520-11-6

Basic information

• Product Name: 6-METHOXYLUTEOLIN
• Synonyms: EUPAFOLIN;6-METHOXYLUTEOLIN;NEPETIN;Eurafolin;Eupafloin 6-Methoxyluteolin;2-(3,4-Dihydroxyphenyl)-5,7-dihydroxy-6-methoxy-4H-1-benzopyran-4-one;2-(3-Hydroxy-4-hydroxyphenyl)-5,7-dihydroxy-6-methoxy-4H-1-benzopyran-4-one;NSC 122416
• CAS NO: 520-11-6
• Molecular Formula: C₁₆H₁₂O₇
• Molecular Weight: 316.26
• Product Categories: Tetra-substituted Flavones
• Mol File: 520-11-6.mol
• Article Data: 4

Chemical Properties

• Melting Point: 267°C
• Boiling Point: 659.058 °C at 760 mmHg
• Flash Point: 90℃
• Appearance: /
• Density: 1.605
• Vapor Pressure: 5.64E-18mmHg at 25°C
• Refractive Index: 1.727
• Storage Temp.: 2-8°C
• PKA: 6.48±0.40(Predicted)
• CAS DataBase Reference: 6-METHOXYLUTEOLIN(CAS DataBase Reference)
• NIST Chemistry Reference: 6-METHOXYLUTEOLIN(520-11-6)
• EPA Substance Registry System: 6-METHOXYLUTEOLIN(520-11-6)

Safety Data

• Hazardous Substances Data: 520-11-6(Hazardous Substances Data)

Usage

Description

6-Methoxyluteolin, a natural flavonoid compound, is derived from plants such as Desmodium gangeticum and Solidago canadensis. It is recognized for its potential anti-inflammatory, antioxidant, and anticancer properties, making it a promising candidate for the development of new therapeutic agents for treating cancer, inflammation, and oxidative stress-related diseases.

Uses

Used in Pharmaceutical Industry:
6-Methoxyluteolin is used as an anti-inflammatory agent for its ability to inhibit the production of pro-inflammatory cytokines, which can help in reducing inflammation in the body.
6-Methoxyluteolin is used as an antioxidant for its capacity to protect cells from oxidative damage, which can contribute to the prevention and treatment of oxidative stress-related diseases.
Used in Oncology:
6-Methoxyluteolin is used as an anticancer agent for its ability to inhibit the growth of certain cancer cells and induce apoptosis, offering potential therapeutic benefits in the treatment of various types of cancer.
Used in Drug Development:
6-Methoxyluteolin is used as a lead compound in the development of new therapeutic agents targeting inflammation, oxidative stress, and cancer, due to its multifaceted biological activities and potential for further research and formulation into effective treatments.

InChI:InChI=1/C16H12O7/c1-22-16-11(20)6-13-14(15(16)21)10(19)5-12(23-13)7-2-3-8(17)9(18)4-7/h2-6,17-18,20-21H,1H3

Upstream product

• 88153-47-3 5,6-Dimethoxy-7,3',4'-trihydroxyflavone 
• 569-90-4 5,7,3',4'-tetrahydroxy-6-methoxyflavone-7-O-β-D-glucopyranoside 

Downstream Products

• 82657-12-3 C₂₂H₂₀O₁₃ 
• 18003-33-3 3',4',5,6,7-pentahydroxyflavone 

Relevant articles and documents

New Flavonoids and Turkesterone-2-O-Cinnamate from Leaves of Rhaponticum uniflorum

Leaves of Rhaponticum uniflorum (L.) DC. (Asteraceae) afforded 46 compounds including seven new flavonoids that were identified using UV, IR, and NMR spectroscopy and mass spectrometry as 6-hydroxyluteolin-7-O-(2′-O-caffeoyl)-β-D-glucopyranoside (rhaunoside A, 1), 6-hydroxyluteolin-7-O-(6″-O-cinnamoyl)-β-D-glucopyranoside (rhaunoside B, 2), 6-hydroxyluteolin-4′-O-β-D-glucopyranoside (rhaunoside C, 3), nepetin-7-O-(6″-O-caffeoyl)-β-D-glucopyranoside (rhaunoside D, 4), nepetin-7-O-(6″-O-cinnamoyl)-β-D-glucopyranoside (rhaunoside E, 5), nepetin-3′-O-β-D-glucopyranoside (rhaunoside F, 6), and luteolin-7-O-(2″-O-caffeoyl)-β-D-glucopyranoside (rhaunoside G, 7) and the new ecdysteroid turkesterone-2-O-cinnamate (8).

Gastroprotective flavone/flavanone compounds with therapeutic effect on inflammatory bowel disease

PCT No. PCT/KR97/00144 Sec. 371 Date Jan. 14, 1999 Sec. 102(e) Date Jan. 14, 1999 PCT Filed Jul. 25, 1997 PCT Pub. No. WO98/04541 PCT Pub. Date Feb. 5, 1998The present invention relates to novel flavone/flavanone compounds or their pharmaceutically acceptable salts and process for preparation thereof for protecting gastrointestinal tracts against gastritis, ulcers and inflammatory bowel disease.