50739-76-9

Basic information

• Product Name: 2-AMINO-3,5-DIBROMOBENZYL ALCOHOL
• Synonyms: RARECHEM AL BD 0466;2-Amino-3,5-dibromo-benzenemethanol;2-AMINO-3,5-DIBROMOBENZYL ALCOHOL;3,5-DIBROMO-2-AMINO BENZYL ALCOHOL;3,5-Dibromo-2-amino;2-AMino-3,5-dibroMobenzyl benzoic alcohol;BenzeneMethanol, 2-aMino-3,5-dibroMo-;(2-aMino-3,5-dibroMophenyl)Methanol
• CAS NO: 50739-76-9
• Molecular Formula: C₇H₇Br₂NO
• Molecular Weight: 280.94
• Product Categories: Amines;Aromatics;Miscellaneous Reagents
• Mol File: 50739-76-9.mol
• Article Data: 6

Chemical Properties

• Melting Point: 146-148°C
• Boiling Point: 366.294 °C at 760 mmHg
• Flash Point: 175.328 °C
• Appearance: White to off-white solid
• Density: 2.037 g/cm³
• Vapor Pressure: 5.21E-06mmHg at 25°C
• Refractive Index: 1.683
• Storage Temp.: Refrigerator
• Solubility: Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
• PKA: 13.83±0.10(Predicted)
• CAS DataBase Reference: 2-AMINO-3,5-DIBROMOBENZYL ALCOHOL(CAS DataBase Reference)
• NIST Chemistry Reference: 2-AMINO-3,5-DIBROMOBENZYL ALCOHOL(50739-76-9)
• EPA Substance Registry System: 2-AMINO-3,5-DIBROMOBENZYL ALCOHOL(50739-76-9)

Safety Data

• Hazardous Substances Data: 50739-76-9(Hazardous Substances Data)

Usage

Chemical Properties

White to Off-White Solid

Uses

Byproduct of Ambroxol synthesis. An impurity arising in the synthesis of Bromhexine (B678600).

InChI:InChI=1/C7H7Br2NO/c8-5-1-4(3-11)7(10)6(9)2-5/h1-2,11H,3,10H2

Upstream product

• 606-00-8 2-amino-3,5-dibromo-benzoic acid methyl ester 
• 134-20-3 2-carbomethoxyaniline 
• 50910-55-9 3,5-dibromo-2-amino benzaldehyde 

Downstream Products

• 76928-37-5 6,8-dibromo-1H-benzo[d][1,3]oxazin-2(4H)-one 
• 611-75-6 bromhexine monohydrochloride 
• 50910-55-9 3,5-dibromo-2-amino benzaldehyde 
• 3572-43-8 bromhexine 
• 18683-91-5 ambroxol 
• 860789-75-9 6,8-dibromo-2-phenylquinoline 

Relevant articles and documents

Efficient production method of bromhexine hydrochloride

The invention belongs to the technical field of biological medicines, and particularly relates to an efficient production method of bromhexine hydrochloride. The production method of bromhexine hydrochloride comprises the following steps: (1) reducing 3,5-dibromo-2-aminobenzaldehyde by a reducing agent to obtain an intermediate 3,5-dibromo-2-aminobenzyl alcohol; (2) reacting the intermediate 3,5-dibromo-2-aminobenzyl alcohol with N-methylcyclohexylamine, and then carrying out salt forming reaction to obtain a bromhexine hydrochloride crude product; and (3) purifying the bromhexine hydrochloride crude product to obtain the bromhexine hydrochloride.

A preparation method of bromhexine hydrochloride (by machine translation)

The invention belongs to the field of organic synthesis, provides a bromhexine hydrochloride of the preparation method. The invention relates to 2 - aminobenzoic acid ester compound as a raw material, by the bromo reaction, reduction reaction, condensatio

A preparation method of bromhexine hydrochloride

The invention provides a preparation method of bromhexine hydrochloride. 2-amino-3,5-dibromo benzaldehyde is taken as a raw material, and reduction, amination and salifying are carried out, so that the bromhexine hydrochloride is obtained, wherein amination and salifying are completed in one step, and an intermediate product is not needed to be separated. The preparation method of the bromhexine hydrochloride has the advantages that reaction steps are reduced, and yield and purity of the bromhexine hydrochloride product are improved.