50966-74-0

Basic information

• Product Name: 2-(1H-Pyrrol-1-yl)pyridine
• Synonyms: BUTTPARK 91\18-04;1-(2-PYRIDYL)PYRROLE;2-PYRROL-1-YL-PYRIDINE;2-(1H-PYRROL-1-YL)PYRIDINE;N-(PYRID-2-YL)PYRROLE;Pyridine, 2-(1H-pyrrol-1-yl)-
• CAS NO: 50966-74-0
• Molecular Formula: C₉H₈N₂
• Molecular Weight: 144.17
• EINECS: 256-867-2
• Mol File: 50966-74-0.mol
• Article Data: 22

Chemical Properties

• Melting Point: 17 °C
• Boiling Point: 261.9 °C at 760 mmHg
• Flash Point: 112.2 °C
• Appearance: /
• Density: 1.06 g/cm³
• Vapor Pressure: 0.0183mmHg at 25°C
• Refractive Index: 1.591
• Storage Temp.: 2-8°C
• PKA: -0.06±0.19(Predicted)
• CAS DataBase Reference: 2-(1H-Pyrrol-1-yl)pyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(1H-Pyrrol-1-yl)pyridine(50966-74-0)
• EPA Substance Registry System: 2-(1H-Pyrrol-1-yl)pyridine(50966-74-0)

Safety Data

• Hazardous Substances Data: 50966-74-0(Hazardous Substances Data)

Usage

General Description

2-(1H-Pyrrol-1-yl)pyridine is a heterocyclic organic compound that incorporates both a pyrrole and pyridine ring within its structure. The molecule contains nitrogen atoms due to these ring structures. As a type of bidentate ligand, it plays a significant role in coordination chemistry, frequently being used to create more complex structures. Its physical properties, molecular weight and other characteristics should be handled with care in a laboratory setting due to potential toxicity and flammability. Its exact applications vary within the chemical and pharmaceutical industries.

InChI:InChI=1/C9H8N2/c1-2-6-10-9(5-1)11-7-3-4-8-11/h1-8H

Upstream product

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Relevant articles and documents

CYCLOMETALLATION OF A PYRROLE RING OF 2-(1-PYRROLYL)PYRIDINE WITH PALLADIUM(II) AND RHODIUM(III)

2-(1-Pyrrolyl)pyridine (Hplp) is cyclometallated with lithium tetrachloropalladate(II) and hexahalogenotetrakis(tri-n-butylphosphine)dirhodium(III) to give 2 and (X=Cl, Br; PBu3=tri-n-butylphosphine), respectively, where deprotonated plp is coordinated via the pyridine-N and pyrrole-2C atoms forming a five-membered metallacycle. 2 reacts with pyridine (py) and with PBu3 to form the adducts (L=py, PBu3) and with acetylacetone (Hacac) to afford the complex .Metathesis of with excess lithium iodide gives a mixed halogeno complex .These complexes are characterized spectroscopically.

Ultrasound-assisted bismuth nitrate-induced green synthesis of novel pyrrole derivatives and their biological evaluation as anticancer agents

A series of novel N-substituted pyrrole derivatives have been designed and synthesized following ultrasound-assisted and bismuth nitrate-catalyzed eco-friendly route. This reaction has also provided a general method to prepare diverse varieties of N-substituted pyrroles with less nucleophilic polyaromatic amines. Based on 1H NMR spectroscopy, a plausible mechanistic pathway has been advanced. Cytotoxicity of some selected N-substituted pyrrole derivatives has been evaluated in vitro in a panel of mammalian cancer cell lines which includes liver cancer cell lines (HepG2 and Hepa1-6), colon cancer cell lines (HT-29 and Caco-2), a cervical cancer cell line (HeLa) and NIH3T3 cells. Two compounds, 5-(1H-pyrrol-1-yl)-1,10-phenanthroline (9) and 1-(phenanthren-2-yl)-1H-pyrrole (10) have shown good cytotoxicity against some cancer cell lines. Furthermore, these compounds have exhibited cytotoxic specificity against liver cancer cell lines in vitro when compared with normal cultured primary hepatocytes.

Cobalt-Catalyzed Enantioselective Hydroarylation of 1,6-Enynes

An asymmetric hydroarylative cyclization of enynes involving a C-H bond cleavage is reported. The cobalt-catalyzed cascade generates three new bonds in an atom-economical fashion. The products were obtained in excellent yields and excellent enantioselectivities as single diastereo- and regioisomers. Preliminary mechanistic studies indicate that the reaction shows no intermolecular C-H crossover. This work highlights the potential of cobalt catalysis in C-H bond functionalization and enantioselective domino reactivity.

Activation Relay on Rhodium-Catalyzed C-H Aminomethylation in Cooperation with Photoredox Catalysis

A site selective C-H aminomethylation at indole's C3 position has been achieved by merging rhodium(III)-catalyzed C-H activation and photoredox catalysis in a one-pot manner. An investigation of the mechanistic insights rationalized the essence of the activation relay and the combination mode.