50375-15-0

Basic information

• Product Name: N-[4-(2-hydroxyethoxy)phenyl]acetamide
• Synonyms: N-[4-(2-hydroxyethoxy)phenyl]acetamide;O-(2-Hydroxyethyl)paracetamol;p-(2-Hydroxyethoxy)acetanilide;N-[4-(Hydroxyethoxy)phenyl]ethanamide
• CAS NO: 50375-15-0
• Molecular Formula: C₁₀H₁₃NO₃
• Molecular Weight: 195.21512
• EINECS: 256-562-4
• Mol File: 50375-15-0.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 432.6°C at 760 mmHg
• Flash Point: 215.4°C
• Appearance: /
• Density: 1.216g/cm³
• Vapor Pressure: 2.99E-08mmHg at 25°C
• Refractive Index: 1.579
• CAS DataBase Reference: N-[4-(2-hydroxyethoxy)phenyl]acetamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-[4-(2-hydroxyethoxy)phenyl]acetamide(50375-15-0)
• EPA Substance Registry System: N-[4-(2-hydroxyethoxy)phenyl]acetamide(50375-15-0)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 50375-15-0(Hazardous Substances Data)

Usage

Uses

N-[4-(2-Hydroxyethoxy)phenyl]acetamide is an intermediate in the synthesis of N-[4-(2-Chloroethoxy)phenyl]-methanesulfonamide (C371290), which is an impurity of Dofetilide (D525700), a potassium channel blocker.

InChI:InChI=1/C10H13NO3/c1-8(13)11-9-2-4-10(5-3-9)14-7-6-12/h2-5,12H,6-7H2,1H3,(H,11,13)

Upstream product

• 103-90-2 4-acetaminophenol 
• 107-07-3 2-chloro-ethanol 
• 540-51-2 2-bromoethanol 
• 107-21-1 ethylene glycol 
• 103-84-4 Acetanilid 
• 93930-27-9 Carbonic acid 2-(4-acetylamino-phenoxy)-ethyl ester benzyl ester 
• 75-21-8 oxirane 

Downstream Products

• 6421-88-1 2-(4-aminophenoxy)ethanol 
• 38519-26-5 [4-(2-chloro-ethoxy)-phenyl]-(5-methoxy-benzothiazol-2-yl)-amine 
• 28276-96-2 acetic acid-[4-(2-diethylamino-ethoxy)-anilide] 
• 96116-29-9 N-(4-(2-(dimethylamino)ethoxy)phenyl)acetamide 
• 59954-07-3 acetic acid-[4-(2-piperidino-ethoxy)-anilide] 
• 38948-27-5 4-(2-(piperidin-1-yl)ethoxy)aniline 
• 401514-13-4 4-[2-(3-benzyl-3,8-diaza-bicyclo[3.2.1]oct-8-yl)-ethoxy]-phenylamine 
• 27692-35-9 4-(2'-chloroethoxy)-aniline 
• 96740-81-7 1-acetoxy-2-(4-acetylamino-phenoxy)-ethane 
• 36616-28-1 2-(4-acetamidophenoxy)ethyl chloride 

Relevant articles and documents

Direct acetoxylation and etherification of anilides using phenyliodine bis(trifluoroacetate)

Treatment of various anilides with 1.5 equiv. of phenyliodine bis(trifluoroacetate) (PIFA) and 1.0 equiv. of BF3·OEt 2 in AcOH at room temperature afforded the corresponding para-acetoxylated products with high regioselectivity. In addition, this reaction could be expanded to the etherification of anilides. In the presence of 2.0 equiv. of PIFA and 2.0 equiv. of BF3·OEt2, the reaction of anilides with alcohols provided the corresponding para-etherified products in good yields. The Royal Society of Chemistry 2011.

Syntheses of Reactive Fluorescent Stains Derived from 5(2)-Aryl-2(5)-(4-pyridyl)oxazoles and Bifunctionally Reactive Linkers

Several bifunctionally reactive linkers containing halide or sulfonate ester groups were prepared.The linkers were used to quaternize 5-(4-methoxyphenyl)-2-(4-pyridyl)oxazole and 2-(6-chromanyl)-5-(4-pyridyl)oxazole to produce fluorescent stains that contained a reactive group such as an isothiocyanate, an N-hydroxysuccinimidyl ester, a maleimide, or an oxirane.The stains were derivatized with either 1-propyl-amine, 1-propanethiol, or piperidine, as appropriate, to help in characteriazation.The stains may serve as more photostable alternatives to fluoresceins or coumarins.

5-Substituted pyrimidine derivatives active against internal animal parasites

The invention concerns a process for killing internal parasites, especially trematodes or nematodes, affecting warm blooded animals such as cattle, sheep and goats by administering an effective amount of a composition containing as active ingredient a compound of the formula STR1 Certain of the compounds of formula I are novel and in further embodiments the invention provides novel compounds and compositions for use in the process of the invention. The process of the invention is especially applicable to the tretment of warm blooded animals infected with the trematodes Fasciola hepatica (liver fluke).