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51436-99-8

51436-99-8

Identification

Synonyms:4-bromo-2-fluoro-1-methyl-benzene;2-fluoro-4-bromotoluene;2-Bromo-2-fluorotoluene;

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Safety information and MSDS view more

  • Pictogram(s):HarmfulXn

  • Hazard Codes:Xn,Xi

  • Signal Word:Warning

  • Hazard Statement:H302 Harmful if swallowedH315 Causes skin irritation H319 Causes serious eye irritation H335 May cause respiratory irritation

  • First-aid measures: General adviceConsult a physician. Show this safety data sheet to the doctor in attendance.If inhaled If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician. In case of skin contact Wash off with soap and plenty of water. Consult a physician. In case of eye contact Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician. If swallowed Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.

  • Fire-fighting measures: Suitable extinguishing media Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide. Wear self-contained breathing apparatus for firefighting if necessary.

  • Accidental release measures: Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. For personal protection see section 8. Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided. Pick up and arrange disposal. Sweep up and shovel. Keep in suitable, closed containers for disposal.

  • Handling and storage: Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Avoid exposure - obtain special instructions before use.Provide appropriate exhaust ventilation at places where dust is formed. For precautions see section 2.2. Store in cool place. Keep container tightly closed in a dry and well-ventilated place.

  • Exposure controls/personal protection:Occupational Exposure limit valuesBiological limit values Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday. Eye/face protection Safety glasses with side-shields conforming to EN166. Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU). Skin protection Wear impervious clothing. The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace. Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique(without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it. Respiratory protection Wear dust mask when handling large quantities. Thermal hazards

Supplier and reference price view more

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  • Manufacture/Brand:TRC
  • Product Description:4-Bromo-2-fluorotoluene
  • Packaging:5g
  • Price:$ 75
  • Delivery:In stock
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  • Manufacture/Brand:TCI Chemical
  • Product Description:4-Bromo-2-fluorotoluene >97.0%(GC)
  • Packaging:25g
  • Price:$ 68
  • Delivery:In stock
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  • Manufacture/Brand:TCI Chemical
  • Product Description:4-Bromo-2-fluorotoluene >97.0%(GC)
  • Packaging:5g
  • Price:$ 24
  • Delivery:In stock
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  • Manufacture/Brand:SynQuest Laboratories
  • Product Description:4-Bromo-2-fluorotoluene 99%
  • Packaging:2.5 kg
  • Price:$ 495
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  • Manufacture/Brand:SynQuest Laboratories
  • Product Description:4-Bromo-2-fluorotoluene 99%
  • Packaging:500 g
  • Price:$ 135
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  • Manufacture/Brand:SynQuest Laboratories
  • Product Description:4-Bromo-2-fluorotoluene 99%
  • Packaging:25 g
  • Price:$ 10
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  • Manufacture/Brand:SynQuest Laboratories
  • Product Description:4-Bromo-2-fluorotoluene 99%
  • Packaging:100 g
  • Price:$ 35
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  • Manufacture/Brand:Sigma-Aldrich
  • Product Description:4-Bromo-2-fluorotoluene 99%
  • Packaging:5g
  • Price:$ 34.6
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  • Manufacture/Brand:Matrix Scientific
  • Product Description:4-Bromo-2-fluorotoluene 99%
  • Packaging:25g
  • Price:$ 15
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  • Manufacture/Brand:Matrix Scientific
  • Product Description:4-Bromo-2-fluorotoluene 99%
  • Packaging:250g
  • Price:$ 85
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Relevant articles and documentsAll total 2 Articles be found

Syntheses of 4-methoxymethylbenzyl permethrinates containing fluorine and their insecticidal activity

Zou, Xinzhuo,Qiu, Zongxing

, p. 173 - 179 (2007/10/03)

In order to investigate the relationship between the position of fluorine atom and insecticidal activity about 4-methoxymethylbenzyl permethrinates containing fluorine, 2 and 3-fluoro-4-methoxymethylbenzyl (±)-cis-permethrinate were synthesized. Their insecticidal activities were tested and the fluorine effect of title compounds was discussed.

Process route upstream and downstream products

Process route

5-bromo-2-methylaniline
39478-78-9

5-bromo-2-methylaniline

2-fluoro-4-bromotoluene
51436-99-8

2-fluoro-4-bromotoluene

Conditions
Conditions Yield
5-bromo-2-methylaniline; With hydrogenchloride; sodium tetrafluoroborate; sodium nitrite;
Heating;
67.6%
4-bromo-2-nitrotoluene
60956-26-5

4-bromo-2-nitrotoluene

2-fluoro-4-bromotoluene
51436-99-8

2-fluoro-4-bromotoluene

Conditions
Conditions Yield
Multi-step reaction with 2 steps
1.1: 84.5 percent / Fe; CH3COOH
2.1: HCl; NaBF4; NaNO2
2.2: 67.6 percent / Heating
With hydrogenchloride; sodium tetrafluoroborate; iron; acetic acid; sodium nitrite; 2.2: Schiemann reaction;
4-Methyl-3-nitroanilin
119-32-4

4-Methyl-3-nitroanilin

2-fluoro-4-bromotoluene
51436-99-8

2-fluoro-4-bromotoluene

Conditions
Conditions Yield
Multi-step reaction with 3 steps
1.1: H2SO4; NaNO2
1.2: 57.5 percent / CuBr
2.1: 84.5 percent / Fe; CH3COOH
3.1: HCl; NaBF4; NaNO2
3.2: 67.6 percent / Heating
With hydrogenchloride; sodium tetrafluoroborate; sulfuric acid; iron; acetic acid; sodium nitrite; 1.2: Sandmeyer reaction / 3.2: Schiemann reaction;
2-fluoro-4-bromotoluene
51436-99-8

2-fluoro-4-bromotoluene

Conditions
Conditions Yield
conc sulphuric acid

conc sulphuric acid

2-fluoro-4-bromotoluene
51436-99-8

2-fluoro-4-bromotoluene

sulfuric acid
7664-93-9

sulfuric acid

4-bromo-2-fluorobenzaldehyde
57848-46-1

4-bromo-2-fluorobenzaldehyde

Conditions
Conditions Yield
With acetic anhydride; In ethanol; water; acetic acid;
2-fluoro-4-bromotoluene
51436-99-8

2-fluoro-4-bromotoluene

carbon dioxide
124-38-9,18923-20-1

carbon dioxide

3-fluoro-4-methyl-benzoic acid
350-28-7

3-fluoro-4-methyl-benzoic acid

Conditions
Conditions Yield
carbon dioxide; With o-phenylenebis(diphenylphosphine); copper(II) acetate monohydrate; In 1,4-dioxane; at 65 ℃; for 0.333333h; Schlenk technique;
2-fluoro-4-bromotoluene; With palladium diacetate; triethylamine; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,4-dioxane; toluene; at 100 ℃; for 4h; Schlenk technique; Sealed tube;
84%
carbon dioxide; With o-phenylenebis(diphenylphosphine); copper(II) acetate monohydrate; In 1,4-dioxane; at 60 ℃; for 0.416667h; Schlenk technique;
2-fluoro-4-bromotoluene; With palladium diacetate; triethylamine; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,4-dioxane; toluene; at 100 ℃; for 4h; Schlenk technique;
84%
2-fluoro-4-bromotoluene; With magnesium; In tetrahydrofuran;
carbon dioxide;
71.3%
2-fluoro-4-bromotoluene
51436-99-8

2-fluoro-4-bromotoluene

2-fluoro-4-bromobenzoic acid
112704-79-7

2-fluoro-4-bromobenzoic acid

Conditions
Conditions Yield
With 2,2'-azobis(isobutyronitrile); oxygen; sodium bromide; cobalt(II) acetate; acetic acid; In various solvent(s); at 110 ℃; for 4.5h; under 760.051 Torr;
91%
With 2,2'-azobis(isobutyronitrile); oxygen; cobalt(II) diacetate tetrahydrate; acetic acid; sodium bromide; at 130 ℃; for 1.5h; under 9000.9 Torr; Green chemistry;
88%
2-fluoro-4-bromotoluene
51436-99-8

2-fluoro-4-bromotoluene

4-bromo-2-fluorobenzyl bromide
76283-09-5

4-bromo-2-fluorobenzyl bromide

Conditions
Conditions Yield
With N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); In tetrachloromethane; at 100 ℃; for 13h;
89%
With N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); In tetrachloromethane; at 100 ℃; for 13h;
89%
With N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); In tetrachloromethane; for 4h; Reflux; Inert atmosphere;
53%
With N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); In tetrachloromethane; for 4h; Heating;
With N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); In tetrachloromethane;
With N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); In tetrachloromethane; for 2h; Heating;
With N-Bromosuccinimide; 2-(4-biphenylyl)-5-phenyloxazole; In tetrachloromethane; at 80 ℃; for 15h; Inert atmosphere;
With N-Bromosuccinimide; dibenzoyl peroxide; In acetonitrile; at 80 ℃; Inert atmosphere;
2-fluoro-4-bromotoluene
51436-99-8

2-fluoro-4-bromotoluene

4-bromo-benzaldehyde
1122-91-4

4-bromo-benzaldehyde

1-(4-bromo-phenyl)-1-(3-fluoro-4-methylphenyl)-methanol
853348-88-6

1-(4-bromo-phenyl)-1-(3-fluoro-4-methylphenyl)-methanol

Conditions
Conditions Yield
2-fluoro-4-bromotoluene; With magnesium; iodine; In tetrahydrofuran; for 1.66667h; Heating / reflux;
4-bromo-benzaldehyde; In tetrahydrofuran; at 0 - 20 ℃; for 2.5h;
65%
2-fluoro-4-bromotoluene
51436-99-8

2-fluoro-4-bromotoluene

2-cyclopropyl-N-methoxy-N-methyl-acetamide
227322-00-1

2-cyclopropyl-N-methoxy-N-methyl-acetamide

2-cyclopropyl-1-(3-fluoro-4-methylphenyl)ethan-1-one

2-cyclopropyl-1-(3-fluoro-4-methylphenyl)ethan-1-one

Conditions
Conditions Yield
2-fluoro-4-bromotoluene; With diisobutylaluminium hydride; magnesium; In tetrahydrofuran; n-heptane; at 30 - 50 ℃; for 4.5h; Large scale;
2-cyclopropyl-N-methoxy-N-methyl-acetamide; In tetrahydrofuran; n-heptane; at 15 - 25 ℃; for 2h; Large scale;
91.3%
2-fluoro-4-bromotoluene; With diisobutylaluminium hydride; magnesium; In tetrahydrofuran; n-heptane; at 30 - 50 ℃; for 4.5h; Large scale;
2-cyclopropyl-N-methoxy-N-methyl-acetamide; In tetrahydrofuran; n-heptane; at 15 - 25 ℃; for 2h; Large scale;
91.3%
2-fluoro-4-bromotoluene; With diisobutylaluminium hydride; magnesium; In tetrahydrofuran; n-heptane; at 30 - 50 ℃; Large scale;
2-cyclopropyl-N-methoxy-N-methyl-acetamide; In tetrahydrofuran; n-heptane; at 15 - 25 ℃; for 2h; Large scale;
150.7 kg

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