523-86-4

Basic information

• Product Name: 2,6-Piperidinedione, 4-(2-hydroxy-2-(5-hydroxy-3,5-dimethyl-2-oxocyclo hexyl)ethyl)-
• Synonyms: 2,6-Piperidinedione, 4-(2-hydroxy-2-(5-hydroxy-3,5-dimethyl-2-oxocyclo hexyl)ethyl)-;streptovitacin A;4-[2-Hydroxy-2-(5-hydroxy-3,5-dimethyl-2-oxocyclohexyl)ethyl]-2,6-piperidinedione;NSC-39147;Resactin A;U-9361;(-)-3-(2-HYDROXY-2-(5-HYDROXY-3,5-DIETHYL-2-OXOCYCLOHEXYL)ETHYL)GLUTARIMIDE;Aids031107
• CAS NO: 523-86-4
• Molecular Formula: C₁₅H₂₃NO₅
• Molecular Weight: 297.39
• Mol File: 523-86-4.mol
• Article Data: 3

Chemical Properties

• Melting Point: 157.5°C
• Boiling Point: 438.86°C (rough estimate)
• Flash Point: 277.4°C
• Appearance: /
• Density: 1.1232 (rough estimate)
• Vapor Pressure: 1.1E-13mmHg at 25°C
• Refractive Index: 1.5000 (estimate)
• CAS DataBase Reference: 2,6-Piperidinedione, 4-(2-hydroxy-2-(5-hydroxy-3,5-dimethyl-2-oxocyclo hexyl)ethyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 2,6-Piperidinedione, 4-(2-hydroxy-2-(5-hydroxy-3,5-dimethyl-2-oxocyclo hexyl)ethyl)-(523-86-4)
• EPA Substance Registry System: 2,6-Piperidinedione, 4-(2-hydroxy-2-(5-hydroxy-3,5-dimethyl-2-oxocyclo hexyl)ethyl)-(523-86-4)

Safety Data

• Hazardous Substances Data: 523-86-4(Hazardous Substances Data)

Usage

General Description

2,6-Piperidinedione, 4-(2-hydroxy-2-(5-hydroxy-3,5-dimethyl-2-oxocyclohexyl)ethyl)- is a chemical compound with the molecular formula C12H19NO5. It is a cyclic compound containing a piperidinedione ring with a hydroxyethyl group attached at the 4-position. 2,6-Piperidinedione, 4-(2-hydroxy-2-(5-hydroxy-3,5-dimethyl-2-oxocyclo hexyl)ethyl)- is synthesized through the reaction of 2,6-piperidinedione with 5-hydroxy-3,5-dimethyl-2-oxocyclohexanone, resulting in the formation of the hydroxyethyl group. It may have potential uses in pharmaceuticals or industrial applications due to its unique structural and chemical properties. Further research and studies are needed to fully understand its potential applications.

InChI:InChI=1/C15H23NO5/c1-8-6-15(2,21)7-10(14(8)20)11(17)3-9-4-12(18)16-13(19)5-9/h8-11,17,21H,3-7H2,1-2H3,(H,16,18,19)

Upstream product

• 131077-79-7 trans-2,4-dimethyl-4-trimethylsiloxy-1-cyclohexanone 
• 131077-81-1 4-[2-((3S,5S)-3,5-Dimethyl-2-oxo-5-trimethylsilanyloxy-cyclohexyl)-2-hydroxy-ethyl]-piperidine-2,6-dione 
• 131077-81-1 4-[2-((3R,5S)-3,5-Dimethyl-2-oxo-5-trimethylsilanyloxy-cyclohexyl)-2-hydroxy-ethyl]-piperidine-2,6-dione 
• 131077-78-6 4-methyl-4-(trimethylsilyloxy)cyclohexanone 
• 131057-03-9 1-methyl-4-tetrahydropyranyloxy-1-cyclohexanol 
• 13482-22-9 4-hydroxycyclohexanone 
• 17429-02-6 4-hydroxy-4-methylcyclohexanone 
• 89794-52-5 1-methyl-1,4-cyclohexanediol 
• 60739-53-9 4-(tetrahydro-2H-pyran-2-yloxy)cyclohexanone 
• 131077-79-7 cis-2,4-dimethyl-4-trimethylsiloxy-1-cyclohexanone 
• 1001-75-8 4-methyl-4-pentenoic acid 
• 1149347-46-5 3-[(dodecylthio-carbonyl)-methyl]-glutarimide 
• 66-81-9 Cycloheximide 

Downstream Products

• 2885-39-4 (+/-)-E-73 
• 131057-04-0 Acetic acid (1R,3S,5S)-3-[(R)-2-(2,6-dioxo-piperidin-4-yl)-1-triethylsilanyloxy-ethyl]-1,5-dimethyl-4-oxo-cyclohexyl ester 
• 4348-89-4 4-(2-hydroxy-3,5-dimethyl-phenethyl)-piperidine-2,6-dione 
• 131057-05-1 4-[(R)-2-((1S,3S,5R)-5-Hydroxy-3,5-dimethyl-2-oxo-cyclohexyl)-2-triethylsilanyloxy-ethyl]-piperidine-2,6-dione 

Relevant articles and documents

Versatile Synthetic Route to Cycloheximide and Analogues That Potently Inhibit Translation Elongation

Cycloheximide (CHX) is an inhibitor of eukaryotic translation elongation that has played an essential role in the study of protein synthesis. Despite its ubiquity, few studies have been directed towards accessing synthetic CHX derivatives, even though such efforts may lead to protein synthesis inhibitors with improved or alternate properties. Described here is the total synthesis of CHX and analogues, and the establishment of structure–activity relationships (SAR) responsible for translation inhibition. The SAR studies aided the design of more potent compounds, one of which irreversibly blocks ribosomal elongation, preserves polysome profiles, and may be a broadly useful tool for investigating protein synthesis.

Syntheses and biological activities of (+/-)-streptovitacin A and E-73.

(+/-)-Streptovitacin A (1) and its stereoisomers were synthesized by an aldol reaction of (+/-)-2,4-dimethyl-4-trimethylsiloxy-1-cyclohexanones (4b and 9) with 4-(2-oxoethyl)-2,6-piperidinedione (5). E-72 (2) was derived from synthetic 1. (+/-)-1 showed m