52341-70-5

Basic information

• Product Name: 1-Azetidinesulfonyl chloride, 2-oxo-4-phenyl-
• CAS NO: 52341-70-5
• Molecular Formula: C9H8ClNO3S
• Molecular Weight: 245.686
• Mol File: 52341-70-5.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 1-Azetidinesulfonyl chloride, 2-oxo-4-phenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Azetidinesulfonyl chloride, 2-oxo-4-phenyl-(52341-70-5)
• EPA Substance Registry System: 1-Azetidinesulfonyl chloride, 2-oxo-4-phenyl-(52341-70-5)

Safety Data

• Hazardous Substances Data: 52341-70-5(Hazardous Substances Data)

Upstream product

• 100-42-5 styrene 
• 1189-71-5 isocyanate de chlorosulfonyle 

Downstream Products

• 97216-19-8 3-amino-3,N-diphenyl-propionamide 
• 91061-49-3 3-methoxy-3-phenyl-propionic acid 
• 88909-10-8 (R,S)-4-phenyl-1,5-diazacyclooctan-2-one 
• 89044-91-7 N-(3-isopropylaminopropyl)-4-phenylazetidin-2-one 
• 89044-86-0 N-(4-aminobutyl)-4-phenylazetidin-2-one 
• 154219-02-0 N-<3-(2-cyanoethylamino)propyl>-4-phenylazetidin-2-one 
• 154218-71-0 1-(3-chloropropyl)-4-phenyl-1,5-diazacyclononan-2-one 
• 154218-72-1 1-(3-chloropropyl)-4-phenyl-1,5-diazacyclooctan-2-one 
• 104197-26-4 4-phenyl-1,5,9-triazacyclododecan-2-one 
• 154218-96-9 1-(7-amino-4-azaheptyl)-4-phenylazetidin-2-one 

Relevant articles and documents

Synthesis of β-amino acid derivatives and their inhibitory profiles against some metabolic enzymes

Sulfamate and its derivatives have a range of biological activities. One-pot cyclocondensation of alkenes (1a–i) with chlorosulfonyl isocyanate generates β-lactams. β-Amino acid derivatives (2a–i) from β-lactams were synthesized. Then, these highly reacti

Study of the Transamidative Ring Expansion of N-ω-Halogenoalkyl-β-lactams of Alkyl Chain Lengths 2-12 in Liquid Ammonia and Other Liquid Amines: Syntheses of 7-, 8- and 9-Membered 1,5-Diaza Cyclic Ketones, including Routes to (+/-)-Dihydroperiphylline and (+/-)-Celabenzine

N-(3-Halogenopropyl)-4-phenylazetidin-2-ones undergo amination in liquid ammonia followed by transamidative ring expansion to give the eight-membered 4-phenyl-1,5-diazacyclooctan-2-one in excellent yield.Ring expansion of the amines in liquid ammonia is found to be much more effective than in hydrocarbon solvents.Formation of 7-, 8-, and 9-membered azalactams from the requisite ω-halogenoalkyl-β-lactams is an excellent synthetic process, though it is not applicable to 10-membered rings.In the case of rings of 13-, 15- and 17-members, although amination and apparent expansion takes place, the large rings appear not to be stable to ammonia and the final products are acyclic amides.N--4-phenylazetidin-2-one satisfactorily forms a 9-membered (Z)-olefinic azalactam, but the (E)-isomer gives an acyclic amino amide.By using alkyl-substituted β-lactam side-chains, C-substituted medium rings can be obtained; the relative instability of N-acyl β-lactams to ammonia, however, leads to acylamino amides rather than expanded rings.Employing ethylamine in place of ammonia, it is shown that N-ethylated azalactams are formed satisfactorily, and using allylamine, N-allyl medium rings capable of further elaboration are obtained.The chemistry of these systems is discussed.Using transamidation in liquid ammonia, a short synthesis of the 9-membered spermidine alkaloid (+/-)-dihydroperiphylline is reported.Synthesis of key intermediates, whose transformation into the 13-membered alkaloids of the celabenzine group has already been effected, has been carried out.X-Ray single-crystal structure determinations for 4-phenyl-1,5-diazacyclononan-2-one, trans-4-phenyl-8-methyl-1,5-diazacyclooctan-2-one and (Z)-4-phenyl-1,5-diazacyclonon-7-en-2-one are reported, and comment is made on certain conformational features.