51942-54-2

Basic information

• Product Name: 3-phenyl-4,4-dimethyl-5-oxo-2-isoxazoline
• Synonyms: 3-phenyl-4,4-dimethyl-5-oxo-2-isoxazoline
• CAS NO: 51942-54-2
• Molecular Weight: 189.214
• Mol File: 51942-54-2.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: 3-phenyl-4,4-dimethyl-5-oxo-2-isoxazoline(CAS DataBase Reference)
• NIST Chemistry Reference: 3-phenyl-4,4-dimethyl-5-oxo-2-isoxazoline(51942-54-2)
• EPA Substance Registry System: 3-phenyl-4,4-dimethyl-5-oxo-2-isoxazoline(51942-54-2)

Safety Data

• Hazardous Substances Data: 51942-54-2(Hazardous Substances Data)

Upstream product

• 64407-08-5 methyl 2,2-dimethyl-3-oxo-3-phenylpropanoate 
• 611-70-1 phenyl isopropyl ketone 
• 546-67-8 lead(IV) tetraacetate 
• 99390-62-2 α-benzoylisobutyraldehyde dioxime 
• 1750-74-9 2-benzoyl-2-methylpropanal 
• 25491-42-3 ethyl 2,2-dimethyl-3-oxo-3-phenylpropionate 

Downstream Products

• 77791-12-9 6-methoxy-2-phenyl-1,3-benzoxazole 
• 1033079-57-0 7-methoxy-2-phenyl-1,3-benzoxazole 
• 125421-36-5 7-methyl-2-phenylbenzo[d]oxazole 
• 143925-49-9 2-phenyl-5-(trifluoromethyl)benzo[d]oxazole 
• 891-43-0 5-nitro-2-phenylbenzo[d]oxazole 
• 67563-39-7 2-phenylbenzo[d]oxazole-5-carbaldehyde 
• 100361-20-4 1-(2-phenylbenzo[d]oxazol-5-yl)ethan-1-one 
• 1239752-32-9 ethyl 5-carboxylic acid-2-phenylbenzoxazole 

Relevant articles and documents

Dioxygen Activation via Cu-Catalyzed Cascade Radical Reaction: An Approach to Isoxazoline/Cyclic Nitrone-Featured α-Ketols

A facile, mild, and efficient dioxygen activation for the synthesis of isoxazoline/cyclic nitrone-featured α-ketols has been achieved by Cu-catalyzed trifunctionalization of internal unactivated alkynes of unsaturated ketoximes at room temperature. 18O isotope tracing and DFT calculation reveal that a cascade iminoxyl radical dichotomous 5-exo-dig cyclization/oxygen activation/peroxy radical 4-endo-trig cyclization process was involved in the reaction.

Palladium Catalyzed Ring Expansion Reaction of Isoxazolones with Isocyanides: Synthesis of 1,3-Oxazin-6-One Derivatives

A palladium catalyzed ring expansion reaction of isoxazolones with isocyanides was disclosed. In the reaction, a cascade process involving ring-opening/cyclization was suggested. The reaction features high atomic economy due to no elimination of CO2 occurred. Moreover, products obtained demonstrate aggregation-induced emission properties with relatively high solid-state emission efficiencies. (Figure presented.).

Rhodium(III)-catalyzed synthesis of isoquinolines from aryl ketone o -acyloxime derivatives and internal alkynes

A synthetic method of isoquinolines from aryl ketone O-acyloxime derivatives and internal alkynes has been developed using [Cp*RhCl 2]2 - NaOAc as the potential catalyst system. The present transformation is carried out by a redox-neutral sequence of C - H vinylation via ortho-rhodation and C - N bond formation of the putative vinyl rhodium intermediate on the oxime nitrogen, where the N - O bond of oxime derivatives could work as an internal oxidant to maintain the catalytic cycle.