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2-TERT-BUTOXYCARBONYLAMINO-3-OXO-OCTAHYDRO-INDOLIZINE-5-CARBOXYLIC ACID METHYL ESTER is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

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  • 524958-63-2 Structure
  • Basic information

    1. Product Name: 2-TERT-BUTOXYCARBONYLAMINO-3-OXO-OCTAHYDRO-INDOLIZINE-5-CARBOXYLIC ACID METHYL ESTER
    2. Synonyms: 2-TERT-BUTOXYCARBONYLAMINO-3-OXO-OCTAHYDRO-INDOLIZINE-5-CARBOXYLIC ACID METHYL ESTER
    3. CAS NO:524958-63-2
    4. Molecular Formula: C15H24N2O5
    5. Molecular Weight: 312.36146
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 524958-63-2.mol
  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: 460.5±34.0 °C(Predicted)
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: 1.21±0.1 g/cm3(Predicted)
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. PKA: 11.35±0.40(Predicted)
    10. CAS DataBase Reference: 2-TERT-BUTOXYCARBONYLAMINO-3-OXO-OCTAHYDRO-INDOLIZINE-5-CARBOXYLIC ACID METHYL ESTER(CAS DataBase Reference)
    11. NIST Chemistry Reference: 2-TERT-BUTOXYCARBONYLAMINO-3-OXO-OCTAHYDRO-INDOLIZINE-5-CARBOXYLIC ACID METHYL ESTER(524958-63-2)
    12. EPA Substance Registry System: 2-TERT-BUTOXYCARBONYLAMINO-3-OXO-OCTAHYDRO-INDOLIZINE-5-CARBOXYLIC ACID METHYL ESTER(524958-63-2)
  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 524958-63-2(Hazardous Substances Data)

524958-63-2 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 524958-63-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 5,2,4,9,5 and 8 respectively; the second part has 2 digits, 6 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 524958-63:
(8*5)+(7*2)+(6*4)+(5*9)+(4*5)+(3*8)+(2*6)+(1*3)=182
182 % 10 = 2
So 524958-63-2 is a valid CAS Registry Number.

524958-63-2Downstream Products

524958-63-2Relevant articles and documents

Synthesis of protected (2S,6S,8S)-indolizin-9-one amino acid

Shimizu, Masaki,Nemoto, Hideo,Kakuda, Hiroko,Takahata, Hiroki

, p. 245 - 255 (2007/10/03)

First synthesis of (2S,6S,8S)-indolizidin-9-one amino acid starting from 1,6-heptadiene has been described.

An olefination entry for the synthesis of enantiopure α,ω-diaminodicarboxylates and azabicyclo[X.Y.0]alkane amino acids

Gosselin, Francis,Lubell, William D.

, p. 7463 - 7471 (2007/10/03)

A new approach for synthesizing α,ω-diaminodicarboxylates of various chain lengths has opened the way for making a series of azabicyclo[X.Y.0]alkane amino acids of different ring sizes. β-Keto phosphonates 21-23 were synthesized in 71-90% yield by the addition of the lithium anion of dimethyl methyl phosphonate to the ω-methyl ester of α.-tert-butyl N-(PhF)aspartate 3, glutamate 9, and aminoadipate 12 (PhF = 9-phenylfluoren-9-yl). α,ω-Diaminodicarboxylates 24-26 of nine to eleven carbon chain lengths were prepared in 78-87% yield from the Horner-WadsworthEmmons olefination of α-tert-butyl .ZV-(PhF)aspartatc β-aldehyde (5) with aminodicarboxylate-derived β-keto phosphonates 21-23. The power of this approach for making azabicyclo[X.Y.0]alkane amino acid was then illustrated by the first synthesis of enantiopure indolizidin-9-one amino acid 2 in nine steps and >25% overall yield from inexpensive aspartic acid as chiral educt. Hydrogenation of (2S,8S)-di-tcrt-butyl 4-oxo-2,8-bis[N-(PhF)amino]non-4-enedioate (24) in 9:1 EtOH:AcOH furnished a 9:1 diastereomeric mixture of 6-alkylpipecolate 28 that was subsequently transformed into azabicyclo[4.3.0]alkane amino acid 2 via lactam cyclization and protecting group manipulations. Because α,ω-diaminodicarboxylates 25 and 26 may be similarly converted to heterocycles of larger ring sizes and because alkylation of similar ketones can be used to attach side-chains at different points on the heterocycle, this olefination strategy greatly expands our methodology for synthesizing azabicyclo[X.Y.0]alkane amino acids for the exploration of conformation-activity relationships of various biologically active peptides.

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