500360-86-1

Basic information

• Product Name: 3,9-Diazaspiro[5.5]undecan-2-one, 9-(phenylmethyl)-
• Synonyms: 3,9-Diazaspiro[5.5]undecan-2-one, 9-(phenylmethyl)-;9-benzyl-3,9-diazaspiro[5.5]undecan-2-on
• CAS NO: 500360-86-1
• Molecular Formula: C16H22N2O
• Molecular Weight: 258.35868
• Mol File: 500360-86-1.mol

Chemical Properties

• Boiling Point: 443.6°C at 760 mmHg
• Flash Point: 222.1°C
• Appearance: /
• Density: 1.13g/cm³
• Vapor Pressure: 4.59E-08mmHg at 25°C
• Refractive Index: 1.586
• CAS DataBase Reference: 3,9-Diazaspiro[5.5]undecan-2-one, 9-(phenylmethyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 3,9-Diazaspiro[5.5]undecan-2-one, 9-(phenylmethyl)-(500360-86-1)
• EPA Substance Registry System: 3,9-Diazaspiro[5.5]undecan-2-one, 9-(phenylmethyl)-(500360-86-1)

Safety Data

• Hazardous Substances Data: 500360-86-1(Hazardous Substances Data)

Usage

InChI:InChI=1/C16H22N2O/c19-15-12-16(6-9-17-15)7-10-18(11-8-16)13-14-4-2-1-3-5-14/h1-5H,6-13H2,(H,17,19)

Relevant articles and documents

Practical and divergent synthesis of 1- and 5-substituted 3,9-diazaspiro[5.5]undecanes and undecan-2-ones

A divergent synthesis of 1- and 5-substituted 3,9-diazaspiro[5.5]undecanes and undecan-2-ones is described, in which the key step is an efficient Michael addition of a lithium enolate to a tetrasubstituted olefin acceptor. A variety of substituents (butyl, phenyl, and propoxyl) were introduced at C-1(5) in this manner. In addition, an asymmetric synthesis of one member of this series was achieved using an Evans oxazolidinone chiral auxiliary reagent.

SUBSTITUTED DIAZA-SPIRO-[5.5]-UNDECANE DERIVATIVES AND THEIR USE AS NEUROKININ ANTAGONISTS

This invention concerns substituted diaza-spiro-[5.5]-undecane derivatives having neurokinin antagonistic activity, in particular NK1 antagonistic activity, a combined NK1/NK2 antagonistic activity, a combined NK1/su