5308-28-1

Basic information

• Product Name: N-Isobutyl piperazine
• Synonyms: N-ISOBUTYLPIPERAZINE;n-isobutyliperazine;IFLAB-BB F1929-1684;1-(2-METHYLPROPYL)-PIPERAZINE;1-ISOBUTYL-PIPERAZINE;1-(2-METHYLPROPYL)-PIPERAZINE, 1-ISOBUTYL-PIPERAZINE >98%;1-(2-METHYLPROPYL)-PIPERAZINE, 1-ISOBUTYL-PIPERAZINE;N-iso-Butyl piperazine 1-iso-Butylpiperazine
• CAS NO: 5308-28-1
• Molecular Formula: C₈H₁₈N₂
• Molecular Weight: 142.24
• Product Categories: Amines and Anilines;Piperaizine;piperazines
• Mol File: 5308-28-1.mol
• Article Data: 11

Chemical Properties

• Boiling Point: 65°C (10 mmHg)
• Flash Point: 57.1 °C
• Appearance: /
• Density: 0.864 g/cm³
• Vapor Pressure: 0.718mmHg at 25°C
• Refractive Index: 1.446
• Storage Temp.: 2-8°C(protect from light)
• PKA: 9.27±0.10(Predicted)
• CAS DataBase Reference: N-Isobutyl piperazine(CAS DataBase Reference)
• NIST Chemistry Reference: N-Isobutyl piperazine(5308-28-1)
• EPA Substance Registry System: N-Isobutyl piperazine(5308-28-1)

Safety Data

• Hazard Codes: Xi
• Statements: 41
• Safety Statements: 26-39
• HazardClass: IRRITANT
• Hazardous Substances Data: 5308-28-1(Hazardous Substances Data)

Usage

General Description

N-Isobutyl piperazine, also known as N,iBuPip, is a chemical compound commonly used as an intermediate in organic synthesis and pharmaceutical manufacturing. It is a piperazine derivative, featuring a six-membered heterocyclic ring with two nitrogen atoms. N-Isobutyl piperazine is a clear, colorless liquid with a slightly amine-like odor. It is used as a raw material for the production of various pharmaceuticals, including antiviral and antimicrobial drugs. N-Isobutyl piperazine is also used as a corrosion inhibitor and as a component in some pesticide formulations. It is considered to be relatively low in toxicity and has low potential for bioaccumulation.

InChI:InChI=1/C8H18N2/c1-8(2)7-10-5-3-9-4-6-10/h8-9H,3-7H2,1-2H3

Upstream product

• 110-85-0 piperazine 
• 78-77-3 Isobutyl bromide 
• 629625-93-0 benzyl 4-iso-butylpiperazine-1-carboxylate 
• 1026893-83-3 4-Isobutyl-piperazine-1-carboxylic acid tert-butyl ester 

Downstream Products

• 102535-28-4 3-(4-Isobutyl-piperazine-1-carbonyl)-4-methoxy-benzenesulfonamide 
• 129791-92-0 rifalazil 
• 77777-04-9 8-Benzylthio-2-(N-isobutyl-piperazino)-4-morpholino-pyrimido-[5,4-d]-pyrimidine 
• 1214265-89-0 N-(4-(4-i-butylpiperazin-1-yl)cyclohexyl)acetamide 
• 1245319-23-6 5-amino-2-(4-fluorophenyl)-7-(4-isobutylpiperazin-1-yl)-oxazolo[5,4-d]pyrimidine 
• 1260242-68-9 C₂₉H₃₃F₆N₇ 
• 1257432-85-1 1-(4-fluoro-benzenesulfonyl)-pyrrolidine-2S-carboxylic acid [2-(4-isobutyl-piperazin-1-yl)-6-(4-trifluoromethyl-phenyl)-pyrimidin-4-ylmethyl]-amide 
• 4649-58-5 2-(4-isobutyl-piperazin-1-yl)-ethylamine 
• 305379-88-8 1-{5-[4-(3,4-dichloro-phenyl)-1H-imidazol-2-yl]-pyridin-2-yl}-4-isobutyl-piperazine, hydrochloride 

Relevant articles and documents

Heteroaromatic acetamide derivative, preparation and applications thereof

The present invention provides a heteroaromatic acetamide derivative, a preparation and applications thereof, wherein the derivative comprises a pharmaceutically acceptable salt and/or a solvate thereof. According to the present invention, the experiment results prove that the heteroaromatic acetamide derivative can specifically bind to transient receptor potential ankyrin 1 (TRPA1) and inhibit orreduce the activity of TRPA1, and can be used for treating diseases mediated by TRPA1; and the inhibitor of the present invention further comprises a pharmaceutical composition of the compound, and amethods for preparing the compounds. The derivative has a general formula defined in the specification.

NOVEL PHYSIOLGICALLY ACTIVE SUBSTANCES

The present invention relates to a compound represented by the formula (I): (wherein, R3, R6, R7 and R21 are the same as or different from one another and each represents a hydroxyl group etc.), a pharmacologically acceptable salt thereof or a hydrate of them. The compound (I) of the present invention suppresses angiogenesis, in particular, suppresses VEGF production in a hypoxic condition and is useful as a therapeutic agent for treating solid cancer.

Pyridinecarboxamide derivatives

Pyridinecarboxamide derivatives of the formula STR1 (wherein n represents an integer of 14-18, and R represents a hydrogen atom or a straight or branched C1 -C4 alkyl group) or physiologically acceptable salts thereof. The compounds have excellent inhibiting activity of cerebral edema, especially ischemic cerebral edema, and inhibiting activity of delayed death of neuronal cells (an inhibiting activity of Ca-influx in neuronal cells). Cerebral edema is a pathologic condition accompanying cerebrovascular disorders, especially the acute stage of cerebrovascular disorders and then the compounds are useful as an agent for inhibiting cerebral edema or a therapeutic agent for cerebrovascular disorders. Moreover, the compounds have no hypotensive action which is considered to be side-effect in treating the acute stage cerebrovascular disorders and hardly show a behavior suppressing action so that they are an excellent therapeutic agent for, in particular, the acute stage cerebrovascular disorders. Moreover, the compounds show a cerebral protective activity (an anti-anoxic activity), an increasing activity of cerebral blood flow, and an inhibiting activity of lipid peroxidation and these activities may lead to the increased utility as a therapeutic agent for cerebrovascular disorders.