5162-90-3

Basic information

• Product Name: 2-Amino-3-(1,2-dihydro-2-oxoquinoline-4-yl)propanoic acid
• Synonyms: 2-AMino-3-(2-oxo-1,2-dihydroquinolin-4-yl)propanoic acid;2-AMino-3-(1,2-dihydro-2-oxoquinoline-4-yl);2-AMino -3-[2(1H)-quinolinon-4-yl]-Propinonic acid;2-Amino-3-(1,2-dihydro-2-oxoquinolin-4-yl)propanoic acid;3-(1,2-Dihydro-2-oxoquinolin-4-yl)-DL-alanine, 2-Amino-3-(1,2-dihydro-2-oxoquinolin-4-yl)propionic acid;Rebamipide Impurity 3;3-(2-Oxo-1,2-dihydro-4-quinolinyl)alanine ;2-Amino -3-[2(1H)-quinolinon-4-yl]-Propinonic
• CAS NO: 5162-90-3
• Molecular Formula: C₁₂H₁₂N₂O₃
• Molecular Weight: 232.24
• Product Categories: Organic acids;API intermediates;(intermediate of rebamipide)
• Mol File: 5162-90-3.mol
• Article Data: 2

Chemical Properties

• Melting Point: 290°C (dec.)
• Boiling Point: 420.7 °C at 760 mmHg
• Flash Point: 208.2 °C
• Appearance: white or almost white crystalline powder
• Density: 1.343
• Vapor Pressure: 2.76E-07mmHg at 25°C
• Refractive Index: 1.562
• Solubility: DMSO (Slightly), Methanol (Slightly)
• PKA: 2.22±0.10(Predicted)
• CAS DataBase Reference: 2-Amino-3-(1,2-dihydro-2-oxoquinoline-4-yl)propanoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Amino-3-(1,2-dihydro-2-oxoquinoline-4-yl)propanoic acid(5162-90-3)
• EPA Substance Registry System: 2-Amino-3-(1,2-dihydro-2-oxoquinoline-4-yl)propanoic acid(5162-90-3)

Safety Data

• Hazard Codes: Xn
• Statements: 22
• Safety Statements: 26
• Hazardous Substances Data: 5162-90-3(Hazardous Substances Data)

Usage

Uses

α-Amino-β-[4-(1,2-dihydro-2-oxoquinoline)]propionic Acid can be used to predict the activity of antimicrobial peptides with amino acid topological information.

InChI:InChI:1S/C12H12N2O3/c13-9(12(16)17)5-7-6-11(15)14-10-4-2-1-3-8(7)10/h1-4,6,9H,5,13H2,(H,14,15)(H,16,17)

Upstream product

• 59-31-4 2-quinolone 
• 617-45-8 aspartic Acid 
• 4900-38-3 2-acetylamino-2-(ethoxycarbonyl)-3-(2-oxo-1,2-dihydroquinolin-4-yl)propionic acid ethyl ester 

Downstream Products

• 90098-04-7 rebamipide 

Relevant articles and documents

Novel synthetic method for rebamipide intermediate

The invention discloses a novel synthetic method for a rebamipide intermediate, i.e., 2-amino-3-[2(1H)-quinolone-4]propionic acid. The method comprises a step of reacting aspartic acid with 2-hydroxyquinoline to prepare the key rebamipide intermediate, i.e., 2-amino-3-[2(1H)-quinolone-4]propionic acid; and the key rebamipide intermediate and p-chlorobenzoyl chloride undergo a condensation reactionso as to prepare rebamipide. The synthetic method for the intermediate has the advantages of low cost and easy availability of raw materials, short reaction steps and good optical purity.