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52783-53-6

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52783-53-6 Usage

General Description

Methyl 3,5-O-di-t-butylsilylene-α-D-arabinofuranoside is a chemical compound that belongs to the class of arabinofuranosides, which are a type of glycoside. This particular compound is a derivative of the sugar arabinose, and it is modified with t-butylsilylene groups at the 3 and 5 positions. The t-butylsilylene groups are added to protect the hydroxyl groups of the arabinofuranoside, making it more stable and less reactive. methyl 3,5-O-di-t-butylsilylene-α-D-arabinofuranoside may be used in organic synthesis, especially in the preparation of other arabinofuranosides for various research and industrial purposes.

Check Digit Verification of cas no

The CAS Registry Mumber 52783-53-6 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,2,7,8 and 3 respectively; the second part has 2 digits, 5 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 52783-53:
(7*5)+(6*2)+(5*7)+(4*8)+(3*3)+(2*5)+(1*3)=136
136 % 10 = 6
So 52783-53-6 is a valid CAS Registry Number.

52783-53-6Relevant articles and documents

2-Hydroxyimino-6-aza-pyrimidine nucleosides: Synthesis, DFT calculations, and antiviral evaluations

Abou-Elkhair, Reham A. I.,Wasfy, Abdalla A.,Mao, Song,Du, Jinxi,Eladl, Sobhy,Metwally, Kamel,Hassan, Abdalla E. A.,Sheng, Jia

, p. 19650 - 19662 (2020/12/05)

The global public health concerns and economic impact caused by emerging outbreaks of RNA viruses call for the search for new direct acting antiviral agents. Herein, we describe the synthesis, DFT calculations, and antiviral evaluation of a series of novel 2-hydroxyimino-6-aza-pyrimidine ribonucleosides. DFT//B3LYP/6-311+G?? calculations of the tautomeric distributions of the 2-hydroxyimino nucleosides 7, 8, and 9 in aqueous environments indicate a predominance of the canonical 2-(E)-hydroxyimino structure, where the hydroxyl group points away from the sugar moiety. The conformer distributions of the latter geometrical isomers of 7, 8, and 9 support the formation of five membered rings via hydrogen bonding between the (E)-C2N-O-H moiety and N3-H of 7 and 8 and between (E)-C2N-O-H and N3 of 9, creating purine shaped nucleosides with the glycosidic linkage at the pyrimidine ring. The newly synthesized nucleosides were screened against an RNA viral panel, of which moderate antiviral activity was observed against Zika virus (ZIKV) and human respiratory syncytial virus (HRSV). 6-Aza-2-hydroxyimino-5-methyluridine derivative 18 showed activity against ZIKV (EC50 3.2 μM), while its peracetylated derivative 19 showed activity against HRSV (EC50 5.2 μM). The corresponding 4-thiono-2-hydroxyimino derivative 8 showed activity against HRSV (EC50 6.1 μM) and against ZIKA (EC50 2.4 μM). This study shows that the 6-aza-2-hydroxyimino-5-methyluracil derived nucleosides can be further optimized to provide potent antiviral agents. This journal is

Preparation of the tri-arabino di-mycolate fragment of mycobacterial arabinogalactan from defined synthetic mycolic acids

Mohammed, Mohsin O.,Al Dulayymi, Juma'a R.,Baird, Mark S.

supporting information, p. 36 - 42 (2016/11/25)

An efficient synthetic approach to tri-arabino di-mycolates, using structurally defined synthetic α-, keto and methoxy mycolic acids is described.

Automated solid phase synthesis of oligoarabinofuranosides

Kandasamy, Jeyakumar,Hurevich, Mattan,Seeberger, Peter H.

supporting information, p. 4453 - 4455 (2013/06/26)

Automated solid phase synthesis enables rapid access to the linear and branched arabinofuranoside oligosaccharides. A simple purification step is sufficient to provide the conjugation ready oligosaccharides in good yield.

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