501446-78-2

Basic information

• Product Name: [1,4'-Bipiperidine]-1'-carboxylic acid, 4'-methyl-4-[(phenylmethyl)amino]-, 1,1-dimethylethyl ester
• CAS NO: 501446-78-2
• Molecular Formula: C23H37N3O2
• Molecular Weight: 387.566
• Mol File: 501446-78-2.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: [1,4'-Bipiperidine]-1'-carboxylic acid, 4'-methyl-4-[(phenylmethyl)amino]-, 1,1-dimethylethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: [1,4'-Bipiperidine]-1'-carboxylic acid, 4'-methyl-4-[(phenylmethyl)amino]-, 1,1-dimethylethyl ester(501446-78-2)
• EPA Substance Registry System: [1,4'-Bipiperidine]-1'-carboxylic acid, 4'-methyl-4-[(phenylmethyl)amino]-, 1,1-dimethylethyl ester(501446-78-2)

Safety Data

• Hazardous Substances Data: 501446-78-2(Hazardous Substances Data)

Upstream product

• 100-46-9 benzylamine 
• 438208-23-2 4'-methyl-4-oxo-[1,4']bipiperidinyl-1'-carboxylic acid tert-butyl ester 

Downstream Products

• 501446-79-3 C₂₈H₄₀N₄O₂ 
• 902473-16-9 tert-butyl 4-{benzyl[(3,3-difluorocyclobutyl)carbonyl]amino}-4'-methyl-1,4'-bipiperidine-1'-carboxylate 
• 851705-21-0 C₂₉H₄₂N₄O₃ 

Relevant articles and documents

CHEMICAL COMPOUNDS

The present invention provides compounds of formula (I) wherein R1, R2, R3, R4, R5, m and n are as defined hereinabove. The compounds of the present invention are modulators, especially antagonists, of the activity of chemokine CCR5 receptors. Modulators of the CCR5 receptor may be useful in the treatment of various inflammatory diseases and conditions, and in the treatment of infection by HIV and genetically related retroviruses.

Piperidine derivatives useful as CCR5 antagonists

The present invention provides a compound of the formula or a pharmaceutically acceptable salt or solvate thereof, wherein R1, R2, R3, R9, R10, A and B are as defined in the specification. The present invention also provides pharmaceutical compositions containing the compound of this invention, and methods of treatment using the compound of this invention. The invention also relates to the use of a combination of a compound of this invention and one or more antiviral or other agents useful in the treatment of Human Immunodeficiency Virus (HIV). The invention further relates to the use of a compound of this invention, alone or in combination with another agent, in the treatment of solid organ transplant rejection, graft v. host disease, arthritis, rheumatoid arthritis, inflammatory bowel disease, atopic dermatitis, psoriasis, asthma, allergies or multiple sclerosis.