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503-38-8

503-38-8

Identification

Synonyms:Formicacid, chloro-, trichloromethyl ester (6CI,7CI,8CI); Methanol, trichloro-,chloroformate (8CI); Diphosgen; Diphosgene; Trichloromethyl chlorocarbonate;Trichloromethyl chloroformate

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Safety information and MSDS view more

  • Pictogram(s):

  • Hazard Codes:T+,Xi

  • Signal Word:Danger

  • Hazard Statement:H300 Fatal if swallowedH314 Causes severe skin burns and eye damage H330 Fatal if inhaled

  • First-aid measures: General adviceConsult a physician. Show this safety data sheet to the doctor in attendance.If inhaled If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician. In case of skin contact Wash off with soap and plenty of water. Consult a physician. In case of eye contact Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician. If swallowed Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.

  • Fire-fighting measures: Suitable extinguishing media Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide. Wear self-contained breathing apparatus for firefighting if necessary.

  • Accidental release measures: Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. For personal protection see section 8. Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided. Pick up and arrange disposal. Sweep up and shovel. Keep in suitable, closed containers for disposal.

  • Handling and storage: Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Avoid exposure - obtain special instructions before use.Provide appropriate exhaust ventilation at places where dust is formed. For precautions see section 2.2. Store in cool place. Keep container tightly closed in a dry and well-ventilated place.

  • Exposure controls/personal protection:Occupational Exposure limit valuesBiological limit values Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday. Eye/face protection Safety glasses with side-shields conforming to EN166. Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU). Skin protection Wear impervious clothing. The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace. Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique(without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it. Respiratory protection Wear dust mask when handling large quantities. Thermal hazards

Supplier and reference price

  • Manufacture/Brand
  • Product Description
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  • Manufacture/Brand:TRC
  • Product Description:Trichloromethyl chloroformate
  • Packaging:25g
  • Price:$ 105
  • Delivery:In stock
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  • Manufacture/Brand:Sigma-Aldrich
  • Product Description:Trichloromethyl chloroformate ≥97.0% (GC)
  • Packaging:50ml
  • Price:$ 508
  • Delivery:In stock
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  • Manufacture/Brand:Sigma-Aldrich
  • Product Description:Trichloromethyl chloroformate ≥97.0% (GC)
  • Packaging:10ml
  • Price:$ 112
  • Delivery:In stock
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  • Manufacture/Brand:Oakwood
  • Product Description:Trichloromethyl chloroformate 98%
  • Packaging:1Kg
  • Price:$ 993
  • Delivery:In stock
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  • Manufacture/Brand:Oakwood
  • Product Description:Trichloromethyl chloroformate 98%
  • Packaging:5g
  • Price:$ 15
  • Delivery:In stock
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  • Manufacture/Brand:Medical Isotopes, Inc.
  • Product Description:Trichloromethyl chloroformate
  • Packaging:25 g
  • Price:$ 625
  • Delivery:In stock
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  • Manufacture/Brand:Biosynth Carbosynth
  • Product Description:Diphosgene
  • Packaging:25 g
  • Price:$ 75
  • Delivery:In stock
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  • Manufacture/Brand:Biosynth Carbosynth
  • Product Description:Diphosgene
  • Packaging:500 g
  • Price:$ 600
  • Delivery:In stock
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  • Manufacture/Brand:Biosynth Carbosynth
  • Product Description:Diphosgene
  • Packaging:250 g
  • Price:$ 450
  • Delivery:In stock
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  • Manufacture/Brand:Biosynth Carbosynth
  • Product Description:Diphosgene
  • Packaging:100 g
  • Price:$ 200
  • Delivery:In stock
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Relevant articles and documentsAll total 7 Articles be found

Synthesis of Some Aromatic Diisocyanides with Trichloromethyl Chloroformate

Efraty, Avi,Feinstein, Irene,Wackerle, Lorenz,Goldman, Alexander

, p. 4059 - 4061 (1980)

-

Method and device for the production of phosgene from diphosgene and/or triphosgene

-

, (2008/06/13)

The invention concerns a method for preparing phosgene from diphosgene and/or triphosgene, by reaction on a catalyst comprising one or several compounds with one or several nitrogen atoms with a pair of deactivated electrons. The invention further concerns a device for preparing phosgene from diphosgene and/or triphosgene, for implementing said method.

Water-mediated proton transfer: A mechanistic investigation on the example of the hydration of sulfur oxides

Loerting, Thomas,Liedl, Klaus R.

, p. 5137 - 5145 (2007/10/03)

We outline general mechanistic features of "water-mediated proton transfer" in the example of the isomerization reaction in hydrogen-bonded sulfur oxide-water supermolecules containing up to three water molecules. The nucleophilic attack of a water oxygen on the sulfur atom occurs concertedly with the (multiple) protontransfer event(s). The protons are transferred according to the well-known hydrogen-bond compression mechanism. However, contrary to "pure" multiple proton-transfer reactions, the protons are transferred asynchronously. These mechanistic features force the reaction to be classical rather than quantum-tunneling-dominated down to rather low temperatures. In the quantum-dominated temperature region, tunneling takes place only if all protons tunnel through the barrier. Straight line corner cutting (large curvature tunneling) does not dominate at any temperature, as the reduced mass corresponding to reaction coordinate motion does not drop to values low enough in the reaction barrier region. The asymmetric nature of the potential energy surface even allows different mechanisms involving transient H3O+ rotation termed "molecular swing" and a H2SO3 isomerization to be favorable compared to water-mediated triple proton transfer in the case of three participating water molecules.

Process for preparing cyclopropylacetylene

-

, (2008/06/13)

The invention relates to a process for the halogenation of cyclopropylmethyl ketone with at least one dihalo-triorganophosphorane of the general formula I R3PHal2??(I), in which the radicals R can be the same or different and denote a saturated or unsaturated aliphatic C1-C20hydrocarbon radical, a phenyl or (C1-C4alkyl)phenyl radical, which may be optionally substituted by one or two fluorine, chlorine and/or nitro groups, P stands for phosphorus and Hal denotes chlorine, bromine, or iodine, at a temperature of from 800° to 130° C., where the dihalo-triorganophosphane of the general formula (I) is synthesized in situ from triorganophosphane oxide or triorganophosphane sulfide of the general formula II R3PA ??(II), in which R is as defined above with respect to formula I and A denotes oxygen or sulfur, using a halogenating agent, wherein the triorganophosphane oxide or triorganophosphane sulfide is used in catalytic amounts, to the halogenation product of cyclopropylmethyl ketone obtained in said process, and to a process for the conversion of said halogenation product to cyclopropylacetytene.

Conversion of bis(trichloromethyl), carbonate to phosgene and reactivity of triphosgene, diphosgene, and phosgene with methanol

Pasquato,Modena,Cotarca,Delogu,Mantovani

, p. 8224 - 8228 (2007/10/03)

Triphosgene was decomposed quantitatively to phosgene by chloride ion. The reaction course was monitored by IR spectroscopy (React-IR), showing that diphosgene was an intermediate. The methanolysis of triphosgene in deuterated chloroform, monitored by proton NMR spectroscopy, gave methyl chloroformate and methyl 1,1,1-trichloromethyl carbonate in about a 1:1 ratio, as primary products. The reaction carried out in the presence of large excess of methanol (0.3 M, 30 equiv) was a pseudo-first-order process with a k(obs) of 1.0 x 10-4 s-1. Under the same conditions, values of k(obs) of 0.9 x 10-3 s-1 and 1.7 x 10-2 s-1 for the methanolysis of diphosgene and phosgene, respectively, were determined. The experimental data suggest that, under these conditions, the maximum concentration of phosgene during the methanolysis of triphosgene and diphosgene was lower than 1 x 10-5 M. Methyl 1,1,1-trichloromethyl carbonate was synthesized and characterized also by the APCI-MS technique.

5'-O-Dans EOC modified nucleosides and methods for preparing same

-

, (2008/06/13)

Dansylethoxycarbonyl (Dans-EOC) groups which can be employed as base-labile 5'hydroxyl protective groups in chemical oligonucleotide synthesis are disclosed. These groups allow the preparation of a compound of the formula (I) STR1 which comprises reacting the compound of the formula (II) STR2 with a chlorocarbonyl donor.

Process route upstream and downstream products

Process route

methyl chloroformate
79-22-1

methyl chloroformate

trichloromethyl chloroformate
503-38-8

trichloromethyl chloroformate

Conditions
Conditions Yield
With chlorine; at 75 - 85 ℃; for 35h;
84%
bei Chlorierung im Sonnenlicht;
bei der Chlorierung schliesslich;
bei der Chlorierung im UV-Licht; die Bildungsgeschwindigkeit waechst mit steigender Temperatur bis 110-112grad;
beim Chlorieren im Sonnenlicht;
Methyl formate
107-31-3

Methyl formate

trichloromethyl chloroformate
503-38-8

trichloromethyl chloroformate

Conditions
Conditions Yield
bei der Chlorierung im UV-Licht; die Bildungsgeschwindigkeit waechst mit steigender Temperatur bis 110-112grad;
beim Chlorieren im Sonnenlicht;
With diacetyl peroxide; chlorine; at 60 ℃; unter Ausschluss von Licht;
durch photochemische Chlorierung;
With chlorine; im Licht einer Metallfadenlampe;
carbonochloridic acid, chloromethyl ester
22128-62-7

carbonochloridic acid, chloromethyl ester

dichloromethoxycarbonyl chloride
22128-63-8

dichloromethoxycarbonyl chloride

trichloromethyl chloroformate
503-38-8

trichloromethyl chloroformate

Conditions
Conditions Yield
With chlorine; for 61h;
76%
With chlorine; for 61h; Yields of byproduct given;
bis(trichloromethyl) carbonate
32315-10-9

bis(trichloromethyl) carbonate

phosgene
75-44-5

phosgene

trichloromethyl chloroformate
503-38-8

trichloromethyl chloroformate

Conditions
Conditions Yield
beim Destillieren;
beim Destillieren;
With chloride; In hexane; at 20 ℃; Kinetics;
distn. or warming at reflux cooling;
Methyl formate
107-31-3

Methyl formate

dichloromethoxycarbonyl chloride
22128-63-8

dichloromethoxycarbonyl chloride

carbonochloridic acid, chloromethyl ester
22128-62-7

carbonochloridic acid, chloromethyl ester

trichloromethyl chloroformate
503-38-8

trichloromethyl chloroformate

Conditions
Conditions Yield
Bei der Chlorierung im Licht;
With oxygen; chlorine; at 22.85 ℃; Further Variations:; Reagents; Kinetics;
bis(trichloromethyl) carbonate
32315-10-9

bis(trichloromethyl) carbonate

trichloromethyl chloroformate
503-38-8

trichloromethyl chloroformate

Conditions
Conditions Yield
Methyl formate
107-31-3

Methyl formate

chlorine
7782-50-5

chlorine

trichloromethyl chloroformate
503-38-8

trichloromethyl chloroformate

Conditions
Conditions Yield
mit ueberschuessigem Chlor;
im Sonnenlicht entsteht zunaechst Chlorameisensaeuremethylester;
mit ueberschuessigem Chlor;
trichloromethyl chloroformate
503-38-8

trichloromethyl chloroformate

Conditions
Conditions Yield
Darstellung im grossen;
technische Darstellung;
4-nitro-aniline
100-01-6,104810-17-5

4-nitro-aniline

trichloromethyl chloroformate
503-38-8

trichloromethyl chloroformate

4-Nitrophenyl isocyanate
100-28-7

4-Nitrophenyl isocyanate

Conditions
Conditions Yield
In ethyl acetate; 1.) 40 - 50 deg C, 1 h, 2.) 80 deg C, 2 h;
With pyrographite; In ethyl acetate; Heating;
cyclohexylamine
108-91-8,157973-60-9

cyclohexylamine

trichloromethyl chloroformate
503-38-8

trichloromethyl chloroformate

Cyclohexyl isocyanate
3173-53-3

Cyclohexyl isocyanate

Conditions
Conditions Yield
With pyrographite; In ethyl acetate; Heating;

Global suppliers and manufacturers

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  • Amadis Chemical Co., Ltd.
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  • Chemwill Asia Co., Ltd.
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  • Contact Tel:021-51086038
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  • Kono Chem Co.,Ltd
  • Business Type:Other
  • Contact Tel:86-29-86107037-8015
  • Emails:info@konochemical.com
  • Main Products:82
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  • GIHI CHEMICALS CO.,LIMITED
  • Business Type:Lab/Research institutions
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  • Country:China (Mainland)
  • Hangzhou Dingyan Chem Co., Ltd
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  • Contact Tel:86-571-86465881,86-571-87157530,86-571-88025800
  • Emails:sales@dingyanchem.com
  • Main Products:95
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  • Aecochem Corp.
  • Business Type:Manufacturers
  • Contact Tel:+86-592 599 8717
  • Emails:sales@aecochemical.com
  • Main Products:70
  • Country:China (Mainland)
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