524-38-9Relevant articles and documents
Reactivity of phthalimide N-oxyl radical (PINO) toward the phenolic O-H bond. A kinetic study
Baciocchi, Enrico,Gerini, Maria Francesca,Lanzalunga, Osvaldo
, p. 8963 - 8966 (2004)
The reactivity of the phthalimide N-oxyl radical (PINO) toward the OH bond of a series of substituted phenols was kinetically investigated in CH 3CN. The reaction selectivity and the deuterium kinetic isotope effect were determined. Information on the kinetic solvent effect was also obtained with phenol as the substrate.
Synthesis, Crystal Structure, Herbicidal Activity, and SAR Study of Novel N-(Arylmethoxy)-2-chloronicotinamides Derived from Nicotinic Acid
Yu, Chen-Sheng,Wang, Qiao,Bajsa-Hirschel, Joanna,Cantrell, Charles L.,Duke, Stephen O.,Liu, Xing-Hai
, p. 6423 - 6430 (2021/06/28)
Nicotinic acid, also known as niacin, is a natural product, which is widely found in plants and animals. To discover novel natural-product-based herbicides, a series of N-(arylmethoxy)-2-chloronicotinamides were designed and synthesized. Some of the new N-(arylmethoxy)-2-chloronicotinamides exhibited excellent herbicidal activity against Agrostis stolonifera (bentgrass) at 100 μM. Compound 5f (2-chloro-N-((3,4-dichlorobenzyl)oxy)nicotinamide) possessed excellent herbicidal activity against Lemna paucicostata (duckweed), with an IC50 value of 7.8 μM, whereas the commercial herbicides clomazone and propanil had values of 125 and 2 μM, respectively. The structure-activity relationships reported in this paper could be used for the development of new herbicides against monocotyledonous weeds.
Synthesis method N -hydroxyphthalimide
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Paragraph 0015-0022, (2021/09/15)
The invention discloses a synthesis method of N -hydroxyphthalimide. The reaction is carried out by reflux dehydration and dehydrochlorination in a high boiling point inert solvent by taking phthalic anhydride and hydroxylamine hydrochloride as raw materials, and N - hydroxyphthalimide is obtained in a high yield after the reaction is finished. The molar yield can reach above 98%, and the purity of the product reaches 99% or above. Compared with the prior art, the high-boiling-point inert solvent replaces a traditional water or dioxane aqueous solution as a solvent, so that a large amount of waste water generated is avoided. Pollution emission is reduced, production efficiency is improved, conversion rate is increased, and atom utilization rate is saved.