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525-79-1

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525-79-1 Usage

Description

Different sources of media describe the Description of 525-79-1 differently. You can refer to the following data:
1. Kinetin (or Vivakin) was introduced as Kinerase in the US as a new ingredient for the treatment of age related photodamage of skin. This 6- furfurylaminopurine is a synthetic cytokinin, a family of plant growth factors, and was shown to be a highly potent growth factor. In vitro, it was able to delay or prevent the onset of age-related changes in skin cells without affecting cellular lifespan. In a double-blind clinical trial, Kinetin (0.005%) partially reversed the clinical signs of photodamaged skin and demonstrated a good safety profile. It could have potential in psoriasis as well as in other proliferative skin disorders.
2. Kinetin is a cytokinin plant growth regulator with diverse biological activities. Kinetin (0.23 μM) increases p34cdc2-like histone H1 kinase activity, the number of cells in mitosis, and total cell number in arrested N. plumbaginifolia cells. It increases GSH levels and activity of glutathione peroxidase and glutathione reductase, but reduces thiobarbituric acid reactive substances (TBARS) levels, in human skin fibroblasts when used at a concentration of 10 μM. Kinetin (40 μM) reduces age-related enlargement, multinucleation, and accumulation of cellular debris in human mammary skin fibroblasts without affecting proliferative lifespan.

Chemical Properties

White Solid

Originator

Senetek (UK)

Uses

Different sources of media describe the Uses of 525-79-1 differently. You can refer to the following data:
1. auxin, plant growth regulator, plant cell division promotor
2. Plant growth accelerator
3. Plant growth regulator. To augment growth of microbial cultures: BE 632589 (1963 to Hoechst).
4. Kinetin acts as plant growth accelerator, auxin, plant growth regulator, plant cell division promotor. It also acts as cell division factor found in various plant parts and in yeast. A plant growth regulator. Augments growth of microbial cultures.

Brand name

Kinerase

Synthesis Reference(s)

The Journal of Organic Chemistry, 21, p. 1276, 1956 DOI: 10.1021/jo01117a016

General Description

Kinetin is an artificial?cytokinin, obtained from herring sperm. It is named due to its ability to stimulate cell division.

Biochem/physiol Actions

FAPα has in vitro dipeptidyl peptidase activity and collagenolytic activity. It cleaves N-terminal dipeptides from polypeptides and can degrade gelatin and type I collagen. It has also been reported that FAPa has a tumor suppressor activity.

Purification Methods

It forms platelets from EtOH and sublimes at 220o, but is best done at lower temperatures in a good vacuum. It has been extracted from neutral aqueous solutions with Et2O. [Miller et al J Am Chem Soc 78 1375 1956, Bullock et al. J Am Chem Soc 78 3693 1956, Beilstein 26 III/IV 3586.]

Check Digit Verification of cas no

The CAS Registry Mumber 525-79-1 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 5,2 and 5 respectively; the second part has 2 digits, 7 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 525-79:
(5*5)+(4*2)+(3*5)+(2*7)+(1*9)=71
71 % 10 = 1
So 525-79-1 is a valid CAS Registry Number.

525-79-1 Well-known Company Product Price

  • Brand
  • (Code)Product description
  • CAS number
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  • Detail
  • Alfa Aesar

  • (A13720)  Kinetin, 99%   

  • 525-79-1

  • 1g

  • 203.0CNY

  • Detail
  • Alfa Aesar

  • (A13720)  Kinetin, 99%   

  • 525-79-1

  • 5g

  • 757.0CNY

  • Detail
  • Alfa Aesar

  • (A13720)  Kinetin, 99%   

  • 525-79-1

  • 25g

  • 3436.0CNY

  • Detail

525-79-1SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 17, 2017

Revision Date: Aug 17, 2017

1.Identification

1.1 GHS Product identifier

Product name kinetin

1.2 Other means of identification

Product number -
Other names 6-Furfurylaminopurine,N6-Furfuryladenine

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:525-79-1 SDS

525-79-1Synthetic route

3,4-dihydro-2H-pyran
110-87-2

3,4-dihydro-2H-pyran

6-furfurylaminopurine
525-79-1

6-furfurylaminopurine

6-furfurylamino-9-(tetrahydropyran-2-yl)-9H-purine
109403-64-7

6-furfurylamino-9-(tetrahydropyran-2-yl)-9H-purine

Conditions
ConditionsYield
With formic acid In ethyl acetate at 78℃; for 3h;80%
1-Bromo-2-chloroethane
107-04-0

1-Bromo-2-chloroethane

6-furfurylaminopurine
525-79-1

6-furfurylaminopurine

6-furfurylamino-9-(2-chloroethyl)purine
120593-23-9

6-furfurylamino-9-(2-chloroethyl)purine

Conditions
ConditionsYield
With potassium carbonate In dimethyl sulfoxide for 18h;80%
ethylene dibromide
106-93-4

ethylene dibromide

6-furfurylaminopurine
525-79-1

6-furfurylaminopurine

6-furfurylamino-9-(2-bromoethyl)purine
1309656-94-7

6-furfurylamino-9-(2-bromoethyl)purine

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl-formamide at 20℃; for 12h;60%
bromo-triphenyl-methane
596-43-0

bromo-triphenyl-methane

6-furfurylaminopurine
525-79-1

6-furfurylaminopurine

furane-2-ylmethyl-(9-trityl-9H-purine-6-yl)-amine
934244-37-8

furane-2-ylmethyl-(9-trityl-9H-purine-6-yl)-amine

Conditions
ConditionsYield
With triethylamine In N,N-dimethyl-formamide at 20 - 50℃;53%

525-79-1Relevant articles and documents

-

Hall,Ropp

, p. 6400 (1955)

-

Efficient Phosphorus-Free Chlorination of Hydroxy Aza-Arenes and Their Application in One-Pot Pharmaceutical Synthesis

Wang, Jian,Li, Yan-Hui,Pan, Song-Cheng,Li, Ming-Fang,Du, Wenting,Yin, Hong,Li, Jing-Hua

, p. 146 - 153 (2020/03/10)

The chlorination of hydroxy aza-arenes with bis(trichloromethyl) carbonate (BTC) and SOCl2 has been effectively performed by refluxing with 5 wt % 4-dimethylaminopyridine (DMAP) as a catalyst. Various substrates are chlorinated with high yields. The obtained chlorinated aza-arenes can be used directly with simple workup for succedent one-pot synthesis on a large scale.

Synthetic method for high-purity 6-furfurylaminopurine

-

Paragraph 0012-0014, (2018/12/14)

The invention discloses a synthetic method for high-purity 6-furfurylaminopurine. According to the synthetic method, in the existence of 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU), furfuryl amine and 6-chloropurine are subjected to nucleophilic substitution reaction under reflux condition of hexamethyldisilazane so as to obtain a crude product of 6-furfurylaminopurine, and recrystallizing is carriedout so as to obtain 6-furfurylaminopurine, the HPLC purity is 99.5% or above, and the any individual impurity content is less than 0. 1wt%. The synthetic method has the advantages of being simple inprocess, high in yield and free of wastewater discharge.

9-subsituted-N-(2-chlorobenzyl)purine-6-amine derivative, as well as preparation method and application thereof

-

Paragraph 0062; 0063; 0064; 0065; 0066; 0074; 0075, (2017/08/28)

The invention discloses a 9-subsituted-N-(2-chlorobenzyl)purine-6-amine derivative. The structure of the derivative is shown in a formula (I), where R is selected from a hydrogen atom, a C1-C4 alkyl group and a substituted or unsubstituted benzyl group, and a substituent on the benzyl group is one or more independently selected from halogen, -CF3, a C1-C4 alkoxy group, a C1-C4 alkyl group and a nitro group; R4 is a substituted or unsubstituted phenyl group or benzyl group, and a substituent on the phenyl group or the benzyl group is one or more of halogen and a methoxy group. Compared with a 6-benyl adenine compound complex gold ion (inhibitor 3), the 9-subsituted-N-(2-chlorobenzyl)purine-6-amine derivative is proved by testing results to have the advantages of higher inflammation factor inhibition rate, higher anti-inflammation activity and potential for use as an anti-inflammation medicament. (The formula (I) is shown in the description.).

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