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503-09-3

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503-09-3 Usage

Chemical Properties

clear colourless liquid

Uses

Epifluorohydrin is used as a reagent in the synthesis of N-arylphosphoramidates. In addition, it is used in the synthesis of orally bioavailable ALK inhibitors in the treatment of tumors.

General Description

Clear colorless liquid.

Air & Water Reactions

Highly flammable. Water soluble.

Reactivity Profile

A halogenated epoxide. Epoxides are highly reactive. They polymerize in the presence of catalysts or when heated. These polymerization reactions can be violent. Compounds in this group react with acids, bases, and oxidizing and reducing agents. They react, possibly violently with water in the presence of acid and other catalysts. The chlorinated derivative has been shown to be incompatible with aniline, strong oxidizers, sulfuric acid, isopropylamine, zinc, aluminum, iron, etc. see epichlorohydrin.

Health Hazard

ACUTE/CHRONIC HAZARDS: Epifluorohydrin is a lacrimator. When heated to decomposition it emits toxic fumes.

Fire Hazard

Epifluorohydrin is flammable.

Check Digit Verification of cas no

The CAS Registry Mumber 503-09-3 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 5,0 and 3 respectively; the second part has 2 digits, 0 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 503-09:
(5*5)+(4*0)+(3*3)+(2*0)+(1*9)=43
43 % 10 = 3
So 503-09-3 is a valid CAS Registry Number.
InChI:InChI=1/C3H5FO/c4-1-3-2-5-3/h3H,1-2H2/t3-/m1/s1

503-09-3 Well-known Company Product Price

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  • (Code)Product description
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  • Aldrich

  • (E1101)  Epifluorohydrin  98%

  • 503-09-3

  • E1101-1G

  • 693.81CNY

  • Detail

503-09-3SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 13, 2017

Revision Date: Aug 13, 2017

1.Identification

1.1 GHS Product identifier

Product name Epifluorohydrin

1.2 Other means of identification

Product number -
Other names 1,2-epoxy-3-fluoro-propane

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:503-09-3 SDS

503-09-3Relevant articles and documents

PROCESS FOR MANUFACTURING AN EPOXIDE

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Page/Page column 26-30, (2015/07/07)

Process for manufacturing an epoxide by reacting at least one chlorohydrin with at least one dehydrochlorinating agent in order to give the epoxide and at least one chlorinated co-product, said process comprising regenerating the dehydrochlorinating agent from the chlorinated co-product by a treatment which does not comprise an electrolysis operation.

SYNTHESIS OF ISOMERIC N-(3-FLUORO-2-HYDROXYPROPYL) AND N-(2-FLUORO-3-HYDROXYPROPYL) DERIVATIVES OF PURINE AND PYRIMIDINE BASES

Jindrich, Jindrich,Dvorakova, Hana,Holy, Antonin

, p. 1466 - 1482 (2007/10/02)

Reaction of fluoromethyloxirane (III) with heterocyclic bases in the presence of potassium carbonate afforded N-(3-fluoro-2-hydroxypropyl) derivatives of adenine (VI), 3-deazaadenine (VII), 2-amino-6-chloropurine (XII), 6-nitro-1-deazapurine (IX), 4-methoxy-2-pyrimidone (XVIII) and its 5-methyl derivative (XIX).Acid hydrolysis of compounds XII, XVIII, and XIX gave 9-(3-fluoro-2-hydroxypropyl)guanine (XIII), 1-(3-fluoro-2-hydroxypropyl)uracil (XX) and -thymine (XXI).The intermediates XVIII and XIX were ammonolyzed to give 1-(3-fluoro-2-hydroxypropyl)cytosine (XXII) and -5-methylcytosine (XXIII).Reaction of chloro derivative XII with sodium azide followed by hydrogenation of the formed 2-amino-6-azidopurine (XIV) led to 9-(3-fluoro-2-hydroxypropyl)-2,6-diaminopurine (XV), 9-(3-fluoro-2-hydroxypropyl)-1-deazaadenine (X) was obtained by hydrogenation of compound IX.Benzyloxymethyloxirane (XXIV) was reacted with pyridine-hydrogen fluoride adduct to give 3-benzyloxy-2-fluoropropanol (XXV) whose tosylate XXVI on reaction with sodium salt of adenine and subsequent hydrogenolysis of the intermediate XXVII afforded 9-(2-fluoro-3-hydroxypropyl)adenine (XXVIII).The same compound was obtained by reaction of 3-benzoyloxy-1-bromo-2-fluoropropanol (XXX) with sodium salt of adenine followed by methanolysis.Condensation of sodium salt of XI, XVI, and XVII with synthon XXX and subsequent acid deblocking gave 9-(2-fluoro-3-hydroxypropyl)guanine (XXXIII), 1-(2-fluoro-3-hydroxypropyl)uracil (XXXVI), and 1-(2-fluoro-3-hydroxypropyl)thymine (XXXVII). 1-(2-Fluoro-3-hydroxypropyl) derivatives of cytosine (XXXVIII) and 5-methylcytosine (XXXIX) were obtained by ammonolysis of the corresponding 4-methoxypyrimidine intermediates XXXIV and XXXV.

The Combination of Potassium Fluoride and Calcium Fluoride: A Useful Heterogeneous Fluorinating Reagent

Ichihara, Junko,Matsuo, Toshiya,Hanafusa, Terukiyo,Ando, Takashi

, p. 793 - 794 (2007/10/02)

The combination of potassium fluoride and calcium fluoride was found to be an effective and practical solid reagent for the fluorination of various organic chlorides and bromides under mild conditions.

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