5004-48-8

Basic information

• Product Name: 4-METHYLPHTHALAZIN-1(2H)-ONE
• Synonyms: 4-METHYLPHTHALAZIN-1(2H)-ONE;4-METHYL-2H-PHTHALAZIN-1-ONE;AURORA KA-5078;1-Methylphthalazine-4(3H)-one;ICX-56274004;4-methyl-1(2H)-phthalazinone(SALTDATA: FREE);4-Methyl-1-phthalazinol;4-Methyl-1-phthalazinone
• CAS NO: 5004-48-8
• Molecular Formula: C₉H₈N₂O
• Molecular Weight: 160.17
• Product Categories: Miscellaneous Reagents
• Mol File: 5004-48-8.mol
• Article Data: 2

Chemical Properties

• Melting Point: 223-224°C
• Appearance: Colourless Cyrstalline Solid
• Density: 1.27 g/cm³
• Refractive Index: 1.644
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 12.32±0.40(Predicted)
• CAS DataBase Reference: 4-METHYLPHTHALAZIN-1(2H)-ONE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-METHYLPHTHALAZIN-1(2H)-ONE(5004-48-8)
• EPA Substance Registry System: 4-METHYLPHTHALAZIN-1(2H)-ONE(5004-48-8)

Safety Data

• Hazardous Substances Data: 5004-48-8(Hazardous Substances Data)

Usage

Uses

Hydroxy-4-methylphthalazine (cas# 5004-48-8) is a compound useful in organic synthesis.

InChI:InChI=1/C9H8N2O/c1-6-7-4-2-3-5-8(7)9(12)11-10-6/h2-5H,1H3,(H,11,12)

Upstream product

• 33930-79-9 2-methyl-4-nitroisoquinolin-1(2H)-one 
• 84257-71-6 1-(ethoxycarbonylmethylthio)-4-methylphthalazine 

Downstream Products

• 54145-23-2 4-methyl-1(2H)-phthalazinethione 
• 84257-65-8 4-methyl-2-(p-methylbenzyl)-1-phthalazinone 
• 84257-67-0 4-methyl-2-(benzenesulfonyl)-1-phthalazinone 
• 84257-68-1 4-methyl-2-(p-toluenesulfonyl)-1-phthalazinone 
• 84257-66-9 4-methyl-2-(p-nitrobenzyl)-1-phthalazinone 
• 19064-68-7 1-chloro-4-methylphthalazine 
• 763114-26-7 2-fluoro-5-[(4’-oxo-3’H-phthalazin-1’-yl)methyl]benzoic acid 
• 763113-22-0 olaparib 
• 52952-31-5 tetrabenzoporphyrin 
• 84257-74-9 3-(p-nitrophenyl)-6-methyl-s-triazolo<3,4-a>phthalazine 
• 84257-73-8 N-(4-methylphthalazin-1-yl)-p-nitrobenzaldehyde hydrazone 
• 84257-70-5 1-(p-nitrobenzylthio)-4-methylphthalazine 

Relevant articles and documents

Cyclotransformation in the series of fused 5-nitropyridin-2(1H)-ones

Reactions with excess hydrazine hydrate of 5-nitropyridin-2(1H)-ones fused with benzene, pyridine, and 1,2,3-triazole rings led to a cyclotransformation of the 5-nitro-2-oxopyridine fragment into the 6-methyl-3-oxopyridazine structure. This cyclotransformation is of general character; a probable mechanism of the process is suggested. Details of the assumed mechanism were experimentally confirmed on model compounds.