5197-62-6

Basic information

• Product Name: 2-[2-(2-CHLOROETHOXY)ETHOXY]ETHANOL
• Synonyms: 8-Chloro-3,6-dioxaoctane-1-ol;Diethylene glycol mono(2-chloroethyl) ether;2-[2-(2-Chloroethoxy)ethoxy]ethanol,95%;8-Chloro-3,6-dioxa-1-octanol;8-Chloro-3,6-dioxaoctanol;NSC 2636;2-[2-(2-Chloroethoxy)ethoxy]ethanol 96%;2-[2-(2-CHLOROETHOXY)ETHOXY]ETHANOL
• CAS NO: 5197-62-6
• Molecular Formula: C₆H₁₃ClO₃
• Molecular Weight: 168.62
• EINECS: 225-984-0
• Product Categories: Ethylene Glycols & Monofunctional Ethylene Glycols;Monofunctional Ethylene Glycols;Aliphatics;Intermediates;Polyethyleneglycol Derivatives
• Mol File: 5197-62-6.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 117-120 °C5 mm Hg(lit.)
• Flash Point: 225 °F
• Appearance: Clear slightly yellow/Liquid
• Density: 1.16 g/mL at 25 °C(lit.)
• Vapor Pressure: 0.00413mmHg at 25°C
• Refractive Index: n20/D 1.458(lit.)
• Storage Temp.: 2-8°C
• Solubility: Chloroform (Slightly)
• PKA: 14.36±0.10(Predicted)
• Stability: Stable. Combustible. Incompatible with strong oxidizing agents.
• BRN: 1739194
• CAS DataBase Reference: 2-[2-(2-CHLOROETHOXY)ETHOXY]ETHANOL(CAS DataBase Reference)
• NIST Chemistry Reference: 2-[2-(2-CHLOROETHOXY)ETHOXY]ETHANOL(5197-62-6)
• EPA Substance Registry System: 2-[2-(2-CHLOROETHOXY)ETHOXY]ETHANOL(5197-62-6)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36-37/39
• WGK Germany: 3
• Hazardous Substances Data: 5197-62-6(Hazardous Substances Data)

Usage

Chemical Properties

colourless liquid

Uses

Different sources of media describe the Uses of 5197-62-6 differently. You can refer to the following data:
1. 2-[2-(2-Chloroethoxy)ethoxy]ethanol is used in the preparation of ethylene glycol based amino acids. 2-[2-(2-Chloroethoxy)ethoxy]ethanol is also used in the preparation of polymers for direct and amplified DNA detection.
2. 2-[2-(2-Chloroethoxy)ethoxy]ethanol was used in the synthesis of 1-[3-(2-aminoethyl)-1H-indol-5-yloxy]-3,6-dioxa-8-mercaptooctane. It was also used in the synthesis of modified oligonucleotides bearing a disulfide or a thiol function at the 3′-end and other modifications at the 5′-end.

InChI:InChI=1/C6H13ClO3/c7-1-3-9-5-6-10-4-2-8/h8H,1-6H2

Upstream product

• 75-21-8 oxirane 
• 107-07-3 2-chloro-ethanol 
• 107-21-1 ethylene glycol 
• 7664-93-9 sulfuric acid 
• 112-27-6 2,2'-[1,2-ethanediylbis(oxy)]bisethanol 
• 628-89-7 2-(2-Chloroethoxy)ethanol 

Downstream Products

• 72606-97-4 3,5-Bis-(2-{2-[2-(toluene-4-sulfonyloxy)-ethoxy]-ethoxy}-ethoxy)-benzoic acid butyl ester 
• 134881-72-4 1,4-bis-(2-(2-(2-hydroxyethoxy)ethoxy)ethoxy)benzene 
• 167567-16-0 2-[2-[2-(4-methoxyphenoxy)ethoxy]ethoxy]ethanol 
• 186365-67-3 2-{2-[2-(4,5-Dibromo-2-methoxy-phenoxy)-ethoxy]-ethoxy}-ethanol 
• 366470-09-9 8-[(2-nitrophenylthio)]-3,6-dioxaoctanol 
• 170304-76-4 2-(2-(2-chloroethoxy)ethoxy)ethanoic acid 
• 932741-19-0 2-(2-(2-(prop-2-yn-1-yloxy)ethoxy)ethoxy)ethanamine 
• 932741-18-9 3-(2-(2-(2-azidoethoxy)ethoxy)ethoxy)-prop-1-yne 
• 260351-08-4 3-O-[8-Benzyloxy-3,6-dioxaoctyl]-sn-glycerol 
• 260350-94-5 3-O-[8-Benzyloxy-3,6-dioxaoctyl]-1,2-O-isopropylidene-sn-glycerol 
• 260351-09-5 3-O-[8-Benzyloxy-3,6-dioxaoctyl]-1,2-di-O-hexadecyl-sn-glycerol 
• 260351-11-9 3-O-[17-Benzyloxy-3,6,9,12,15-pentaoxaheptadecyl]-1,2-di-O-hexadecyl-sn-glycerol 
• 260351-13-1 3-O-[26-Benzyloxy-3,6,9,12,15,18,21,24-octaoxahexacosyl]-1,2-di-O-hexadecyl-sn-glycerol 
• 223611-38-9 C₂₅H₂₇ClO₃ 

Relevant articles and documents

Smooth receptor ligand

The invention relates to the technical field of biology, particularly to a smooth receptor ligand, and provides a smooth receptor ligand or an isomer prodrug, a solvate and a pharmaceutically acceptable salt thereof, wherein the structural formula of the smooth receptor ligand is A-linker-B, A is an extracellular domain ligand structure, B is a transmembrane domain ligand structure, and Linker isa linear subunit inactive to the smooth receptor. According to the novel double-end small molecule ligand for the smooth receptor, by combining the crystal structure data of the smooth receptor, a linker is introduced into the proper sites of an extracellular domain ligand and a transmembrane domain ligand to obtain brand-new double-end ligand small molecules, so that the interaction between the ligand and the receptor and the biological activity of the ligand are enhanced.

A 2- chlorine ethoxy group -2-ethoxy-ethanol preparation method (by machine translation)

The invention discloses a preparation method of 2-chloroethoxy-2-ethyoxylethanol. The preparation method comprises the steps: with 2-chloroethoxy and ethylene oxide as raw materials, performing a reaction in the presence of a catalyst to firstly obtain 2-ethyoxylethanol, removing the remaining solvent, namely a reactant 2-chlorohydrin, making the 2-ethyoxylethanol continuously react with the re-added ethylene oxide to obtain a target product 2-chloroethoxy-2-ethyoxylethanol. The preparation method has the advantages of being easy to operate during reaction, mild in system, less in side reactions, high in content and yield of products, and less in pollutants generated during the reaction.