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Cas Database

5018-84-8

5018-84-8

Identification

  • Product Name:9,10-Anthracenedione, 1-hydroxy-6,8-dimethoxy-3-methyl-

  • CAS Number: 5018-84-8

  • EINECS:

  • Molecular Weight:298.295

  • Molecular Formula: C17H14O5

  • HS Code:

  • Mol File:5018-84-8.mol

Synonyms:

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Safety information and MSDS view more

  • Signal Word:no data available

  • Hazard Statement:no data available

  • First-aid measures: General adviceConsult a physician. Show this safety data sheet to the doctor in attendance.If inhaled If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician. In case of skin contact Wash off with soap and plenty of water. Consult a physician. In case of eye contact Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician. If swallowed Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.

  • Fire-fighting measures: Suitable extinguishing media Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide. Wear self-contained breathing apparatus for firefighting if necessary.

  • Accidental release measures: Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. For personal protection see section 8. Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided. Pick up and arrange disposal. Sweep up and shovel. Keep in suitable, closed containers for disposal.

  • Handling and storage: Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Avoid exposure - obtain special instructions before use.Provide appropriate exhaust ventilation at places where dust is formed. For precautions see section 2.2. Store in cool place. Keep container tightly closed in a dry and well-ventilated place.

  • Exposure controls/personal protection:Occupational Exposure limit valuesBiological limit values Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday. Eye/face protection Safety glasses with side-shields conforming to EN166. Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU). Skin protection Wear impervious clothing. The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace. Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique(without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it. Respiratory protection Wear dust mask when handling large quantities. Thermal hazards

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Relevant articles and documentsAll total 2 Articles be found

ISOLATION, CHARACTERIZATION AND SYNTHESIS OF THREE NEW ANTHRAQUINONE GLYCOSIDES FROM CASSIA GRANDIS

Singh, M.,Siddiqui, I. R.,Gupta, D.,Singh, J.

, p. 469 - 475 (2007/10/02)

From the seeds of Cassia grandis three glycosides, namely 2-O-β-D-glucopyranosyl-1,2,4,8-tetrahydroxy-6-methoxy-3-methylanthraquinone, 3-O-β-D-glucopyranosyl-3-hydroxy-6,8-dimethoxy-2-methylanthraquinone and 3-O-β-D-glucopyranosyl-1,3-dihydroxy-6,7,8-trimethoxy-2-methylanthraquinone have been isolated.The structures were determined by spectroscopic methods and confirmed by synthesis.

REACTIONS OF KETENE ACETALS-14; THE USE OF SIMPLE MIXED VINYLKETENE ACETALS IN THE ANNULATION OF QUINONES

Savard, Jacques,Brassard, Paul

, p. 3455 - 3464 (2007/10/02)

α,β- and β,γ-unsaturated esters can be converted by strong base and chlorotrimethylsilane to the corresponding mixed vinylketene acetals which are shown to be particularly useful and generally applicable reagents for the regiospecific annulation of halogenoquinones.The reaction proceeds readily with a variety of substrates including benzoquinones.

Process route upstream and downstream products

Process route

3-chloro-5-hydroxy-7-methoxy-1,4-naphthoquinone
65120-69-6

3-chloro-5-hydroxy-7-methoxy-1,4-naphthoquinone

(E)-((1-methoxy-3-methylbuta-1,3-dien-1-yl)oxy)trimethylsilane
76927-59-8

(E)-((1-methoxy-3-methylbuta-1,3-dien-1-yl)oxy)trimethylsilane

physcion
521-61-9

physcion

emodin-6,8-di-O-methyl ether
5018-84-8

emodin-6,8-di-O-methyl ether

methyl 3-methyl-4-<3-chloro-5-hydroxy-7-methoxynaphthoquinonyl-2>-2-butenoate
95393-78-5

methyl 3-methyl-4-<3-chloro-5-hydroxy-7-methoxynaphthoquinonyl-2>-2-butenoate

Conditions
Conditions Yield
In tetrahydrofuran; Ambient temperature;
10%
8%
68%
3,5-dimethoxyphthalic anhydride
4670-17-1

3,5-dimethoxyphthalic anhydride

ortho-cresol
95-48-7,77504-84-8

ortho-cresol

emodin-6,8-di-O-methyl ether
5018-84-8

emodin-6,8-di-O-methyl ether

3,5-dimethoxy-2-(4-hydroxy-3-methylbenzoyl)benzoic acid
144828-20-6

3,5-dimethoxy-2-(4-hydroxy-3-methylbenzoyl)benzoic acid

Conditions
Conditions Yield
With aluminium trichloride; at 40 - 160 ℃; for 1h; Title compound not separated from byproducts;
emodin-6,8-di-O-methyl ether
5018-84-8

emodin-6,8-di-O-methyl ether

1,6,8-trihydroxy-3-methyl-9,10-anthraquinone
518-82-1

1,6,8-trihydroxy-3-methyl-9,10-anthraquinone

Conditions
Conditions Yield
With hydrogen bromide; In acetic acid; Heating;
With hydrogen bromide; In acetic acid; for 24h; Heating;
6 mg
Multi-step reaction with 2 steps
1: AlCl3
2: HBr
With aluminium trichloride; hydrogen bromide;
emodin-6,8-di-O-methyl ether
5018-84-8

emodin-6,8-di-O-methyl ether

physcion
521-61-9

physcion

Conditions
Conditions Yield
With aluminium trichloride;
With hydrogen bromide; In acetic acid;
With sulfuric acid; at 100 ℃; for 1.5h;
5 mg
emodin-6,8-di-O-methyl ether
5018-84-8

emodin-6,8-di-O-methyl ether

3-benzyl-5-fluoro-1-((1,6,8-trimethoxy-3-methyl-9,10-dioxo-9,10-dihydroanthracen-2-yl)methyl)pyrimidine-2,4(1H,3H)-dione
1354568-76-5

3-benzyl-5-fluoro-1-((1,6,8-trimethoxy-3-methyl-9,10-dioxo-9,10-dihydroanthracen-2-yl)methyl)pyrimidine-2,4(1H,3H)-dione

Conditions
Conditions Yield
Multi-step reaction with 5 steps
1.1: sodium dithionite; sodium hydroxide / methanol / 0.5 h / 0 °C
2.1: potassium carbonate / acetone / 16 h / Reflux
3.1: thionyl chloride / dichloromethane / 0.5 h / 20 °C
4.1: potassium carbonate / dimethyl sulfoxide / 0.5 h / 80 °C
4.2: 5 h / 20 °C
5.1: potassium carbonate / dimethyl sulfoxide / 0.5 h / 80 °C
5.2: 20 °C
With thionyl chloride; sodium dithionite; potassium carbonate; sodium hydroxide; In methanol; dichloromethane; dimethyl sulfoxide; acetone; 1.1: Marschalk type reaction;
emodin-6,8-di-O-methyl ether
5018-84-8

emodin-6,8-di-O-methyl ether

5-fluoro-3-phenethyl-1-((1,6,8-trimethoxy-3-methyl-9,10-dioxo-9,10-dihydroanthracen-2-yl)methyl)pyrimidine-2,4(1H,3H)-dione
1354568-77-6

5-fluoro-3-phenethyl-1-((1,6,8-trimethoxy-3-methyl-9,10-dioxo-9,10-dihydroanthracen-2-yl)methyl)pyrimidine-2,4(1H,3H)-dione

Conditions
Conditions Yield
Multi-step reaction with 5 steps
1.1: sodium dithionite; sodium hydroxide / methanol / 0.5 h / 0 °C
2.1: potassium carbonate / acetone / 16 h / Reflux
3.1: thionyl chloride / dichloromethane / 0.5 h / 20 °C
4.1: potassium carbonate / dimethyl sulfoxide / 0.5 h / 80 °C
4.2: 5 h / 20 °C
5.1: potassium carbonate / dimethyl sulfoxide / 0.5 h / 80 °C
5.2: 20 °C
With thionyl chloride; sodium dithionite; potassium carbonate; sodium hydroxide; In methanol; dichloromethane; dimethyl sulfoxide; acetone; 1.1: Marschalk type reaction;
emodin-6,8-di-O-methyl ether
5018-84-8

emodin-6,8-di-O-methyl ether

5-fluoro-3-(2-fluorobenzyl)-1-((1,6,8-trimethoxy-3-methyl-9,10-dioxo-9,10-dihydroanthracen-2-yl)methyl)pyrimidine-2,4(1H,3H)-dione
1354568-82-3

5-fluoro-3-(2-fluorobenzyl)-1-((1,6,8-trimethoxy-3-methyl-9,10-dioxo-9,10-dihydroanthracen-2-yl)methyl)pyrimidine-2,4(1H,3H)-dione

Conditions
Conditions Yield
Multi-step reaction with 5 steps
1.1: sodium dithionite; sodium hydroxide / methanol / 0.5 h / 0 °C
2.1: potassium carbonate / acetone / 16 h / Reflux
3.1: thionyl chloride / dichloromethane / 0.5 h / 20 °C
4.1: potassium carbonate / dimethyl sulfoxide / 0.5 h / 80 °C
4.2: 5 h / 20 °C
5.1: potassium carbonate / dimethyl sulfoxide / 0.5 h / 80 °C
5.2: 20 °C
With thionyl chloride; sodium dithionite; potassium carbonate; sodium hydroxide; In methanol; dichloromethane; dimethyl sulfoxide; acetone; 1.1: Marschalk type reaction;
emodin-6,8-di-O-methyl ether
5018-84-8

emodin-6,8-di-O-methyl ether

5-fluoro-3-(3-fluorobenzyl)-1-((1,6,8-trimethoxy-3-methyl-9,10-dioxo-9,10-dihydroanthracen-2-yl)methyl)pyrimidine-2,4(1H,3H)-dione
1354568-83-4

5-fluoro-3-(3-fluorobenzyl)-1-((1,6,8-trimethoxy-3-methyl-9,10-dioxo-9,10-dihydroanthracen-2-yl)methyl)pyrimidine-2,4(1H,3H)-dione

Conditions
Conditions Yield
Multi-step reaction with 5 steps
1.1: sodium dithionite; sodium hydroxide / methanol / 0.5 h / 0 °C
2.1: potassium carbonate / acetone / 16 h / Reflux
3.1: thionyl chloride / dichloromethane / 0.5 h / 20 °C
4.1: potassium carbonate / dimethyl sulfoxide / 0.5 h / 80 °C
4.2: 5 h / 20 °C
5.1: potassium carbonate / dimethyl sulfoxide / 0.5 h / 80 °C
5.2: 20 °C
With thionyl chloride; sodium dithionite; potassium carbonate; sodium hydroxide; In methanol; dichloromethane; dimethyl sulfoxide; acetone; 1.1: Marschalk type reaction;
emodin-6,8-di-O-methyl ether
5018-84-8

emodin-6,8-di-O-methyl ether

2-((5-fluoro-2,6-dioxo-3-((1,6,8-trimethoxy-3-methyl-9,10-dioxo-9,10-dihydroanthracen-2-yl)methyl)-2,3-dihydropyrimidin-1(6H)-yl)methyl)benzonitrile
1354568-88-9

2-((5-fluoro-2,6-dioxo-3-((1,6,8-trimethoxy-3-methyl-9,10-dioxo-9,10-dihydroanthracen-2-yl)methyl)-2,3-dihydropyrimidin-1(6H)-yl)methyl)benzonitrile

Conditions
Conditions Yield
Multi-step reaction with 5 steps
1.1: sodium dithionite; sodium hydroxide / methanol / 0.5 h / 0 °C
2.1: potassium carbonate / acetone / 16 h / Reflux
3.1: thionyl chloride / dichloromethane / 0.5 h / 20 °C
4.1: potassium carbonate / dimethyl sulfoxide / 0.5 h / 80 °C
4.2: 5 h / 20 °C
5.1: potassium carbonate / dimethyl sulfoxide / 0.5 h / 80 °C
5.2: 20 °C
With thionyl chloride; sodium dithionite; potassium carbonate; sodium hydroxide; In methanol; dichloromethane; dimethyl sulfoxide; acetone; 1.1: Marschalk type reaction;
emodin-6,8-di-O-methyl ether
5018-84-8

emodin-6,8-di-O-methyl ether

isorhodoptilometrin
15979-75-6,60993-95-5

isorhodoptilometrin

Conditions
Conditions Yield
Multi-step reaction with 6 steps
1: (i) K2CO3, acetone, (ii) H2O
2: NBS, (PhCO)2O2 / CCl4
3: (i) Ph3P, benzene, (ii) /BRN= 505984/, NaOMe, DMF
4: Py*HCl, aq. HCl
5: Py
6: (i) Hg(OAc)2, aq. HClO4, THF, (ii) NaOH, NaBH4
With pyridine; hydrogenchloride; N-Bromosuccinimide; pyridine hydrochloride; dibenzoyl peroxide; In tetrachloromethane;

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