53002-05-4

Basic information

• Product Name: N-tritylpyridin-2-amine
• CAS NO: 53002-05-4
• Molecular Formula: C₂₄H₂₀N₂
• Molecular Weight: 336.429
• Mol File: 53002-05-4.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 476.9°C at 760 mmHg
• Flash Point: 242.2°C
• Density: 1.16g/cm³
• Vapor Pressure: 2.93E-09mmHg at 25°C
• Refractive Index: 1.658
• CAS DataBase Reference: N-tritylpyridin-2-amine(CAS DataBase Reference)
• NIST Chemistry Reference: N-tritylpyridin-2-amine(53002-05-4)
• EPA Substance Registry System: N-tritylpyridin-2-amine(53002-05-4)

Safety Data

• Hazardous Substances Data: 53002-05-4(Hazardous Substances Data)

Upstream product

• 504-29-0 2-aminopyridine 
• 76-84-6 triphenylmethyl alcohol 
• 76-83-5 trityl chloride 
• 596-43-0 bromo-triphenyl-methane 
• 18909-18-7 1-diphenylmethylene-4-trityl-2,5-cyclohexadiene 
• 341-02-6 trityl tetrafluoroborate 

Relevant articles and documents

Electrophilic tropylation of 2-aminopyridine

Electrophilic tropylation of 2-aminopyridine afforded N-(cyclohepta-2,4,6-trien-1-yl)pyridin-2-amine. The product was tested for antibacterial activity against Staphylococcus aureus no. 906 and Candida albicans ATSS 24 433.

Tritylamino aromatic heterocycles and related carbinols as blockers of Ca2+-activated potassium ion channels underlying neuronal hyperpolarization

A series of novel aromatic tritylamino heterocycles has been synthesized and the compounds have been tested in comparison with clotrimazole for their ability to inhibit the slow afterhyperpolarization current (SlAHP) in cultured rat hippocampal pyramidal neurones. Some analogues of the clotrimazole metabolite, 2-chlorophenyl-diphenyl methanol, having different chlorination substitution in the triphenyl group have also been examined. Two compounds in particular, 3-[(2-chlorophenyl)diphenylmethylamino]pyridine (3a, UCL 1880) and 2-tritylaminothiazole (6, UCL 2027), are of special interest; they are effective blockers of the SlAHP (IC50 = 1.1-1.2 μM) and are much more selective than clotrimazole since they have less effect on the high voltage-activated Ca2+ current.