50776-26-6

Basic information

• Product Name: 4-METHYL-3,4-DIHYDRO-2H-CYCLOPENTA[B]INDOL-1-ONE
• Synonyms: 4-METHYL-3,4-DIHYDRO-2H-CYCLOPENTA[B]INDOL-1-ONE;4-Methyl-3,4-dihydrocyclopenta[b]indol-1(2H)-one;4-Methyl-2,3-dihydrocyclopenta[b]indol-1(4H)-one
• CAS NO: 50776-26-6
• Molecular Formula: C12H11NO
• Molecular Weight: 185.22184
• Mol File: 50776-26-6.mol
• Article Data: 4

Chemical Properties

• Melting Point: 209-210℃
• Appearance: /
• Density: 1.25
• CAS DataBase Reference: 4-METHYL-3,4-DIHYDRO-2H-CYCLOPENTA[B]INDOL-1-ONE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-METHYL-3,4-DIHYDRO-2H-CYCLOPENTA[B]INDOL-1-ONE(50776-26-6)
• EPA Substance Registry System: 4-METHYL-3,4-DIHYDRO-2H-CYCLOPENTA[B]INDOL-1-ONE(50776-26-6)

Safety Data

• Hazardous Substances Data: 50776-26-6(Hazardous Substances Data)

Usage

General Description

4-METHYL-3,4-DIHYDRO-2H-CYCLOPENTA[B]INDOL-1-ONE, also known as Sertraline, is a selective serotonin reuptake inhibitor (SSRI) used as an antidepressant medication. It works by increasing the levels of serotonin, a neurotransmitter in the brain that helps regulate mood, emotional state, and behavior. Sertraline is commonly prescribed to treat major depressive disorder, obsessive-compulsive disorder, panic disorder, social anxiety disorder, and post-traumatic stress disorder. It is available in tablet and oral concentrate forms and is typically taken once a day, with or without food. Like all medications, Sertraline can cause side effects and should be taken under the supervision of a healthcare professional.

Upstream product

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Relevant articles and documents

C-H Activation-Based Traceless Synthesis via Electrophilic Removal of a Directing Group. Rhodium(III)-Catalyzed Entry into Indoles from N-Nitroso and α-Diazo-β-keto Compounds

A distinct C-H activation-based traceless synthetic protocol via electrophilic removal of a directing group is reported, complementing the currently exclusively used nucleophilic strategy. Rh(III)-catalyzed, N-nitroso-directed C-H activation allows the development of a traceless, atom- and step-economic, cascade approach for the synthesis of indole skeletons, starting from readily available N-nitroso and α-diazo-β-keto compounds. Importantly, the cyclization/denitrosation reaction represents a hitherto unobserved reactivity pattern for the N-nitroso group.

Synthesis of Cyclopenta[b]indol-1-ones and Carbazol-4-ones from N-(2-Halophenyl)-Substituted Enaminones by Intramolecular Heck Reaction

An efficient synthetic route towards N-methylated or nonmethylated 3,4-dihydrocyclopent[b]indol-1(2H)-ones (3) and 1,2,3,9-tetrahydrocarbazol-4(4H)-one (10) was elaborated, based on Pd-catalyzed intramolecular Heck reaction. The chemoselectivity of the cyclization was studied in the case of the bi- and trifunctional substrates 12 and 17, respectively. In the latter case, depending on the catalyst, either the brominated indole 18 or the tetracyclic compound 19 were obtained by single and double Heck reaction, respectively.