51693-17-5Relevant articles and documents
Synthesis of N-aminomethylpyrrolidin-2-ones
Chen, Ping,Suh, Dong-Jin,Smith, Michael B.
, p. 1317 - 1322 (1995)
Pyrrolidin-2-ones react with formaldehyde and chlorotrimethylsilane to give 1-chloromethylpyrrolidin-2-ones which upon subsequent reaction with primary and secondary amines give 1-aminomethylpyrrolidin-2-ones in good yield.
Photoredox-Catalyzed Synthesis of α-Amino Acid Amides by Imine Carbamoylation
Cardinale, Luana,Jacobi Von Wangelin, Axel,Konev, Mikhail O.,Schmotz, Mattis-Ole W. S.
supporting information, (2022/01/20)
An operationally simple protocol for the photocatalytic carbamoylation of imines is reported. Easily available, bench-stable 4-amido Hantzsch ester derivatives serve as precursors to carbamoyl radicals that undergo rapid addition to N-aryl imines. The reaction proceeds under blue light irradiation in the presence of the photocatalyst 3DPAFIPN and Br?nsted/Lewis acid additives. Mechanistic studies indicated a photoredox mechanism that involves carbamoyl radicals.
A class of histone acetylase p300 inhibitors, and application thereof
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Paragraph 1087-1091, (2020/06/17)
The invention discloses a class of histone acetylase p300 inhibitors, and application thereof, and belongs to the technical field of medicinal chemistry. The invention discloses a compound representedby a formula (I), or a stereochemical isomer, a solvate or a pharmaceutically acceptable salt thereof. According to the invention, the compound can effectively inhibit the activity of histone acetylase p300 and can effectively inhibit the proliferation activity of various tumor cells; the compound is combined with a CDK4/6 inhibitor to play a synergistic role in inhibiting proliferation of tumorcells; and the compound has good application prospects in preparation of histone acetylase inhibitors, preparation of drugs for preventing and/or treating cancers, metabolic diseases, neurological diseases or inflammations, and combination of drugs.