53120-76-6

Basic information

• Product Name: 1,5-Pentanediol, 3,3-dimethyl-, bis(4-methylbenzenesulfonate)
• CAS NO: 53120-76-6
• Molecular Formula: C21H28O6S2
• Molecular Weight: 440.582
• Mol File: 53120-76-6.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 1,5-Pentanediol, 3,3-dimethyl-, bis(4-methylbenzenesulfonate)(CAS DataBase Reference)
• NIST Chemistry Reference: 1,5-Pentanediol, 3,3-dimethyl-, bis(4-methylbenzenesulfonate)(53120-76-6)
• EPA Substance Registry System: 1,5-Pentanediol, 3,3-dimethyl-, bis(4-methylbenzenesulfonate)(53120-76-6)

Safety Data

• Hazardous Substances Data: 53120-76-6(Hazardous Substances Data)

Upstream product

• 53120-74-4 3,3-dimethylpent-1,5-diol 
• 98-59-9 p-toluenesulfonyl chloride 
• 4160-82-1 3,3-dimethylglutaric anhydride 
• 53120-75-5 3,3-dimethylglutaryl chloride 
• 110-94-1 1,5-pentanedioic acid 
• 4839-46-7 3,3-Dimethylglutaric acid 

Downstream Products

• 1192813-82-3 3,3-dimethyl-5-(2-(1-trityl-1H-imidazol-4-yl)phenoxy)pentyl 4-methylbenzene sulfonate 
• 1166394-48-4 C₂₅H₂₈O₈ 
• 1149748-39-9 C₂₀H₂₅NO₆S 
• 866750-99-4 toluene-4-sulfonic acid 5-(4'-chloro-biphenyl-4-yloxy)-3,3-dimethyl-pentyl ester 
• 37746-17-1 1,5-dibromo-3,3-dimethylpentane 

Relevant articles and documents

3-(5-HYDROXY-1-OXOISOINDOLIN-2-YL)PIPERIDINE-2,6-DIONE DERIVATIVES AND USES THEREOF

The present disclosure provides a compound of Formula (I′): or a pharmaceutically acceptable salt, hydrate, solvate, prodrug, stereoisomer, or tautomer thereof, wherein Rx, X1, X2, and R1 are as defined herein, and methods of making and using same.

Design, synthesis, and anti-HCV activity of thiourea compounds

A series of thiourea derivatives were synthesized and their antiviral activity was evaluated in a cell-based HCV subgenomic replicon assay. SAR studies revealed that the chain length and the position of the alkyl linker largely influenced the in vitro anti-HCV activity of this class of potent antiviral agents. Among this series of compounds synthesized, the thiourea derivative with a six-carbon alkyl linker at the meta-position of the central phenyl ring (10) was identified as the most potent anti-HCV inhibitor (EC50 = 0.047 μM) with a selectivity index of 596.

Synthesis and antipicornavirus activity of (R)- and (S)-1-[5-(4′- chlorobiphenyl-4-yloxy)-3-methylpentyl]-3-pyridin-4-yl-imidazolidin-2-one

The new pyridyl imidazolidinone derivative, 1-[5-(4′-chlorobiphenyl- 4-yloxy)-3-methylpentyl]-3-pyridin-4-yl-imidazolidin-2-one (±)-1a, was synthesized and found to have an excellent antiviral activity against EV71 (IC50 = 0.009 μM). Therefore, both the enantiomers, (S)-(+)-1a and (R)-(-)-1a, have been prepared starting from readily available monomethyl (R)-3-methylglutarate (7) as a useful chiral building block and their antiviral activity was evaluated in a plaque reduction assay. Interestingly, we observed that the enantiomer (S)-(+)-1a was 10-fold more active against enterovirus71 (EV71) (IC50 = 0.003 μM) than the corresponding enantiomer (R)-(-)-1a (IC50 = 0.033 μM). Similar results were found against all five strains (1743, 2086, 2231, 4643, and BrCr) of EV71 tested. This demonstrated that the absolute configuration of the chiral carbon atom at the 3-position of the alkyl linker considerably influenced the anti-EV71 activity of these pyridyl imidazolidinones.