50675-18-8

Basic information

• Product Name: Tetrahydropyran-4-carbaldehyde
• Synonyms: 4-FORMYLTETRAHYDROPYRAN;TETRAHYDRO-2H-PYRAN-4-CARBALDEHYDE;TETRAHYDRO-PYRAN-4-CARBALDEHYDE;TETRAHYDROPYRANYL-4-CARBOXALDEHYDE;Tetrahydro-2H-pyran-4-carboxaldehyde;Tetrahydropyran-4-carboxaldehyde;Tetrahydropyran-4-carboxaldehyde 95%;TETRAHYDRO-PYRAN-4-CARBALDEHYD
• CAS NO: 50675-18-8
• Molecular Formula: C₆H₁₀O₂
• Molecular Weight: 114.14
• Product Categories: Aldehydes;blocks;Heterocycles;Building Blocks;Pyran
• Mol File: 50675-18-8.mol
• Article Data: 33

Chemical Properties

• Boiling Point: 176.921 °C at 760 mmHg
• Flash Point: >23℃
• Appearance: /
• Density: 1.097 g/cm³
• Vapor Pressure: 1.067mmHg at 25°C
• Refractive Index: 1.513
• Storage Temp.: Keep Cold
• CAS DataBase Reference: Tetrahydropyran-4-carbaldehyde(CAS DataBase Reference)
• NIST Chemistry Reference: Tetrahydropyran-4-carbaldehyde(50675-18-8)
• EPA Substance Registry System: Tetrahydropyran-4-carbaldehyde(50675-18-8)

Safety Data

• Hazard Codes: Xi
• Statements: 36-20/21/22
• Safety Statements: 26-36/37-24/25
• RIDADR: 1993
• Hazardous Substances Data: 50675-18-8(Hazardous Substances Data)

Usage

Chemical Properties

Colorless liquid

Uses

4-Formyltetrahydropyran is used in preparation of the heterocyclic compounds and their medical applications.

InChI:InChI=1/C6H10O2/c7-5-6-1-3-8-4-2-6/h5-6H,1-4H2

Upstream product

• 185-72-8 1,6-dioxa-spiro[2.5]octane 
• 5435-44-9 (E)-3-Ureido-but-2-enoic acid ethyl ester 
• 14774-37-9 (tetrahydro-2H-pyran-4-yl)methanol 
• 5337-03-1 tetrahydro-2H-pyran-4-carboxylic acid 
• 110238-91-0 tetrahydropyran-4-carboxylic acid methyl ester 
• 6192-52-5 p-toluenesulfonic acid monohydrate 
• 144-55-8 sodium hydrogencarbonate 
• 101765-10-0 tetrahydro-4-(methoxymethylene)-2H-pyran 
• 50-00-0 formaldehyd 
• 96835-17-5 ethyl tetrahydro-2H-pyran-4-carboxylate 
• 4295-99-2 tetrahydro-2H-pyran-4-carbonitrile 
• 29943-42-8 Tetrahydro-4H-pyran-4-one 
• 40191-32-0 tetrahydro-2H-pyran-4-carbonylchloride 
• 2081-44-9 Tetrahydro-pyran-4-ol 

Downstream Products

• 53284-84-7 2-amino-2-(oxan-4-yl)acetic acid 
• 216087-92-2 rac-(tetrahydro-2H-pyran-4-yl)(phenyl)methanol 
• 98337-80-5 tetrahydro-pyran-4-carbaldehyde semicarbazone 
• 104912-18-7 tetrahydro-pyran-4-carbaldehyde-(2,4-dinitro-phenylhydrazone) 
• 99228-16-7 tetrahydropyran-4-yl-acrylic acid ethyl ester 
• 265108-10-9 2-(tetrahydro-pyran-4-ylmethylene)-malononitrile 
• 5337-03-1 tetrahydro-2H-pyran-4-carboxylic acid 
• 947373-34-4 5-amino-6-bromo-N-{[1-(tetrahydro-2H-pyran-4-ylmethyl)-4-piperidinyl]methyl}-3,3-dihydro-2H-chromene-8-carboxamide 
• 582299-19-2 2-hydroxy-1-phenyl-2-(3,4,5,6-tetrahydro-2H-pyran-4-yl) ethan-1-one 
• 582299-04-5 2-oxo-2-phenyl-1-(3,4,5,6-tetrahydro-2H-pyran-4-yl)ethyl 4-methylbenzene-1-sulfonate 
• 870082-27-2 3-(4-formyltetrahydro-2H-pyran-4-yl)propanenitrile 
• 910910-88-2 4-((3-methyl-3H-imidazol-4-ylmethyl)-{2-[(tetrahydropyran-4-ylmethyl)amino]ethyl}amino)benzonitrile 
• 915381-25-8 5-bromo-N-3-(tetrahydro-2H-pyran-4-ylmethyl)pyridine-2,3-diamine 
• 935696-99-4 1,1-dimethylethyl {[1-(tetrahydro-2H-pyran-4-ylmethyl)-4-piperidinyl]methyl}carbamate 

Relevant articles and documents

SULFONYL-SUBSTITUTED BICYCLIC COMPOUND WHICH ACTS AS ROR INHIBITOR

Provided is a sulfonyl-substituted bicyclic compound (A) which acts as a RORγ inhibitor, said compound has good RORγ inhibitory activity and is expected to be used for treating diseases mediated by a RORγ receptor in mammals.

Synthesis method of 4-ethynyl-tetrahydropyran or 4-ethynyl piperidine

The invention relates to the technical field of organic synthesis. For solving the problems that a conventional synthesis method of 4-ethynyl-tetrahydropyran and 4-ethynyl piperidine is complex in operation, high in cost and unsuitable for industrial production in the prior art, the invention provides a synthesis method of 4-ethynyl-tetrahydropyran or 4-ethynyl piperidine, wherein the synthesis method comprises the following steps: carrying out Wittig reaction on carbonyl of a compound represented by the formula (I) and phosphorus ylide salt under the action of a strong alkali to generate a compound represented by the formula (II), wherein the reaction temperature is 0-50 DEG C; (2) hydrolyzing the compound represented by the formula (II) to generate a compound represented by the formula (III), wherein the reaction temperature is 20-60 DEG C; (3) carrying out a Corey-Fuchs reaction on the compound represented by the formula (III) to obtain a compound represented by the formula (IV), wherein the reaction temperature is -20 to 40 DEG C; and (4) carrying out a reaction of the compound represented by the formula (IV) with a strong alkali, and carrying out a reaction with a silica reagent to generate a compound represented by the formula (V), wherein the reaction temperature is -70 to 20 DEG C. The method has the advantages of simple and accessible raw materials, low cost, simple synthesis steps and high yield, and is suitable for laboratory small-scale preparation and industrial production.

Polysubstituted-indazole compounds and application of same as IDO inhibitors

The invention discloses polysubstituted-indazole compounds as shown in a formula (I) which is described in the specification, a preparation method for the compounds, and application of the compounds as IDO inhibitors. The compounds provided by the invention can be used for preventing and/or treating a plurality of diseases, such as Alzheimer's disease, cataract, infections related to cellular immune activation, autoimmune diseases, AIDS, cancers, depression, the metabolic disorder of tryptophan or the like.