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52499-04-4

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52499-04-4 Usage

General Description

5-Thiazolecarboxamide, 2-amino (9CI) is a chemical compound with the molecular formula C4H4N2OS. It is a thiazole carboxamide derivative that contains an amino group attached to the carbon at position 2 of the thiazole ring. The compound may have potential applications in the field of pharmaceuticals and agrochemicals due to its molecular structure and properties. Research on this compound is ongoing to explore its potential uses and to understand its effects on biological systems. Additionally, the compound may be used as a building block for the synthesis of other organic compounds with similar structural features and properties.

Check Digit Verification of cas no

The CAS Registry Mumber 52499-04-4 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,2,4,9 and 9 respectively; the second part has 2 digits, 0 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 52499-04:
(7*5)+(6*2)+(5*4)+(4*9)+(3*9)+(2*0)+(1*4)=134
134 % 10 = 4
So 52499-04-4 is a valid CAS Registry Number.

52499-04-4SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 17, 2017

Revision Date: Aug 17, 2017

1.Identification

1.1 GHS Product identifier

Product name 2-Aminothiazole-5-carboxamide

1.2 Other means of identification

Product number -
Other names 2-Amino-1,3-thiazole-5-carboxamide

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:52499-04-4 SDS

52499-04-4Relevant articles and documents

Identification of 5-Substituted 2-Acylaminothiazoles That Activate Tat-Mediated Transcription in HIV-1 Latency Models

Nguyen, William,Jacobson, Jonathan,Jarman, Kate E.,Jousset Sabroux, Helene,Harty, Leigh,McMahon, James,Lewin, Sharon R.,Purcell, Damian F.,Sleebs, Brad E.

, p. 5148 - 5175 (2019/05/28)

The persistent reservoir of cells latently infected with human immunodeficiency virus (HIV)-integrated proviral DNA necessitates lifelong suppressive antiretroviral therapy (ART). Epigenetic targeted compounds have shown promise as potential latency-reversing agents; however, these drugs have undesirable toxicity and lack specificity for HIV. We utilized a novel HEK293-derived FlpIn dual-reporter cell line, which quantifies specific HIV provirus reactivation (LTR promoter) relative to nonspecific host cell gene expression (CMV promoter), to identify the 5-substituted 2-acylaminothiazole hit class. Here, we describe the optimization of the hit class, defining the functionality necessary for HIV gene activation and for improving in vitro metabolism and solubility. The optimized compounds displayed enhanced HIV gene expression in HEK293 and Jurkat 10.6 latency cellular models and increased unspliced HIV RNA in resting CD4+ T cells isolated from HIV-infected individuals on ART, demonstrating the potential of the 2-acylaminothiazole class as latency-reversing agents.

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