52794-98-6

Basic information

• Product Name: D-3,4-DICHLOROPHENYLALANINE
• Synonyms: RARECHEM BK PT 0118;(R)-2-AMINO-3-(3,4-DICHLORO-PHENYL)-PROPIONIC ACID;3,4-DICHLORO-D-PHENYLALANINE;3,4-DICHLORO-D-PHE-OH;3,4-DICHLOROPHENYL-D-ALANINE;DICHLOROPHE;D-3,4-DICHLOROPHE;D-3,4-DICHLOROPHENYLALANINE
• CAS NO: 52794-98-6
• Molecular Formula: C₉H₉Cl₂NO₂
• Molecular Weight: 234.08
• Product Categories: Amino Acids;Phenylalanine analogs and other aromatic alpha amino acids;Unusual Amino Acids;Peptide;a-amino
• Mol File: 52794-98-6.mol

Chemical Properties

• Boiling Point: 370.6 °C at 760 mmHg
• Flash Point: 177.9 °C
• Appearance: /
• Density: 1.45 g/cm³
• Vapor Pressure: 3.78E-06mmHg at 25°C
• Refractive Index: 1.601
• Storage Temp.: Store at RT.
• PKA: 2.14±0.20(Predicted)
• CAS DataBase Reference: D-3,4-DICHLOROPHENYLALANINE(CAS DataBase Reference)
• NIST Chemistry Reference: D-3,4-DICHLOROPHENYLALANINE(52794-98-6)
• EPA Substance Registry System: D-3,4-DICHLOROPHENYLALANINE(52794-98-6)

Safety Data

• Hazard Codes: Xi
• Hazardous Substances Data: 52794-98-6(Hazardous Substances Data)

Usage

Uses

3,4-Dichloro-D-phenylalanine is used in the synthesis of human Pin1 inhibitors. It is also used to prepare morphiceptin analogs with μ-receptor binding activities in brain and mammary adenocarcinoma.

InChI:InChI=1/C9H9Cl2NO2/c10-6-2-1-5(3-7(6)11)4-8(12)9(13)14/h1-3,8H,4,12H2,(H,13,14)/t8-/m1/s1

Upstream product

• 5472-67-3 2-amino-3-(3,4-dichlorophenyl)propionic acid 

Downstream Products

• 183853-47-6 (R)-3-(3,4-Dichloro-phenyl)-2-phenylmethanesulfonylamino-propionic acid 
• 1227832-69-0 C₂₀H₁₅Cl₂NO₃ 
• 880347-78-4 (R)-2-amino-3-(3,4-dichloro-phenyl)-propionic acid methyl ester hydrochloride 
• 1027423-36-4 (S)-1-[(R)-3-(3,4-Dichloro-phenyl)-2-phenylmethanesulfonylamino-propionyl]-pyrrolidine-2-carboxylic acid methyl ester 
• 197893-18-8 N-benzylsulfonyl-D-(3,4-dichlorophenyl)alanyl-L-proline 

Relevant articles and documents

Enantioselective scavenging using homogenate of Rhodotorula graminis: a facile preparation of d-amino acid derivatives in enantiopure form

An enantioselective scavenger (ES) comprised homogenate of Rhodotorula graminis containing multiple enzymes can enantioselectively remove l-enantiomer in a racemic mixture of amino acid derivatives (AADs), yielding d-enantiomer in high ee. Thirteen non-proteinogenic AADs were produced in enantiopure d form. The method appears to be an efficient cleaning and preparative strategy which can be applied to the production of d-AADs in high ee by enantioselectively scavenging the 'l-contaminants'.