5086-43-1

Basic information

• Product Name: 2-phenyl-4-(pyridin-3-ylmethylidene)-1,3-oxazol-5(4H)-one
• CAS NO: 5086-43-1
• Molecular Formula: C₁₅H₁₀N₂O₂
• Molecular Weight: 250.2521
• Mol File: 5086-43-1.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 402.8°C at 760 mmHg
• Flash Point: 197.4°C
• Density: 1.24g/cm³
• Vapor Pressure: 1.06E-06mmHg at 25°C
• Refractive Index: 1.636
• CAS DataBase Reference: 2-phenyl-4-(pyridin-3-ylmethylidene)-1,3-oxazol-5(4H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 2-phenyl-4-(pyridin-3-ylmethylidene)-1,3-oxazol-5(4H)-one(5086-43-1)
• EPA Substance Registry System: 2-phenyl-4-(pyridin-3-ylmethylidene)-1,3-oxazol-5(4H)-one(5086-43-1)

Safety Data

• Hazardous Substances Data: 5086-43-1(Hazardous Substances Data)

Upstream product

• 500-22-1 3-pyridinecarboxaldehyde 
• 495-69-2 Hippuric Acid 

Downstream Products

• 33560-91-7 2-(benzoylamino)-3-(3-pyridinyl)-propanoic acid 
• 1334144-74-9 (5S,6R,10S)-6-(3,3-dibromoallyl)-2-phenyl-10-(pyridin-3-yl)-3-oxa-1-azaspiro[4.5]deca-1,7-dien-4-one 
• 1334144-90-9 methyl (1R,2S,6R)-1-benzamido-2-(3,3-dibromoallyl)-6-(pyridin-3-yl)cyclohex-3-enecarboxylate 
• 3688-81-1 1-(2-benzoylamino-3-pyridin-3-yl-acryloyl)-piperidine 
• 17470-24-5 2-amino-3-(pyridin-3-yl)propanoic acid 
• 5086-45-3 3-(5,5-dimethyl-2-phenyl-oxazol-4-ylidenemethyl)-pyridine 

Relevant articles and documents

Synthesis and biological activities of nicotinaldehyde based azlactones

A series of nicotinaldehyde based azlactones 3a-g, 6a-f, 11a-d, 16b-c, and 16e-f have been prepared and screened for their free radicals scavenging, a-glucosidase inhibitory and anti-proliferative activities on cell lines, namely lung adenocarcinoma (A549), human breast cancer (MCF7) and human epithelial cervical cancer (HeLa). Compound 3g is the most potent α-glucosidase inhibitor followed by compounds 6b and 6a. Compound 11b is the better DPPH and ABTS+radical scavenger. Compounds 11c-d and 16f show anti-proliferative activity on all the tested cell lines. However, compounds 16c and 16e display anti-proliferative activity on MCF7 and HeLa cell lines.