5162-90-3

Basic information

• Product Name: 2-Amino-3-(1,2-dihydro-2-oxoquinoline-4-yl)propanoic acid
• Synonyms: 2-AMino-3-(2-oxo-1,2-dihydroquinolin-4-yl)propanoic acid;2-AMino-3-(1,2-dihydro-2-oxoquinoline-4-yl);2-AMino -3-[2(1H)-quinolinon-4-yl]-Propinonic acid;2-Amino-3-(1,2-dihydro-2-oxoquinolin-4-yl)propanoic acid;3-(1,2-Dihydro-2-oxoquinolin-4-yl)-DL-alanine, 2-Amino-3-(1,2-dihydro-2-oxoquinolin-4-yl)propionic acid;Rebamipide Impurity 3;3-(2-Oxo-1,2-dihydro-4-quinolinyl)alanine ;2-Amino -3-[2(1H)-quinolinon-4-yl]-Propinonic
• CAS NO: 5162-90-3
• Molecular Formula: C₁₂H₁₂N₂O₃
• Molecular Weight: 232.24
• Product Categories: Organic acids;API intermediates;(intermediate of rebamipide)
• Mol File: 5162-90-3.mol

Chemical Properties

• Melting Point: 290°C (dec.)
• Boiling Point: 420.7 °C at 760 mmHg
• Flash Point: 208.2 °C
• Appearance: white or almost white crystalline powder
• Density: 1.343
• Vapor Pressure: 2.76E-07mmHg at 25°C
• Refractive Index: 1.562
• Solubility: DMSO (Slightly), Methanol (Slightly)
• PKA: 2.22±0.10(Predicted)
• CAS DataBase Reference: 2-Amino-3-(1,2-dihydro-2-oxoquinoline-4-yl)propanoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Amino-3-(1,2-dihydro-2-oxoquinoline-4-yl)propanoic acid(5162-90-3)
• EPA Substance Registry System: 2-Amino-3-(1,2-dihydro-2-oxoquinoline-4-yl)propanoic acid(5162-90-3)

Safety Data

• Hazard Codes: Xn
• Statements: 22
• Safety Statements: 26
• Hazardous Substances Data: 5162-90-3(Hazardous Substances Data)

Usage

Uses

Used in Antimicrobial Applications:
2-Amino-3-(1,2-dihydro-2-oxoquinoline-4-yl)propanoic acid is used as a predictive tool for assessing the activity of antimicrobial peptides. Its unique structure allows it to provide valuable insights into the topological information of amino acids, which is crucial for understanding the mechanisms of action and potential effectiveness of these peptides in combating various pathogens.
Used in Pharmaceutical Research:
In the pharmaceutical industry, 2-Amino-3-(1,2-dihydro-2-oxoquinoline-4-yl)propanoic acid can be utilized as a key component in the development of new drugs targeting various diseases. Its ability to interact with other molecules and its unique chemical properties make it a promising candidate for drug design and optimization.
Used in Chemical Synthesis:
2-Amino-3-(1,2-dihydro-2-oxoquinoline-4-yl)propanoic acid can also be employed as a building block or intermediate in the synthesis of more complex organic compounds. Its versatile structure and reactivity can be harnessed to create novel molecules with specific properties and applications in various fields, including materials science, agrochemistry, and environmental science.

InChI:InChI:1S/C12H12N2O3/c13-9(12(16)17)5-7-6-11(15)14-10-4-2-1-3-8(7)10/h1-4,6,9H,5,13H2,(H,14,15)(H,16,17)

Upstream product

• 4900-38-3 2-acetylamino-2-(ethoxycarbonyl)-3-(2-oxo-1,2-dihydroquinolin-4-yl)propionic acid ethyl ester 
• 59-31-4 2-quinolone 
• 617-45-8 aspartic Acid 

Downstream Products

• 90098-04-7 rebamipide 

Relevant articles and documents

Novel synthetic method for rebamipide intermediate

The invention discloses a novel synthetic method for a rebamipide intermediate, i.e., 2-amino-3-[2(1H)-quinolone-4]propionic acid. The method comprises a step of reacting aspartic acid with 2-hydroxyquinoline to prepare the key rebamipide intermediate, i.e., 2-amino-3-[2(1H)-quinolone-4]propionic acid; and the key rebamipide intermediate and p-chlorobenzoyl chloride undergo a condensation reactionso as to prepare rebamipide. The synthetic method for the intermediate has the advantages of low cost and easy availability of raw materials, short reaction steps and good optical purity.

PROCESS FOR PRODUCTION OF CARBOSTYRIL COMPOUND

Disclosed is an improved process which can produce a carbostyril compound of the formula (1) or a salt thereof, which is useful as a pharmaceutical agent, more safely with higher efficiency. An improved process for producing a carbostyril compound comprising the steps of adding a high boiling solvent to a compound of the formula (4) and refluxing the resulting mixture under heating in hydrochloric acid to produce a compound of the formula (5) safely and acylating the compound of the formula (5) to produce a carbostyril compound of the formula (1).