51727-15-2

Basic information

• Product Name: 4-Chloropyridine-2-carbonyl Chloride Hydrochloride
• Synonyms: 4-Chloro-2-pyridinecarbonyl Chloride Hydrochlorid;(4-Chloro-2-pyridinecarbonyl Chloride Hydrochloride);2-Pyridinecarbonyl chloride, 4-chloro-, hydrochloride;4-chloropicolinoyl chloride hydrochloride;2-Pyridinecarbonyl chloride, 4-chloro-, hydrochloride (1:1)
• CAS NO: 51727-15-2
• Molecular Formula: C6H4Cl3NO
• Molecular Weight: 0
• EINECS: 1592732-453-0
• Product Categories: Aromatics;Heterocycles
• Mol File: 51727-15-2.mol
• Article Data: 1

Chemical Properties

• Melting Point: 135-137°C (dec.)
• Appearance: /
• Storage Temp.: -20?C Freezer, Under Inert Atmosphere
• CAS DataBase Reference: 4-Chloropyridine-2-carbonyl Chloride Hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Chloropyridine-2-carbonyl Chloride Hydrochloride(51727-15-2)
• EPA Substance Registry System: 4-Chloropyridine-2-carbonyl Chloride Hydrochloride(51727-15-2)

Safety Data

• Hazardous Substances Data: 51727-15-2(Hazardous Substances Data)

Usage

Chemical Properties

Yellow Solid

Uses

4-Chloropyridine-2-carbonyl Chloride Hydrochloride (cas# 51727-15-2) is a compound useful in organic synthesis.

Upstream product

• 98-98-6 2-Picolinic acid 

Downstream Products

• 64064-56-8 ethyl 4-chloropyridine-2-carboxylate 
• 99586-65-9 4-chloropicolinamide 
• 604813-08-3 N-isopropyl-4-chloro-2-pyridinecarboxamide 
• 1090815-16-9 N-cyclopropyl-4-chloro-2-pyridinecarboxamide 
• 114780-06-2 4-chloro-N,N-dimethylpyridine-2-carboxamide 
• 1313019-74-7 4-(4-(2-fluoro-5(trifluoromethyl)benzamido)phenoxy)-N-methylpicolinamide 
• 1313019-66-7 N-methyl-4-(4-(phenylsulfonamido)phenoxy)picolinamide 
• 847054-10-8 4-(4-(3-(2-fluoro-5-(trifluoromethyl)phenyl)ureido)phenoxy)-N-methylpyridine-2-carboxamide 

Relevant articles and documents

A new pathway via intermediate 4-amino-3-fluorophenol for the synthesis of regorafenib

A practical synthetic route to regorafenib, in which the target compound was obtained via a 10-step synthesis starting from 2-picolinic acid, 4-chloro-3-(trifluoromethyl)aniline, and 3-fluorophenol, is reported. Crucial to the strategy is the preparation of 4-amino-3-fluorophenol via Fries and Beckman rearrangements using an economical and practical protocol. The main advantages of the route include inexpensive starting materials and an acceptable overall yield. A scale-up experiment was carried out to provide regorafenib with 99.96% purity in 46.5% total yield.