51579-82-9 Usage
Originator
Amfenac sodium,Yungjin Pharmacetical
Co. Ltd.
Uses
Anti-inflammatory.
Definition
ChEBI: An oxo monocarboxylic acid that is benzophenone in which one of the phenyl groups is substituted by an amino group and a carboxymethyl group at position 2 and 3, respectively. The corresponding carboxamide, nepafenac, is a prodrug of amfenac and is used fo
the treatment of pain and inflammation following cataract surgery.
Manufacturing Process
7-Benzoylindolin-2-one:
Method A. A mixture of 2.5 g (0.0077 mole) of ethyl 2-acetamido-3-
benzoylphenylacetate in 50 ml of 3 N hydrochloric acid was refluxed for one
hour. The reaction mixture was filtered and the filtrate was poured into a
mixture of ice and water. The precipitate was collected and recrystallized from
acetone; yield of 7-benzoylindolin-2-one 1 g (55%); melting point 154°C.
Method B. A solution of 1.3 g (0.0044 mole) of 2-acetamido-3-
benzoylphenylacetic acid in 15 ml of 3 N hydrochloric acid and 15 ml of acetic
acid was refluxed for three hours. The cooled solution was poured into ice
water and the 7-benzoylindolin-2-one which precipitated was collected and
dried.
2-Amino-3-benzoylphenylacetic acid:
A mixture of 1.0 g (0.004 mole) of 7-benzoylindolin-2-one was added to 30
ml of 3 N sodium hydroxide and the basic solution was refluxed for 45 min
under nitrogen. The mixture was filtered and the filtrate was neutralized with
glacial acetic acid. The precipitate was filtered off, washed with water and
dried. The 2-amino-3-benzoylbenzeneacetic acid melted at 122°C (dec.). The
yield was 0.8 g (72%).
Therapeutic Function
Antiinflammatory
Check Digit Verification of cas no
The CAS Registry Mumber 51579-82-9 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,1,5,7 and 9 respectively; the second part has 2 digits, 8 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 51579-82:
(7*5)+(6*1)+(5*5)+(4*7)+(3*9)+(2*8)+(1*2)=139
139 % 10 = 9
So 51579-82-9 is a valid CAS Registry Number.
InChI:InChI=1/C15H13NO3/c16-14-11(9-13(17)18)7-4-8-12(14)15(19)10-5-2-1-3-6-10/h1-8H,9,16H2,(H,17,18)
51579-82-9Relevant articles and documents
EXTERNAL PREPARATION CONTAINING ANALGESIC/ANTI-INFLAMMATORY AGENT
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, (2012/01/14)
An external preparation containing the following components (A), (B), (C), and (D): (A) a non-steroidal analgesic/anti-inflammatory agent,(B) a terpene and/or an essential oil containing a terpene,(C) a higher alcohol, and(D) a polyoxyalkylene alkyl ether
