51785-82-1

Basic information

• Product Name: BOC-PRO-GLY-OH
• Synonyms: BOC-PRO-GLY-OH;1-Boc-L-prolyl-glycine
• CAS NO: 51785-82-1
• Molecular Formula: C₁₂H₂₀N₂O₅
• Molecular Weight: 272.3
• Mol File: 51785-82-1.mol
• Article Data: 18

Chemical Properties

• Melting Point: 70 °C(Solv: ethyl ether (60-29-7))
• Boiling Point: 496.2±45.0 °C(Predicted)
• Appearance: /
• Density: 1.248±0.06 g/cm3(Predicted)
• Storage Temp.: -15°C
• PKA: 3.67±0.10(Predicted)
• CAS DataBase Reference: BOC-PRO-GLY-OH(CAS DataBase Reference)
• NIST Chemistry Reference: BOC-PRO-GLY-OH(51785-82-1)
• EPA Substance Registry System: BOC-PRO-GLY-OH(51785-82-1)

Safety Data

• Hazardous Substances Data: 51785-82-1(Hazardous Substances Data)

Usage

General Description

BOC-PRO-GLY-OH is a chemical compound used in the field of organic chemistry. It is a dipeptide composed of the amino acids proline and glycine, with the addition of a BOC (tert-butoxycarbonyl) protecting group. The BOC group is commonly used to protect the amine group of amino acids, helping to prevent unwanted reactions during peptide synthesis. BOC-PRO-GLY-OH is often used as a building block for the synthesis of more complex peptides or as a reference compound for analytical purposes. It is important in the development of pharmaceuticals and in the study of protein structure and function.

Upstream product

• 4530-20-5 BOC-glycine 
• 15761-39-4 1-(tert-butoxycarbonyl)-L-proline 
• 56-40-6 glycine 
• 28310-65-8 N-tert-butyloxycarbonyl-proline p-nitrophenyl ester 
• 57294-31-2 tert-butyl (S)-2-((2-ethoxy-2-oxoethyl)carbamoyl)pyrrolidine-1-carboxylate 
• 24424-99-5 di-tert-butyl dicarbonate 
• 147-85-3 L-proline 
• 109-02-4 4-methyl-morpholine 
• 1738-76-7 glycine benzyl ester p-toluenesulfonic acid salt 
• 543-27-1 isobutyl chloroformate 
• 3392-10-7 Pyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester 2-(2,5-dioxo-pyrrolidin-1-yl) ester 
• 31953-80-7 N-tert-butyloxycarbonyl-(2S)-prolyl-glycine benzyl ester 
• 15761-39-4 N-tert-butoxycarbonyl-proline 
• 57294-31-2 Boc-Pro-Gly-OEt 

Downstream Products

• 92411-00-2 Boc-Pro-Gly-Pro-OBzl 
• 34290-72-7 tert-butyloxycarbonyl-prolyl-glycine methyl ester 
• 1423168-04-0 cyclo-D-Pro-L-(Phe-Pro-His-Pro-Pro-Gly-Leu) 
• 123541-52-6 Cyclo(D-Phe-Pro-Gly-ProΨGly) 
• 123541-64-0 HCl*D-Phe-Pro-Gly-ProΨGly-OH 

Relevant articles and documents

Leonurine derivative and application thereof in preparing medicine for preventing or treating ischemic cerebrovascular diseases

The invention provides a leonurine derivative and application of the leonurine derivative in preparation of a medicine for preventing or treating ischemic cerebrovascular diseases. The leonurine derivative has a structure as shown in a general formula (I), wherein X is selected from O or NH; Y is selected from any one of natural amino acid, substituted amino acid or amino alcohol; Z is selected from H, proline and any substituted proline. Pharmacological experiments prove that the leonurine derivative provided by the invention has the effects of neuroprotection, cerebral infarction area reduction and animal neurobehavioral scoring, and is good in safety, so that the leonurine derivative has important significance for developing novel medicines for preventing or treating ischemic cerebrovascular diseases.

METHOD FOR PRODUCING RECOMBINANT PEPTIDE AND RESULTANT PEPTIDE

PROBLEM TO BE SOLVED: To provide peptides with reproductive- and sexual-function stimulating activity. SOLUTION: The peptides are represented by general formula: A-Thr-Lys-Pro-B-C-D-X (where A is 0, Met, Met(O), Thr, Ala, His, Phe, Lys, or Gly; B is 0, Gly, Asp, Trp, Gln, Asn, Tyr, Pro, or Arg; C is 0, Arg, Phe, Tyr, Gly, His, Pro, or Lys; D is 0, Val, Gly, Tyr, Trp, Phe, or His; and X is OH, OCH3, or NH2; where 0 represents absence of the amino acid residue; provided that if A≠0 then B ≠0 and/or C≠0 and/or D≠0, if B≠0 then C≠0 and/or D≠0, and peptides Phe-Thr-Lys-Pro-Gly, Thr-Lys-Pro-Pro-Arg and Thr-Lys-Pro-Arg-Gly are excluded). SELECTED DRAWING: Figure 1 COPYRIGHT: (C)2020,JPO&INPIT

Synthesis of cytotoxic cyanobactin, Wewakazole B

We report herein the synthesis of cytotoxic cyanobactin, Wewakazole B through an efficient solution-phase approach. The key steps of the synthesis are the macrocyclic lactamization of linear dodecapeptide and construction of two hexapeptides with three di