1-iodo-benzene

2,4 dichlorobenzoic acid
50-84-0

2,4 dichlorobenzoic acid

Conditions
ConditionsYield
Stage #1: 2,4-dichloro-1-iodo-benzene With copper In tetrahydrofuran at 25℃; for 0.5h;
Stage #2: carbon dioxide In tetrahydrofuran for 24h;
74%
carbon monoxide
201230-82-2

carbon monoxide

2,4-dichloro-1-iodo-benzene
29898-32-6

2,4-dichloro-1-iodo-benzene

2,4 dichlorobenzoic acid
50-84-0

2,4 dichlorobenzoic acid

Conditions
ConditionsYield
With water; palladium diacetate; triethylamine; triphenylphosphine In 1,4-dioxane at 110℃; under 11251.1 Torr; for 2h; Flow reactor;69%
2,4-dichlorobenzaldehyde, dimethylhydrazone
5051-49-0

2,4-dichlorobenzaldehyde, dimethylhydrazone

A

2,4 dichlorobenzoic acid
50-84-0

2,4 dichlorobenzoic acid

B

2,4-dichlorobenzamide
2447-79-2

2,4-dichlorobenzamide

C

2,4-dichlorobenzylnitrile
6574-98-7

2,4-dichlorobenzylnitrile

Conditions
ConditionsYield
With dihydrogen peroxide; sodium carbonate; acetonitrile at 55℃; for 23h;A 19%
B 19%
C 57%
(E)-2,4-dichlorobenzaldehyde oxime
110853-58-2

(E)-2,4-dichlorobenzaldehyde oxime

acetonitrile
75-05-8

acetonitrile

A

2,4 dichlorobenzoic acid
50-84-0

2,4 dichlorobenzoic acid

B

2,4-dichlorobenzylnitrile
6574-98-7

2,4-dichlorobenzylnitrile

C

3-(2,4-dichlorophenyl)-5-methyl-1,2,4-oxadiazole
69792-78-5

3-(2,4-dichlorophenyl)-5-methyl-1,2,4-oxadiazole

Conditions
ConditionsYield
With ammonium cerium(IV) nitrate at 70℃; for 1h; Yields of byproduct given;A 11%
B n/a
C 42%
2,4-dichlorobenzoyl cyanide
35022-43-6

2,4-dichlorobenzoyl cyanide

2,4 dichlorobenzoic acid
50-84-0

2,4 dichlorobenzoic acid

Conditions
ConditionsYield
With sulfuric acid; water at 103℃; for 0.5h;40%
3,5-dichloro-1-nitrobenzene
618-62-2

3,5-dichloro-1-nitrobenzene

potassium cyanide
151-50-8

potassium cyanide

2,4 dichlorobenzoic acid
50-84-0

2,4 dichlorobenzoic acid

Conditions
ConditionsYield
With ethanol
4-amino-2-aminobenzoic acid
611-03-0

4-amino-2-aminobenzoic acid

2,4 dichlorobenzoic acid
50-84-0

2,4 dichlorobenzoic acid

Conditions
ConditionsYield
With copper; copper dichloride; sodium nitrite
2,4,β-trichloro-cinnamic acid

2,4,β-trichloro-cinnamic acid

2,4 dichlorobenzoic acid
50-84-0

2,4 dichlorobenzoic acid

Conditions
ConditionsYield
With potassium permanganate; sodium carbonate
2,4-dichlorobenzaldeyhde
874-42-0

2,4-dichlorobenzaldeyhde

A

(2,4-dichlorophenyl)methanol
1777-82-8

(2,4-dichlorophenyl)methanol

B

2,4 dichlorobenzoic acid
50-84-0

2,4 dichlorobenzoic acid

Conditions
ConditionsYield
With methanol; sodium methylate at 183℃;
With potassium hydroxide
With tetrabutylammomium bromide; sodium hydroxide In toluene at 35℃; for 1.08333h; Concentration;
2,4-dichlorobenzotrichloride
13014-18-1

2,4-dichlorobenzotrichloride

2,4 dichlorobenzoic acid
50-84-0

2,4 dichlorobenzoic acid

Conditions
ConditionsYield
beim Verseifen;
2-Amino-4-chlorobenzoic acid
89-77-0

2-Amino-4-chlorobenzoic acid

2,4 dichlorobenzoic acid
50-84-0

2,4 dichlorobenzoic acid

Conditions
ConditionsYield
Diazotization.Einw. von CuCl und HCl auf das Diazotierungsprodukt;
(-)-trans-acetic acid 3-(3-acetyl-2-hydroxy-4,6-dimethoxyphenyl)-1-methyl-pyrrolidin-2-ylmethyl ester

(-)-trans-acetic acid 3-(3-acetyl-2-hydroxy-4,6-dimethoxyphenyl)-1-methyl-pyrrolidin-2-ylmethyl ester

2,4 dichlorobenzoic acid
50-84-0

2,4 dichlorobenzoic acid

(+)-trans-2,4-dichloro-benzoic acid 2-(2-acetoxymethyl-1-methylpyrrolidin-3-yl)-6-acetyl-3,5-dimethoxy-phenyl ester

(+)-trans-2,4-dichloro-benzoic acid 2-(2-acetoxymethyl-1-methylpyrrolidin-3-yl)-6-acetyl-3,5-dimethoxy-phenyl ester

Conditions
ConditionsYield
With dmap; dicyclohexyl-carbodiimide In dichloromethane at 20℃; for 12h;100%
2,4 dichlorobenzoic acid
50-84-0

2,4 dichlorobenzoic acid

(-)-trans-acetic acid 3-(3-acetyl-2-hydroxy-4,6-dimethoxy-phenyl)-1-methyl-pyrrolidin-2-yl methyl ester

(-)-trans-acetic acid 3-(3-acetyl-2-hydroxy-4,6-dimethoxy-phenyl)-1-methyl-pyrrolidin-2-yl methyl ester

(+)-trans-2,4-dichloro-benzoic acid 2-(2-acetoxymethyl-1-methylpyrrolidin-3-yl)-6-acetyl-3,5-dimethoxy-phenyl ester

(+)-trans-2,4-dichloro-benzoic acid 2-(2-acetoxymethyl-1-methylpyrrolidin-3-yl)-6-acetyl-3,5-dimethoxy-phenyl ester

Conditions
ConditionsYield
With dmap; dicyclohexyl-carbodiimide In dichloromethane at 20℃; for 12h;100%
2,4 dichlorobenzoic acid
50-84-0

2,4 dichlorobenzoic acid

4-(2-methylthiazol-4-yl)benzenamine
25021-49-2

4-(2-methylthiazol-4-yl)benzenamine

2,4-dichloro-N-(4-(2-methylthiazol-4-yl)phenyl)benzamide
713098-89-6

2,4-dichloro-N-(4-(2-methylthiazol-4-yl)phenyl)benzamide

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine; HATU In N,N-dimethyl-formamide at 20℃; for 4h;100%
2,4 dichlorobenzoic acid
50-84-0

2,4 dichlorobenzoic acid

5-bromo-2,4-dichloro benzoic acid
791137-20-7

5-bromo-2,4-dichloro benzoic acid

Conditions
ConditionsYield
With chlorosulfonic acid; bromine; sulfur at 70℃; for 16h;99.08%
With chlorosulfonic acid; bromine; sulfur at 60 - 70℃; for 24h;95%
With chlorosulfonic acid; bromine; sulfur at 70℃; Inert atmosphere;94%
With bromine; sulfur In chlorosulfonic acid at 70℃; Inert atmosphere;93%
With chlorosulphuric acid; bromine; sulfur at 60 - 70℃;
2,4 dichlorobenzoic acid
50-84-0

2,4 dichlorobenzoic acid

p-toluidine
106-49-0

p-toluidine

2-[(4-methylphenyl)amino]-5-chlorobenzoic acid
32305-30-9

2-[(4-methylphenyl)amino]-5-chlorobenzoic acid

Conditions
ConditionsYield
With potassium carbonate; copper In N,N-dimethyl-formamide at 140 - 150℃;99%
With copper(I) sulfate; potassium carbonate; copper(II) sulfate In water for 0.116667h; Ullmann condensation; microwave irradiation;95%
With potassium carbonate; copper(II) sulfate for 0.0333333h; Ullmann condensation; microwave irradiation;95%
3-Aminomethylpyridine
3731-52-0

3-Aminomethylpyridine

2,4 dichlorobenzoic acid
50-84-0

2,4 dichlorobenzoic acid

potassium carbonate
584-08-7

potassium carbonate

4-Chloro-2-(pyridin-3-ylmethylamino)benzoic acid

4-Chloro-2-(pyridin-3-ylmethylamino)benzoic acid

Conditions
ConditionsYield
copper(I) bromide In N,N-dimethyl-formamide99%
2,4 dichlorobenzoic acid
50-84-0

2,4 dichlorobenzoic acid

benzoic acid
65-85-0

benzoic acid

Conditions
ConditionsYield
With ammonium formate In water; isopropyl alcohol at 20℃; for 3h;99%
With borane-ammonia complex In water; isopropyl alcohol at 50℃; for 5h; Sealed tube;97%
Stage #1: 2,4 dichlorobenzoic acid With 1,2-disodiotetraphenylethane In tetrahydrofuran at 0 - 20℃; for 12h; Inert atmosphere;
Stage #2: With hydrogenchloride In water at 20℃;
> 95 %Spectr.
2,4 dichlorobenzoic acid
50-84-0

2,4 dichlorobenzoic acid

4,4,5,5-tetramethyl-[1,3,2]-dioxaboralane
25015-63-8

4,4,5,5-tetramethyl-[1,3,2]-dioxaboralane

2-((2,4-dichlorobenzyl)oxy)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

2-((2,4-dichlorobenzyl)oxy)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

Conditions
ConditionsYield
In neat (no solvent) at 30℃; Inert atmosphere; Schlenk technique; Glovebox; chemoselective reaction;99%
2-amino-3-methoxybenzoic acid
3177-80-8

2-amino-3-methoxybenzoic acid

2,4 dichlorobenzoic acid
50-84-0

2,4 dichlorobenzoic acid

2-((2-carboxy-5-chlorophenyl)amino)-3-methoxybenzoic acid
1300731-90-1

2-((2-carboxy-5-chlorophenyl)amino)-3-methoxybenzoic acid

Conditions
ConditionsYield
With copper; potassium carbonate In N,N-dimethyl-formamide at 130℃; Ullmann-Goldberg Substitution;98.9%
Stage #1: 2-amino-3-methoxybenzoic acid; 2,4 dichlorobenzoic acid With copper; potassium carbonate In N,N-dimethyl-formamide at 130℃;
Stage #2: With hydrogenchloride In water; N,N-dimethyl-formamide pH=Ca. 3;
98.9%
With copper; potassium carbonate In N,N-dimethyl-formamide at 130℃;98.9%
With copper; potassium carbonate In N,N-dimethyl-formamide at 130℃; Ullmann Condensation;98.9%
2,4 dichlorobenzoic acid
50-84-0

2,4 dichlorobenzoic acid

2,4-dichloro-5-nitrobenzoic acid
19861-62-2

2,4-dichloro-5-nitrobenzoic acid

Conditions
ConditionsYield
With sulfuric acid; nitric acid at 0 - 20℃;98%
With sulfuric acid; nitric acid at 0 - 20℃; for 2h;91%
With sulfuric acid; nitric acid at 0 - 20℃; for 2h;91%
With sulfuric acid; nitric acid at 10℃;
2,4 dichlorobenzoic acid
50-84-0

2,4 dichlorobenzoic acid

o-toluidine
95-53-4

o-toluidine

4-chloro-2-o-toluidino-benzoic acid
32305-28-5

4-chloro-2-o-toluidino-benzoic acid

Conditions
ConditionsYield
With potassium carbonate; copper In N,N-dimethyl-formamide at 140 - 150℃;98%
With pentan-1-ol; copper; potassium carbonate
With copper; potassium carbonate In pentan-1-ol
With copper; potassium carbonate In N,N-dimethyl-formamide Goldberg Reaction; Heating;
methanol
67-56-1

methanol

2,4 dichlorobenzoic acid
50-84-0

2,4 dichlorobenzoic acid

methyl 2,4-dichlorobenzoate
35112-28-8

methyl 2,4-dichlorobenzoate

Conditions
ConditionsYield
With sulfuric acid Reflux;98%
With potassium carbonate In acetonitrile at 50℃; Sealed tube; Inert atmosphere; Sonication;95%
Acidic conditions;88%
2,4 dichlorobenzoic acid
50-84-0

2,4 dichlorobenzoic acid

1-(2,4-dichloro-6-hydroxyphenyl)ethanone
57051-50-0

1-(2,4-dichloro-6-hydroxyphenyl)ethanone

4',6-dichloro-2'-(2,4-dichlorobenzoyloxy)acetophenone
1023278-90-1

4',6-dichloro-2'-(2,4-dichlorobenzoyloxy)acetophenone

Conditions
ConditionsYield
With 4-pyrrolidin-1-ylpyridine; dicyclohexyl-carbodiimide In dichloromethane at 20℃; for 24h;98%
2,4 dichlorobenzoic acid
50-84-0

2,4 dichlorobenzoic acid

(2,4-dichlorophenyl)methanol
1777-82-8

(2,4-dichlorophenyl)methanol

Conditions
ConditionsYield
With sodium bis(2-methoxyethoxy)aluminium dihydride In diethyl ether at 20℃; for 1h; Temperature; Reagent/catalyst; Solvent;97%
With lithium aluminium tetrahydride In tetrahydrofuran Heating;
With sodium hydroxide; polymethylhydrosiloxane; tetrabutyl ammonium fluoride 1.) THF, room t., 2.) THF; Yield given. Multistep reaction;
Multi-step reaction with 2 steps
1: neat (no solvent) / 30 °C / Inert atmosphere; Schlenk technique; Glovebox
2: silica gel / methanol / 3 h / 60 °C / Inert atmosphere
View Scheme
cupric chloride

cupric chloride

2,4 dichlorobenzoic acid
50-84-0

2,4 dichlorobenzoic acid

ethanolamine
141-43-5

ethanolamine

4-chloro-2-[(2-hydroxyethyl)amino]benzoic acid
192719-21-4

4-chloro-2-[(2-hydroxyethyl)amino]benzoic acid

Conditions
ConditionsYield
97%
2,4 dichlorobenzoic acid
50-84-0

2,4 dichlorobenzoic acid

2-bromothiophene-5-sulfonyl azide
1152981-12-8

2-bromothiophene-5-sulfonyl azide

2,4-dichloro-N-[(5-bromo-2-thienyl)sulfonyl]benzenecarboxamide
519055-62-0

2,4-dichloro-N-[(5-bromo-2-thienyl)sulfonyl]benzenecarboxamide

Conditions
ConditionsYield
With 2-chloro-4,4,5,5-tetramethyl-1,3,2-dioxaphospholane; triethylamine In chlorobenzene at 20 - 130℃; for 12h; chemoselective reaction;97%
With dicobalt octacarbonyl; tert-butylisonitrile In acetonitrile at 80℃; for 4h;76%
With dicobalt octacarbonyl; tert-butylisonitrile In acetonitrile at 80℃; for 4h;76%
NH-pyrazole
288-13-1

NH-pyrazole

2,4 dichlorobenzoic acid
50-84-0

2,4 dichlorobenzoic acid

4-chloro-2-(1H-pyrazol-1-yl)benzoic acid

4-chloro-2-(1H-pyrazol-1-yl)benzoic acid

Conditions
ConditionsYield
With D-galacturonic acid; potassium carbonate; copper(I) bromide In water; dimethyl sulfoxide at 80 - 100℃; Inert atmosphere; Green chemistry;97%
2,4 dichlorobenzoic acid
50-84-0

2,4 dichlorobenzoic acid

4-chloro-aniline
106-47-8

4-chloro-aniline

4-chloro-2-(4-chloro-anilino)-benzoic acid
90656-45-4

4-chloro-2-(4-chloro-anilino)-benzoic acid

Conditions
ConditionsYield
With potassium carbonate; copper In N,N-dimethyl-formamide at 140 - 150℃;96%
With copper; potassium carbonate; butan-1-ol
With copper; potassium carbonate In i-Amyl alcohol for 3h; Heating;
With copper; potassium carbonate; butan-1-ol
With copper; potassium carbonate; butan-1-ol
2,4 dichlorobenzoic acid
50-84-0

2,4 dichlorobenzoic acid

N-benzyloxyamine
622-33-3

N-benzyloxyamine

N-benzyloxy-2,4-dichlorobenzamide

N-benzyloxy-2,4-dichlorobenzamide

Conditions
ConditionsYield
With phosphoric acid di-Et ester 2-phenylbenzimidazol-1-yl ester In N,N-dimethyl-formamide at 20℃; for 0.583333h;96%
2,4 dichlorobenzoic acid
50-84-0

2,4 dichlorobenzoic acid

2,4-dichlorobenzoyl chloride
89-75-8

2,4-dichlorobenzoyl chloride

Conditions
ConditionsYield
With pyridine; oxalyl dichloride In toluene at 60℃;95.5%
With thionyl chloride at 100 - 135℃;
With phosphorus pentachloride
1,3-bis((E)-2-(pyridin-4-yl)vinyl)benzene
21915-02-6

1,3-bis((E)-2-(pyridin-4-yl)vinyl)benzene

cadmium sulfate octahydrate

cadmium sulfate octahydrate

2,4 dichlorobenzoic acid
50-84-0

2,4 dichlorobenzoic acid

2Cd(2+)*4C7H3Cl2O2(1-)*2C20H16N2

2Cd(2+)*4C7H3Cl2O2(1-)*2C20H16N2

Conditions
ConditionsYield
With methanol; nitric acid In water; N,N-dimethyl-formamide at 140℃; for 5h; Sealed tube;95.3%
2,4 dichlorobenzoic acid
50-84-0

2,4 dichlorobenzoic acid

4-chlorosalicylic acid
5106-98-9

4-chlorosalicylic acid

Conditions
ConditionsYield
With pyridine; water; potassium carbonate; copper for 0.25h; sonication;95%
With pyridine; copper; potassium carbonate In water for 2h; Heating;88%
With copper(l) iodide; copper; potassium carbonate at 180℃; under 7355.08 Torr;
With barium dihydroxide; water; copper at 160 - 170℃;
Stage #1: 2,4 dichlorobenzoic acid With sodium carbonate In water at 50 - 75℃;
Stage #2: trans-N,N'-dimethyl-1,2-cyclohexyldiamine; copper(II) sulfate at 100℃; for 4h;
Stage #3: With hydrogenchloride In water at 20℃; Product distribution / selectivity;
2,4 dichlorobenzoic acid
50-84-0

2,4 dichlorobenzoic acid

2-methoxy-phenylamine
90-04-0

2-methoxy-phenylamine

N-(2-Methoxyphenyl)-4-chloroanthranilic acid
32305-23-0

N-(2-Methoxyphenyl)-4-chloroanthranilic acid

Conditions
ConditionsYield
With potassium carbonate; copper In N,N-dimethyl-formamide at 140 - 150℃; for 12h;95%
With copper(I) sulfate; potassium carbonate; copper(II) sulfate In water for 0.133333h; Ullmann condensation; microwave irradiation;94%
With potassium carbonate; copper(II) sulfate for 0.0666667h; Ullmann condensation; microwave irradiation;94%

50-84-0Relevant articles and documents

Purification of 2,4 dichlorobenzoic acid

Ley, Christopher P.,Yates, Matthew H.

, p. 120 - 124 (2008)

A practical and efficient method to purify 2,4-dichlorobenzoic acid is described. The formation of an α-methylbenzylamine salt reduces the levels of positional isomer impurities to 0.05%. Although this purification method is not universal for all substituted benzoic acids, it was shown to be applicable to several other benzoic acids.

Sequential Connection of Mutually Exclusive Catalytic Reactions by a Method Controlling the Presence of an MOF Catalyst: One-Pot Oxidation of Alcohols to Carboxylic Acids

Kim, Seongwoo,Lee, Ha-Eun,Suh, Jong-Min,Lim, Mi Hee,Kim, Min

supporting information, p. 17573 - 17582 (2020/12/22)

A functionalized metal-organic framework (MOF) catalyst applied to the sequential one-pot oxidation of alcohols to carboxylic acids controls the presence of a heterogeneous catalyst. The conversion of alcohols to aldehydes was acquired through aerobic oxidation using a well-known amino-oxy radical-functionalized MOF. In the same flask, a simple filtration of the radical MOF with mild heating of the solution completely altered the reaction media, providing radical scavenger-free conditions suitable for the autoxidation of the aldehydes formed in the first step to carboxylic acids. The mutually exclusive radical-catalyzed aerobic oxidation (the first step with MOF) and radical-inhibited autoxidation (the second step without MOF) are sequentially achieved in a one-pot manner. Overall, we demonstrate a powerful and efficient method for the sequential oxidation of alcohols to carboxylic acids by employing a readily functionalizable heterogeneous MOF. In addition, our MOF in-and-out method can be utilized in an environmentally friendly way for the oxidation of alcohols to carboxylic acids of industrial and economic value with broad functional group tolerance, including 2,5-furandicarboxylic acid and 1,4-benzenedicarboxylic acid, with good yield and reusability. Furthermore, MOF-TEMPO, as an antioxidative stabilizer, prevents the undesired oxidation of aldehydes, and the perfect "recoverability"of such a reactive MOF requires a re-evaluation of the advantages of MOFs from heterogeneity in catalytic and related applications.

Method for catalytic oxidation of toluene and derivatives thereof by metalloporphyrin

-

Paragraph 0079-0080, (2020/09/30)

The invention relates to a method for catalytic oxidation of toluene and derivatives thereof by metalloporphyrin. The method comprises the following steps: dispersing metalloporphyrin and N-hydroxyphthalimide (NHPI) into methylbenzene and derivatives thereof, sealing the reaction system, heating to 70-130 DEG C while stirring, introducing oxygen to 0.2-2.0 MPa, keeping the set temperature and oxygen pressure, carrying out reactions for 8 hours under stirring, and carrying out after-treatment on the reaction solution to obtain the product aromatic acid. The method has the advantages of no solvent, no additive, mild conditions, higher selectivity to aromatic acids and good tolerance to substrates. The method not only can effectively oxidize hydrocarbon containing primary benzyl C-H bonds, but also can provide important reference for constructing a more effective C-H bond oxidation system, and is a novel efficient and feasible selective catalytic oxidation method for methylbenzene and derivatives thereof.

Post a RFQ

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

1

What can I do for you?
Get Best Price

Get Best Price for 50-84-0