525-79-1 Usage
Description
Different sources of media describe the Description of 525-79-1 differently. You can refer to the following data:
1. Kinetin (or Vivakin) was introduced as Kinerase in the US as a new
ingredient for the treatment of age related photodamage of skin. This 6-
furfurylaminopurine is a synthetic cytokinin, a family of plant growth factors, and
was shown to be a highly potent growth factor. In vitro, it was able to delay or
prevent the onset of age-related changes in skin cells without affecting cellular
lifespan. In a double-blind clinical trial, Kinetin (0.005%) partially reversed the
clinical signs of photodamaged skin and demonstrated a good safety profile.
It could have potential in psoriasis as well as in other proliferative skin disorders.
2. Kinetin is a cytokinin plant growth regulator with diverse biological activities. Kinetin (0.23 μM) increases p34cdc2-like histone H1 kinase activity, the number of cells in mitosis, and total cell number in arrested N. plumbaginifolia cells. It increases GSH levels and activity of glutathione peroxidase and glutathione reductase, but reduces thiobarbituric acid reactive substances (TBARS) levels, in human skin fibroblasts when used at a concentration of 10 μM. Kinetin (40 μM) reduces age-related enlargement, multinucleation, and accumulation of cellular debris in human mammary skin fibroblasts without affecting proliferative lifespan.
Chemical Properties
White Solid
Originator
Senetek (UK)
Uses
Different sources of media describe the Uses of 525-79-1 differently. You can refer to the following data:
1. auxin, plant growth regulator, plant cell division promotor
2. Plant growth accelerator
3. Plant growth regulator. To augment growth of microbial cultures: BE 632589 (1963 to Hoechst).
4. Kinetin acts as plant growth accelerator, auxin, plant growth regulator, plant cell division promotor. It also acts as cell division factor found in various plant parts and in yeast. A plant growth regulator. Augments growth of microbial cultures.
Brand name
Kinerase
Synthesis Reference(s)
The Journal of Organic Chemistry, 21, p. 1276, 1956 DOI: 10.1021/jo01117a016
General Description
Kinetin is an artificial?cytokinin, obtained from herring sperm. It is named due to its ability to stimulate cell division.
Biochem/physiol Actions
FAPα has in vitro dipeptidyl peptidase activity and collagenolytic activity. It cleaves N-terminal dipeptides from polypeptides and can degrade gelatin and type I collagen. It has also been reported that FAPa has a tumor suppressor activity.
Purification Methods
It forms platelets from EtOH and sublimes at 220o, but is best done at lower temperatures in a good vacuum. It has been extracted from neutral aqueous solutions with Et2O. [Miller et al J Am Chem Soc 78 1375 1956, Bullock et al. J Am Chem Soc 78 3693 1956, Beilstein 26 III/IV 3586.]
Check Digit Verification of cas no
The CAS Registry Mumber 525-79-1 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 5,2 and 5 respectively; the second part has 2 digits, 7 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 525-79:
(5*5)+(4*2)+(3*5)+(2*7)+(1*9)=71
71 % 10 = 1
So 525-79-1 is a valid CAS Registry Number.
525-79-1Relevant articles and documents
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Hall,Ropp
, p. 6400 (1955)
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Efficient Phosphorus-Free Chlorination of Hydroxy Aza-Arenes and Their Application in One-Pot Pharmaceutical Synthesis
Wang, Jian,Li, Yan-Hui,Pan, Song-Cheng,Li, Ming-Fang,Du, Wenting,Yin, Hong,Li, Jing-Hua
, p. 146 - 153 (2020/03/10)
The chlorination of hydroxy aza-arenes with bis(trichloromethyl) carbonate (BTC) and SOCl2 has been effectively performed by refluxing with 5 wt % 4-dimethylaminopyridine (DMAP) as a catalyst. Various substrates are chlorinated with high yields. The obtained chlorinated aza-arenes can be used directly with simple workup for succedent one-pot synthesis on a large scale.
Synthetic method for high-purity 6-furfurylaminopurine
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Paragraph 0012-0014, (2018/12/14)
The invention discloses a synthetic method for high-purity 6-furfurylaminopurine. According to the synthetic method, in the existence of 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU), furfuryl amine and 6-chloropurine are subjected to nucleophilic substitution reaction under reflux condition of hexamethyldisilazane so as to obtain a crude product of 6-furfurylaminopurine, and recrystallizing is carriedout so as to obtain 6-furfurylaminopurine, the HPLC purity is 99.5% or above, and the any individual impurity content is less than 0. 1wt%. The synthetic method has the advantages of being simple inprocess, high in yield and free of wastewater discharge.
9-subsituted-N-(2-chlorobenzyl)purine-6-amine derivative, as well as preparation method and application thereof
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Paragraph 0062; 0063; 0064; 0065; 0066; 0074; 0075, (2017/08/28)
The invention discloses a 9-subsituted-N-(2-chlorobenzyl)purine-6-amine derivative. The structure of the derivative is shown in a formula (I), where R is selected from a hydrogen atom, a C1-C4 alkyl group and a substituted or unsubstituted benzyl group, and a substituent on the benzyl group is one or more independently selected from halogen, -CF3, a C1-C4 alkoxy group, a C1-C4 alkyl group and a nitro group; R4 is a substituted or unsubstituted phenyl group or benzyl group, and a substituent on the phenyl group or the benzyl group is one or more of halogen and a methoxy group. Compared with a 6-benyl adenine compound complex gold ion (inhibitor 3), the 9-subsituted-N-(2-chlorobenzyl)purine-6-amine derivative is proved by testing results to have the advantages of higher inflammation factor inhibition rate, higher anti-inflammation activity and potential for use as an anti-inflammation medicament. (The formula (I) is shown in the description.).