52402-78-5

Basic information

• Product Name: [2-(BIPHENYL-4-YLOXY)-ETHYL]-DIMETHYL-AMINE
• Synonyms: [2-(BIPHENYL-4-YLOXY)-ETHYL]-DIMETHYL-AMINE
• CAS NO: 52402-78-5
• Molecular Formula: C₁₆H₁₉NO
• Molecular Weight: 241.32816
• Mol File: 52402-78-5.mol

Chemical Properties

• Boiling Point: 365.3±35.0 °C(Predicted)
• Appearance: /
• Density: 1.024±0.06 g/cm3(Predicted)
• PKA: 8.77±0.28(Predicted)
• CAS DataBase Reference: [2-(BIPHENYL-4-YLOXY)-ETHYL]-DIMETHYL-AMINE(CAS DataBase Reference)
• NIST Chemistry Reference: [2-(BIPHENYL-4-YLOXY)-ETHYL]-DIMETHYL-AMINE(52402-78-5)
• EPA Substance Registry System: [2-(BIPHENYL-4-YLOXY)-ETHYL]-DIMETHYL-AMINE(52402-78-5)

Safety Data

• Hazardous Substances Data: 52402-78-5(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
[2-(BIPHENYL-4-YLOXY)-ETHYL]-DIMETHYL-AMINE is used as an intermediate compound for the synthesis of various pharmaceutical products. Its unique structure, which combines the properties of biphenyl and dimethylamine, may offer novel therapeutic applications and enhance the development of new drugs.
Used in Chemical Industry:
In the chemical industry, [2-(BIPHENYL-4-YLOXY)-ETHYL]-DIMETHYL-AMINE can be used as a building block for the creation of more complex molecules with specific properties. Its potential applications may include the development of new dyes, pesticides, and other industrial chemicals that require the unique characteristics of this compound.
Used in Research and Development:
Due to its novel structure, [2-(BIPHENYL-4-YLOXY)-ETHYL]-DIMETHYL-AMINE may be employed in research and development efforts to explore its potential applications and properties. This could involve testing its interactions with other compounds, evaluating its stability under various conditions, and assessing its potential for use in specific industries or applications.

Upstream product

• 591-50-4 iodobenzene 
• 622-76-4 1-phenyl-1-butyne 
• 194594-60-0 (4-(2-(dimethylamino)ethoxy)phenyl)boronic acid 

Downstream Products

• 2401-52-7 C₄₂H₅₈N₂O₂⁽²⁺⁾*2Br^(1-) 

Relevant articles and documents

Regio- and stereoselective route to tetrasubstituted olefins by the palladium-catalyzed three-component coupling of aryl iodides, internal alkynes, and arylboronic acids

The Pd-catalyzed three-component coupling of readily available aryl iodides, internal alkynes, and arylboronic acids provides a convenient, one-step, regio- and stereoselective route to tetrasubstituted olefins in good to excellent yields, although electron-poor aryl iodides and dialkylalkynes normally afford only low yields under our standard reaction conditions. The proper combination of substrates and reaction conditions is important for high yields. The presence of water generally substantially increases the yields of the desired tetrasubstituted olefins. The reaction involves cis-addition of the aryl group from the aryl iodide to the less hindered or more electron-rich end of the alkyne, while the aryl group from the arylboronic acid adds to the other end. A modified, room-temperature procedure has also been successfully developed, which works very well for some substrates. Tamoxifen and its derivatives are synthesized in a concise, regio- and stereoselective manner by applying our synthetic protocol.