52-72-2Relevant articles and documents
Facile ring opening of 2,3-epoxy-steroids with aromatic amines in ionic liquids
Horvath, Anita,Skoda-Foeldes, Rita,Maho, Sandor,Berente, Zoltan,Kollar, Laszlo
, p. 706 - 711 (2006)
Efficient ring opening of steroidal 2,3-epoxides with stoichiometric amount of aromatic amines has been carried out using an ionic liquid ([bmim]+[BF4]-) both as solvent and catalyst. The reactions were completely regio- a
Novel method for preparing rocuronium bromide
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, (2017/11/18)
The invention relates to a novel method for preparing rocuronium bromide 1-[17beta-acetoxyl-3alpha-hydroxyl-2beta-(4-morpholinyl)-androstane-16beta-yl]-1-(2-propenyl) pyrrole bromide, the problem of chemoselectivity of pyrrolidine open epoxy in an original line is solved, generation of byproducts is avoided, reaction yield is greatly improved, the production cost is reduced, column chromatography separation is avoided, and aftertreatment purification is implemented easily.