52715-11-4

Upstream product

• 95-54-5 1,2-diamino-benzene 
• 98-74-8 4-Nitrobenzenesulfonyl chloride 
• 934-32-7 1H-benzimidazol-2-amine 
• 121-61-9 p-acetylaminobenzenesulfonamide 
• 149992-61-0 N-[4-(1,3-Dihydro-benzoimidazol-2-ylidenesulfamoyl)-phenyl]-acetamide 
• 615-28-1 o-phenylenediamine dihydrochloride 
• 408511-07-9 N-(2-amino-phenyl)-N'-(4-nitro-benzenesulfonyl)-guanidine 
• 859786-88-2 N-(2-amino-phenyl)-N'-(4-nitro-benzenesulfonyl)-urea 
• 29177-55-7 N-carbamoyl-4-nitrobenzenesulfonamide 
• 2651-14-1 Dimethyl N-(4-Aminophenylsulphonyl)dithiocarbonimidate 
• 193696-66-1 4-nitro-benzenesulfonic acid-(1H-benzimidazol-2-ylamide) 
• 2651-13-0 p-acetylaminobenzenesulphonyliminodithiocarbonic acid dimethyl ester 
• 4392-46-5 4-nitro-benzenesulfonic acid-cyanamide 

Relevant academic research and scientific papers

Synthesis and structure-activity relationship studies of 4-((2-hydroxy-3-methoxybenzyl)amino)benzenesulfonamide derivatives as potent and selective inhibitors of 12-lipoxygenase

Human lipoxygenases (LOXs) are a family of iron-containing enzymes which catalyze the oxidation of polyunsaturated fatty acids to provide the corresponding bioactive hydroxyeicosatetraenoic acid (HETE) metabolites. These eicosanoid signaling molecules are involved in a number of physiologic responses such as platelet aggregation, inflammation, and cell proliferation. Our group has taken a particular interest in platelet-type 12-(S)-LOX (12-LOX) because of its demonstrated role in skin diseases, diabetes, platelet hemostasis, thrombosis, and cancer. Herein, we report the identification and medicinal chemistry optimization of a 4-((2-hydroxy-3-methoxybenzyl)amino) benzenesulfonamide-based scaffold. Top compounds, exemplified by 35 and 36, display nM potency against 12-LOX, excellent selectivity over related lipoxygenases and cyclooxygenases, and possess favorable ADME properties. In addition, both compounds inhibit PAR-4 induced aggregation and calcium mobilization in human platelets and reduce 12-HETE in β-cells.

Functionalized azoles and triazolo[1,5-a]pyrimidines as latent leishmanicides

Triazolo[1,5-a]pyrimidine (3-6), benzoxazole (7a,b) and benzimidazole (7c) derivatives have been synthesized and evaluated for their in vitro leishmanicidal activity against L. donovani promastigotes.

Synthesis, antimicrobial and genotoxic properties of some benzoimidazole derivatives

A number of 1H-benzoimidazol-2-ylamine and of 1-methyl-1H- benzoimidazol-2-ylamine derivatives were synthesized and the crystal and molecular structure of N-[4-(2-amino-benzoimidazole-1-sulfonyl)-phenyl] acetamide was determined by X-ray diffraction analysis. The compounds obtained were investigated for antimicrobial and genotoxic activities.

Syhthesis of N4-substituted sulphanilamides and evaluation of their antibacterial efficacy

Pharmacologically active compounds belonging to the classes of p-thiocyano and p-aminobenzene sulphonamides have been synthesised and their antimicrobial activity evaluated against Gram + ve and Gram - ve bacteria.The compounds of both the classes show more inhibition of Gram -ve bacteria as compared to Gram + ve.