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Cas Database

51091-84-0

51091-84-0

Identification

  • Product Name:(2S)-2-(6-methoxynaphthalen-2-yl)propanoyl chloride

  • CAS Number: 51091-84-0

  • EINECS:

  • Molecular Weight:248.709

  • Molecular Formula: C14H13ClO2

  • HS Code:2918990090

  • Mol File:51091-84-0.mol

Synonyms:naproxen chloride;

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Safety information and MSDS view more

  • Hazard Codes:Xi

  • Signal Word:Warning

  • Hazard Statement:H319 Causes serious eye irritation

  • First-aid measures: General adviceConsult a physician. Show this safety data sheet to the doctor in attendance.If inhaled If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician. In case of skin contact Wash off with soap and plenty of water. Consult a physician. In case of eye contact Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician. If swallowed Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.

  • Fire-fighting measures: Suitable extinguishing media Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide. Wear self-contained breathing apparatus for firefighting if necessary.

  • Accidental release measures: Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. For personal protection see section 8. Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided. Pick up and arrange disposal. Sweep up and shovel. Keep in suitable, closed containers for disposal.

  • Handling and storage: Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Avoid exposure - obtain special instructions before use.Provide appropriate exhaust ventilation at places where dust is formed. For precautions see section 2.2. Store in cool place. Keep container tightly closed in a dry and well-ventilated place.

  • Exposure controls/personal protection:Occupational Exposure limit valuesBiological limit values Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday. Eye/face protection Safety glasses with side-shields conforming to EN166. Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU). Skin protection Wear impervious clothing. The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace. Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique(without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it. Respiratory protection Wear dust mask when handling large quantities. Thermal hazards

Supplier and reference price

  • Manufacture/Brand
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  • Manufacture/Brand:Sigma-Aldrich
  • Product Description:(S)-(+)-Naproxen chloride ≥97.0%
  • Packaging:5g
  • Price:$ 202
  • Delivery:In stock
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  • Manufacture/Brand:American Custom Chemicals Corporation
  • Product Description:(S)-(+)-NAPROXEN CHLORIDE 95.00%
  • Packaging:5G
  • Price:$ 900.47
  • Delivery:In stock
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  • Manufacture/Brand:American Custom Chemicals Corporation
  • Product Description:(S)-(+)-NAPROXEN CHLORIDE 95.00%
  • Packaging:1G
  • Price:$ 805.35
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  • Manufacture/Brand:Acints
  • Product Description:(S)-2-(6-Methoxy-naphthalen-2-yl)-propionylchloride 95%+
  • Packaging:1g
  • Price:$ 72.5
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  • Manufacture/Brand:Acints
  • Product Description:(S)-2-(6-Methoxy-naphthalen-2-yl)-propionylchloride 95%+
  • Packaging:10g
  • Price:$ 456.75
  • Delivery:In stock
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  • Manufacture/Brand:Acints
  • Product Description:(S)-2-(6-Methoxy-naphthalen-2-yl)-propionylchloride 95%+
  • Packaging:5g
  • Price:$ 253.75
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Relevant articles and documentsAll total 69 Articles be found

Non-carboxylic Analogues of Aryl Propionic Acid: Synthesis, Anti-inflammatory, Analgesic, Antipyretic and Ulcerogenic Potential

Eissa,Farrag,Galeel

, p. 485 - 492 (2014)

As a part of ongoing studies in developing new potent anti-inflammatory and analgesic agents, a series of novel 6-methoxy naphthalene derivatives was efficiently synthesized and characterized by spectral and elemental analyses. The newly synthesized compounds were evaluated for their anti-inflammatory activities using carrageenin-induced rat paw edema model, analgesic activities using acetic acid induced writhing model in mice and anti-pyretic activity using yeast induced hyperpyrexia method as well as ulcerogenic effects. Among the synthesized compounds, thiourea derivative (6a, e) exhibited higher anti-inflammatory activity than the standard drug naproxen in reduction of the rat paw edema (88.71, 89.77%) respectively. All of the non-carboxylic tested compounds were found to have promising anti-inflammatory, analgesic and antipyretic activity, while were devoid of any ulcerogenic effects.

Stereoselective fluorescence quenching by photoinduced electron transfer in naphthalene-amine dyads

Pischel, Uwe,Abad, Sergio,Miranda, Miguel A.

, p. 1088 - 1089 (2003)

Intramolecular chiral recognition in electron-transfer-induced fluorescence quenching has been observed for diastereomeric dyads composed of a naphthalene chromophore and an amine.

Chiral lewis acid-catalyzed highly enantioselective [4 + 3] cycloaddition reactions of nitrogen-stabilized oxyallyl cations derived from allenamides

Huang, Jian,Hsung, Richard P.

, p. 50 - 51 (2005)

A chiral Lewis acid-catalyzed highly enantioselective [4 + 3] cycloaddition reaction of allenamide-derived nitrogen-stabilized chiral oxyallyl cations is described here. The use of bisoxazoline ligand and CuOTf2 provides high enantioselectivity, especially with [SbF6]- as the counteranion. Copyright

Liquid chromatographic determination of cyclophosphamide enantiomers in plasma by precolumn chiral derivatization

Reid,Stobaugh,Sternson

, p. 441 - 446 (1989)

-

S-(+)-naproxen chloride as acylating agent for separating the enantiomers of chiral amines and alcohols

Spahn

, p. 847 - 850 (1988)

-

Synthesis and characterization of new types of 2-(6-methoxy-2-naphthyl) propionamide derivatives as potential antibacterial and antifungal agents

Helal, Mohamed H.,Abbas, Samir Y.,Salem, Mohamed A.,Farag, Awatef A.,Ammar, Yousry A.

, p. 5598 - 5609 (2013)

A series of novel 2-(6-methoxy-2-naphthyl)propionamide derivatives have been efficiently synthesized in excellent yields via the reaction of naproxenoyl chloride with different amino compounds. Most of the synthesized compounds were screened in vitro for

Esterase-activated release of naproxen from supramolecular nanofibres

Conda-Sheridan, Martin,Lee, Sungsoo S.,Preslar, Adam T.,Stupp, Samuel I.

, p. 13757 - 13760 (2014)

Nanofibre forming peptide amphiphiles were conjugated to naproxen through an esterase-sensitive linker. The amount of naproxen released, in the presence of enzymes, was influenced by the linker conjugating the drug to the supramolecular assembly. In vitro studies showed the anti-inflammatory activity of the released drug was maintained. This journal is

Radical Trifluoroacetylation of Alkenes Triggered by a Visible-Light-Promoted C–O Bond Fragmentation of Trifluoroacetic Anhydride

Zhang, Kun,Rombach, David,N?tel, Nicolas Yannick,Jeschke, Gunnar,Katayev, Dmitry

supporting information, p. 22487 - 22495 (2021/09/09)

We report a mild and operationally simple trifluoroacylation strategy of olefines, that utilizes trifluoroacetic anhydride as a low-cost and readily available reagent. This light-mediated process is fundamentally different from conventional methodologies and occurs through a trifluoroacyl radical mechanism promoted by a photocatalyst, which triggers a C?O bond fragmentation. Mechanistic studies (kinetic isotope effects, spectroelectrochemistry, optical spectroscopy, theoretical investigations) highlight the evidence of a fleeting CF3CO radical under photoredox conditions. The trifluoroacyl radical can be stabilized under CO atmosphere, delivering the trifluoroacetylation product with higher chemical efficiency. Furthermore, the method can be turned into a trifluoromethylation protocol by simply changing the reaction parameters. Beyond simple alkenes, this method allows for chemo- and regioselective functionalization of small-molecule drugs and common pharmacophores.

Practical and sustainable approach for clean preparation of 5-organylselanyl uracils

Chen, Jin-Yang,Zhong, Chun-Tao,Gui, Qing-Wen,Zhou, Yuan-Ming,Fang, Yang-Yang,Liu, Kai-Jian,Lin, Ying-Wu,Cao, Zhong,He, Wei-Min

supporting information, p. 475 - 479 (2020/10/12)

An eco-friendly, sustainable and practical method for the efficient preparation of 5-organylselanyl uracils through the electrochemical selenylation of uracils and diorganyl diselenides at room temperature under oxidant- and external electrolyte-free cond

Nickel/Photoredox-Catalyzed Methylation of (Hetero)aryl Chlorides Using Trimethyl Orthoformate as a Methyl Radical Source

Kariofillis, Stavros K.,Shields, Benjamin J.,Tekle-Smith, Makeda A.,Zacuto, Michael J.,Doyle, Abigail G.

supporting information, p. 7683 - 7689 (2020/04/22)

Methylation of organohalides represents a valuable transformation, but typically requires harsh reaction conditions or reagents. We report a radical approach for the methylation of (hetero)aryl chlorides using nickel/photoredox catalysis wherein trimethyl orthoformate, a common laboratory solvent, serves as a methyl source. This method permits methylation of (hetero)aryl chlorides and acyl chlorides at an early and late stage with broad functional group compatibility. Mechanistic investigations indicate that trimethyl orthoformate serves as a source of methyl radical via β-scission from a tertiary radical generated upon chlorine-mediated hydrogen atom transfer.

Visible-Light-Induced Radical Defluoroborylation of Trifluoromethyl Alkenes: An Access to gem-Difluoroallylboranes

Chen, Guojun,Wang, Liling,Liu, Xiaozu,Liu, Peijun

supporting information, p. 2990 - 2996 (2020/06/10)

A photoredox-catalyzed defluoroborylation of trifluoromethyl alkenes with N-heterocyclic carbene boranes is described for the synthesis of gem-difluoroallylboranes. This protocol exhibits a broad substrate scope and good functional group compatibility, which enables the late-stage functionalization of structurally complex compounds. Further transformations of the defluoroborylation products to valuable CF2-containing molecules are also demonstrated. (Figure presented.).

Synthesis, comparative docking, and pharmacological activity of naproxen amino acid derivatives as possible anti-inflammatory and analgesic agents

Elhenawy, Ahmed A.,Al-Harbi,Moustafa, Gaber O.,El-Gazzar,Abdel-Rahman, Rehab F.,Salim, Abd Elhamid

, p. 1773 - 1790 (2019/06/28)

Background and aim: Naproxen is a member of the Nonsteroidal anti-inflammatory drugs (NSAIDs). This work aimed to synthesize a safe NSAID agent based on a peptide derivative. Methods: The structure of compounds 5–20 was established on the basis of spectral data. Frontier molecular orbitals and chemical reactivity were discussed to clarify inter-and intramolecular interactions among tested compounds. We applied competitive molecular docking using polynomial logarithms to identify the most accurate algorithm for pharmacological activity prediction for the tested compounds. The docking protocol with the lowest RMSD was selected for analyzing binding affinity. Results: Docking results illustrated that the binding interaction increased after introduction of an acidic fragment to the parent compound. These compounds were selected for additional study against adsorption, distribution, metabolism, excretion, and toxicity (ADMET) in silico. The compounds tested had good oral bioavailability without any carcinogenesis effect; no marked health effects were observed via rodent toxicity. Compounds passed through docking and ADMET profiles for them (5–16) were examined as anti-inflammatory and analgesic agents. Compounds 8 and 16 showed higher anti-inflammatory potency than the reference drug and tested compounds. Compounds 8, 10, and 14 exhibited the highest analgesic potency compared to the other tested compounds. Conclusion: The tested compounds have shown negligible ulcerogenic effects, and may be considered safer drugs than naproxen for treating inflammatory conditions.

Process route upstream and downstream products

Process route

(2S)-2-(6-methoxy(2-naphthyl))propanoic acid
22204-53-1

(2S)-2-(6-methoxy(2-naphthyl))propanoic acid

(S)-naproxenoyl chloride
51091-84-0

(S)-naproxenoyl chloride

Conditions
Conditions Yield
With thionyl chloride; N,N-dimethyl-formamide; In dichloromethane; at 20 ℃; for 1h; Glovebox; Inert atmosphere;
100%
With oxalyl dichloride; N,N-dimethyl-formamide; In dichloromethane; at 0 - 25 ℃;
97%
With oxalyl dichloride; N,N-dimethyl-formamide; In dichloromethane; at 0 - 20 ℃; for 12h; Inert atmosphere;
96%
With thionyl chloride; In dichloromethane; for 3h;
95%
With phosgene; N-formyldiethylamine; In dichloromethane; at 20 - 25 ℃; for 1.83333h; Product distribution / selectivity;
94%
With dmap; thionyl chloride; In benzene; for 3h; Reflux;
91%
With thionyl chloride; N,N-dimethyl-formamide; In chloroform; 1.) reflux, 2 h, 2.) r.t., 18 h;
89%
With thionyl chloride; triethylamine; In cyclohexane; at 60 ℃; for 2h;
89%
With thionyl chloride; N,N-dimethyl-formamide; In chloroform; for 3h; Heating / reflux;
88.8%
With trichlorophosphate; In m-xylene; for 3h; Reagent/catalyst; Reflux;
75%
With oxalyl dichloride; In toluene; at 90 ℃; for 4h;
53%
With thionyl chloride; In toluene; for 1h; Heating;
With oxalyl dichloride; N,N-dimethyl-formamide; In benzene; at 45 ℃; for 1h;
With thionyl chloride; In benzene; for 1.5h; Heating;
With oxallyl chloride; N,N-dimethyl-formamide; In dichloromethane;
With thionyl chloride; In chloroform; Heating;
With oxalyl dichloride; In dichloromethane; at 0 - 20 ℃; for 3.5h;
With oxalyl dichloride;
With thionyl chloride; In toluene; for 3h; Heating;
With thionyl chloride; In benzene; Heating;
With thionyl chloride; In benzene; a) reflux, 30 min, b) 20 deg C, 12 h;
With oxalyl dichloride; N,N-dimethyl-formamide; In dichloromethane; for 8h; Ambient temperature;
With oxalyl dichloride; In N,N-dimethyl-formamide; benzene; for 1h; Ambient temperature;
With oxalyl dichloride; at 20 ℃; for 1h;
With thionyl chloride;
With thionyl chloride; In toluene; at 80 ℃; for 2h;
With oxalyl dichloride; N,N-dimethyl-formamide; In chloroform; at 0 - 20 ℃; for 1.5h;
With thionyl chloride; In dichloromethane; for 2h; Heating;
With oxalyl dichloride; at 20 ℃; for 1h;
With oxalyl dichloride; N,N-dimethyl-formamide; In dichloromethane; at 20 ℃; for 1h; Inert atmosphere;
With thionyl chloride; at 80 ℃; for 1h;
With oxalyl dichloride; N,N-dimethyl-formamide; In dichloromethane; at 20 ℃; for 3.16h; Inert atmosphere;
With oxalyl dichloride; for 0.5h;
With thionyl chloride; In benzene; for 3h; Reflux;
With oxalyl dichloride; N,N-dimethyl-formamide; In dichloromethane; for 1.5h; Cooling with ice;
With oxalyl dichloride; In dichloromethane; at 0 - 20 ℃;
With oxalyl dichloride; In dichloromethane; N,N-dimethyl-formamide; at 25 ℃; for 12h;
With oxalyl dichloride; In hexane; for 2h; Reflux; Inert atmosphere;
With oxalyl dichloride; N,N-dimethyl-formamide; In 1,2-dichloro-ethane; for 1h; Reflux;
With oxalyl dichloride;
With thionyl chloride; triethylamine; In toluene; at 40 ℃; for 4h;
In dichloromethane; N,N-dimethyl-formamide; at 0 ℃; Reflux;
With thionyl chloride; In benzene; for 2h; Inert atmosphere; Reflux;
With oxalyl dichloride; In dichloromethane; N,N-dimethyl-formamide; at 0 ℃; for 3h;
With oxalyl dichloride; N,N-dimethyl-formamide; In dichloromethane; at 0 - 20 ℃; for 2.5h; Inert atmosphere;
With thionyl chloride; at 85 ℃; for 3h;
With thionyl chloride; In dichloromethane; N,N-dimethyl-formamide; at 20 ℃; for 3h; Inert atmosphere;
With thionyl chloride; In benzene; Reflux;
With oxalyl dichloride; In hexane; for 2h; enantioselective reaction; Reflux; Inert atmosphere;
With oxalyl dichloride; In dichloromethane; N,N-dimethyl-formamide; at 0 - 20 ℃; for 2.5h; Inert atmosphere;
With oxalyl dichloride; In dichloromethane; at 25 ℃;
With bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; In dichloromethane;
With thionyl chloride; In toluene; at 110 ℃; for 5h;
With thionyl chloride; In dichloromethane; Reflux;
With thionyl chloride; In dichloromethane; for 5h; Heating / reflux;
With thionyl chloride; Heating;
With oxalyl dichloride; N,N-dimethyl-formamide; In dichloromethane; at 20 ℃; for 5h;
With oxalyl dichloride; In dichloromethane; N,N-dimethyl-formamide; at 20 ℃; for 1h;
With oxalyl dichloride; In benzene; at 20 ℃; for 6h;
With thionyl chloride; N,N-dimethyl-formamide; for 3h; Reflux;
(+)-2-(6-methoxy-2-naphthyl)propionic acid
22204-53-1,23979-41-1,23981-80-8,26159-31-9

(+)-2-(6-methoxy-2-naphthyl)propionic acid

Conditions
Conditions Yield
With oxalyl dichloride; for 0.5h; Ambient temperature;
100%
With oxalyl dichloride; In benzene; Ambient temperature;
oxalyl dichloride
79-37-8

oxalyl dichloride

(2S)-2-(6-methoxy(2-naphthyl))propanoic acid
22204-53-1

(2S)-2-(6-methoxy(2-naphthyl))propanoic acid

(S)-naproxenoyl chloride
51091-84-0

(S)-naproxenoyl chloride

Conditions
Conditions Yield
In tetrahydrofuran; N,N-dimethyl-formamide;
S-2-(6-methoxy-2-naphthyl)propionaldehyde
32305-59-2

S-2-(6-methoxy-2-naphthyl)propionaldehyde

(S)-naproxenoyl chloride
51091-84-0

(S)-naproxenoyl chloride

Conditions
Conditions Yield
With oxalyl dichloride; In hexane;
Naprelan
26159-34-2

Naprelan

(S)-naproxenoyl chloride
51091-84-0

(S)-naproxenoyl chloride

Conditions
Conditions Yield
Multi-step reaction with 2 steps
1: sulfuric acid / ethanol
2: thionyl chloride / Heating
With thionyl chloride; sulfuric acid; In ethanol;
thionyl chloride
7719-09-7

thionyl chloride

(2S)-2-(6-methoxy(2-naphthyl))propanoic acid
22204-53-1

(2S)-2-(6-methoxy(2-naphthyl))propanoic acid

(S)-naproxenoyl chloride
51091-84-0

(S)-naproxenoyl chloride

Conditions
Conditions Yield
(S)-naproxenoyl chloride
51091-84-0

(S)-naproxenoyl chloride

Conditions
Conditions Yield
With oxalyl dichloride; N,N-dimethyl-formamide; In dichloromethane; at 20 ℃; for 3h; Inert atmosphere;
(2S)-2-(6-methoxy(2-naphthyl))propanoic acid
22204-53-1

(2S)-2-(6-methoxy(2-naphthyl))propanoic acid

(S)-naproxenoyl chloride
51091-84-0

(S)-naproxenoyl chloride

Conditions
Conditions Yield
With thionyl chloride; N,N-dimethyl-formamide; In dichloromethane; at 20 ℃; for 1h; Glovebox; Inert atmosphere;
100%
With oxalyl dichloride; N,N-dimethyl-formamide; In dichloromethane; at 0 - 25 ℃;
97%
With oxalyl dichloride; N,N-dimethyl-formamide; In dichloromethane; at 0 - 20 ℃; for 12h; Inert atmosphere;
96%
With thionyl chloride; In dichloromethane; for 3h;
95%
With phosgene; N-formyldiethylamine; In dichloromethane; at 20 - 25 ℃; for 1.83333h; Product distribution / selectivity;
94%
With dmap; thionyl chloride; In benzene; for 3h; Reflux;
91%
With thionyl chloride; N,N-dimethyl-formamide; In chloroform; 1.) reflux, 2 h, 2.) r.t., 18 h;
89%
With thionyl chloride; triethylamine; In cyclohexane; at 60 ℃; for 2h;
89%
With thionyl chloride; N,N-dimethyl-formamide; In chloroform; for 3h; Heating / reflux;
88.8%
With trichlorophosphate; In m-xylene; for 3h; Reagent/catalyst; Reflux;
75%
With oxalyl dichloride; In toluene; at 90 ℃; for 4h;
53%
With thionyl chloride; In toluene; for 1h; Heating;
With oxalyl dichloride; N,N-dimethyl-formamide; In benzene; at 45 ℃; for 1h;
With thionyl chloride; In benzene; for 1.5h; Heating;
With oxallyl chloride; N,N-dimethyl-formamide; In dichloromethane;
With thionyl chloride; In chloroform; Heating;
With oxalyl dichloride; In dichloromethane; at 0 - 20 ℃; for 3.5h;
With oxalyl dichloride;
With thionyl chloride; In toluene; for 3h; Heating;
With thionyl chloride; In benzene; Heating;
With thionyl chloride; In benzene; a) reflux, 30 min, b) 20 deg C, 12 h;
With oxalyl dichloride; N,N-dimethyl-formamide; In dichloromethane; for 8h; Ambient temperature;
With oxalyl dichloride; In N,N-dimethyl-formamide; benzene; for 1h; Ambient temperature;
With oxalyl dichloride; at 20 ℃; for 1h;
With thionyl chloride;
With thionyl chloride; In toluene; at 80 ℃; for 2h;
With oxalyl dichloride; N,N-dimethyl-formamide; In chloroform; at 0 - 20 ℃; for 1.5h;
With thionyl chloride; In dichloromethane; for 2h; Heating;
With oxalyl dichloride; at 20 ℃; for 1h;
With oxalyl dichloride; N,N-dimethyl-formamide; In dichloromethane; at 20 ℃; for 1h; Inert atmosphere;
With thionyl chloride; at 80 ℃; for 1h;
With oxalyl dichloride; N,N-dimethyl-formamide; In dichloromethane; at 20 ℃; for 3.16h; Inert atmosphere;
With oxalyl dichloride; for 0.5h;
With thionyl chloride; In benzene; for 3h; Reflux;
With oxalyl dichloride; N,N-dimethyl-formamide; In dichloromethane; for 1.5h; Cooling with ice;
With oxalyl dichloride; In dichloromethane; at 0 - 20 ℃;
With oxalyl dichloride; In dichloromethane; N,N-dimethyl-formamide; at 25 ℃; for 12h;
With oxalyl dichloride; In hexane; for 2h; Reflux; Inert atmosphere;
With oxalyl dichloride; N,N-dimethyl-formamide; In 1,2-dichloro-ethane; for 1h; Reflux;
With oxalyl dichloride;
With thionyl chloride; triethylamine; In toluene; at 40 ℃; for 4h;
In dichloromethane; N,N-dimethyl-formamide; at 0 ℃; Reflux;
With thionyl chloride; In benzene; for 2h; Inert atmosphere; Reflux;
With oxalyl dichloride; In dichloromethane; N,N-dimethyl-formamide; at 0 ℃; for 3h;
With oxalyl dichloride; N,N-dimethyl-formamide; In dichloromethane; at 0 - 20 ℃; for 2.5h; Inert atmosphere;
With thionyl chloride; at 85 ℃; for 3h;
With thionyl chloride; In dichloromethane; N,N-dimethyl-formamide; at 20 ℃; for 3h; Inert atmosphere;
With thionyl chloride; In benzene; Reflux;
With oxalyl dichloride; In hexane; for 2h; enantioselective reaction; Reflux; Inert atmosphere;
With oxalyl dichloride; In dichloromethane; N,N-dimethyl-formamide; at 0 - 20 ℃; for 2.5h; Inert atmosphere;
With oxalyl dichloride; In dichloromethane; at 25 ℃;
With bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; In dichloromethane;
With thionyl chloride; In toluene; at 110 ℃; for 5h;
With thionyl chloride; In dichloromethane; Reflux;
With thionyl chloride; In dichloromethane; for 5h; Heating / reflux;
With thionyl chloride; Heating;
With oxalyl dichloride; N,N-dimethyl-formamide; In dichloromethane; at 20 ℃; for 5h;
With oxalyl dichloride; In dichloromethane; N,N-dimethyl-formamide; at 20 ℃; for 1h;
With oxalyl dichloride; In benzene; at 20 ℃; for 6h;
With thionyl chloride; N,N-dimethyl-formamide; for 3h; Reflux;
(+)-2-(6-methoxy-2-naphthyl)propionic acid
22204-53-1,23979-41-1,23981-80-8,26159-31-9

(+)-2-(6-methoxy-2-naphthyl)propionic acid

Conditions
Conditions Yield
With oxalyl dichloride; for 0.5h; Ambient temperature;
100%
With oxalyl dichloride; In benzene; Ambient temperature;
oxalyl dichloride
79-37-8

oxalyl dichloride

(2S)-2-(6-methoxy(2-naphthyl))propanoic acid
22204-53-1

(2S)-2-(6-methoxy(2-naphthyl))propanoic acid

(S)-naproxenoyl chloride
51091-84-0

(S)-naproxenoyl chloride

Conditions
Conditions Yield
In tetrahydrofuran; N,N-dimethyl-formamide;

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  • Sigma-Aldrich Chemie GmbH
  • Business Type:Trading Company
  • Contact Tel:800 558-9160
  • Emails:romesh.collins@milliporesigma.com
  • Main Products:1
  • Country:Germany
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