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53154-02-2

53154-02-2

53154-02-2

Identification

Synonyms:(R)-2-Cyclohexyl-propionsaeure-nitril;

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Chemical Properties

  • PSA: 23.79000

  • LogP: 2.72638

Safety information and MSDS view more

  • Signal Word:no data available

  • Hazard Statement:no data available

  • First-aid measures: General adviceConsult a physician. Show this safety data sheet to the doctor in attendance.If inhaled If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician. In case of skin contact Wash off with soap and plenty of water. Consult a physician. In case of eye contact Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician. If swallowed Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.

  • Fire-fighting measures: Suitable extinguishing media Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide. Wear self-contained breathing apparatus for firefighting if necessary.

  • Accidental release measures: Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. For personal protection see section 8. Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided. Pick up and arrange disposal. Sweep up and shovel. Keep in suitable, closed containers for disposal.

  • Handling and storage: Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Avoid exposure - obtain special instructions before use.Provide appropriate exhaust ventilation at places where dust is formed. For precautions see section 2.2. Store in cool place. Keep container tightly closed in a dry and well-ventilated place.

  • Exposure controls/personal protection:Occupational Exposure limit valuesBiological limit values Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday. Eye/face protection Safety glasses with side-shields conforming to EN166. Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU). Skin protection Wear impervious clothing. The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace. Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique(without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it. Respiratory protection Wear dust mask when handling large quantities. Thermal hazards

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Relevant articles and documentsAll total 1 Articles be found

Oxidative Decyanation of Secondary Nitriles to Ketones

Freerksen, Robert W.,Selikson, Sandra J.,Wroble, Randall R.,Kyler, S. Keith,Watt, David S.

, p. 4087 - 4096 (2007/10/02)

Procedures for the oxidative decyanation of secondary nitriles to ketones involve (1) iodination of N-(trialkylsilyl)ketenimines derived from secondary nitriles and subsequent hydrolysis of the α-iodo nitriles with silver oxide, (2) addition of nitrosobenzene to N-(trialkylsilyl)ketenimines, (3) conversion of secondary nitriles to α-(phenylthio) nitriles and subsequent hydrolysis with N-bromosuccinimide in aqueous acetonitrile, and (4) preparation of α-hydroperoxy nitriles by direct oxygenation of anions of secondary nitriles and subsequent reductive hydrolysis with stannous chloride followed by sodium hydroxide.The latter general procedure was applied to various secondary nitriles bearing dialkyl, aryl and alkyl, and diaryl substituents to provide ketones in good yield and was extended to the oxidative decyanation of α,β-unsaturated nitriles to furnish α,β-unsaturated ketones.

Process route upstream and downstream products

Process route

2-cyclohexylidenepropanenitrile
53153-76-7

2-cyclohexylidenepropanenitrile

2-Cyclohexyl-propionitrile
53154-02-2

2-Cyclohexyl-propionitrile

Conditions
Conditions Yield
91%
With magnesium; In methanol;
(<i>R</i>)-2-cyclohexyl-propionic acid amide
28523-32-2

(R)-2-cyclohexyl-propionic acid amide

(<i>R</i>)-2-cyclohexyl-propionic acid nitrile
53154-02-2

(R)-2-cyclohexyl-propionic acid nitrile

Conditions
Conditions Yield
With phosphorus pentoxide; under 2 Torr;
(2R)-2-cyclohexylpropanoic acid
3451-36-3

(2R)-2-cyclohexylpropanoic acid

(<i>R</i>)-2-cyclohexyl-propionic acid nitrile
53154-02-2

(R)-2-cyclohexyl-propionic acid nitrile

Conditions
Conditions Yield
Multi-step reaction with 3 steps
1: thionyl chloride
2: ethanolic ammonia
3: phosphorus (V)-oxide / 2 Torr
With thionyl chloride; ammonia; phosphorus pentoxide;
2-Cyclohexyl-propionitrile
53154-02-2

2-Cyclohexyl-propionitrile

cinnamyl tert-butyl carbonate
124517-47-1

cinnamyl tert-butyl carbonate

C<sub>18</sub>H<sub>23</sub>N

C18H23N

C<sub>18</sub>H<sub>23</sub>N

C18H23N

Conditions
Conditions Yield
2-Cyclohexyl-propionitrile; With silver(I) bromide; lithium hexamethyldisilazane; In tetrahydrofuran; at 0 - 20 ℃; for 0.5h; Inert atmosphere;
With 1,3-bis[2,6-bis(diphenylmethyl)-4-methylphenyl]imidazol-2-ylidene hydrochloride; potassium tert-butylate; allylpalladium(II) chloride dimer; In tetrahydrofuran; at 0 - 20 ℃; for 0.5h;
cinnamyl tert-butyl carbonate; In tetrahydrofuran; at 20 ℃; for 12h; Overall yield = 48 percent;
2-Cyclohexyl-propionitrile
53154-02-2

2-Cyclohexyl-propionitrile

C<sub>14</sub>H<sub>22</sub>O<sub>3</sub>

C14H22O3

C<sub>18</sub>H<sub>27</sub>N

C18H27N

C<sub>18</sub>H<sub>27</sub>N

C18H27N

Conditions
Conditions Yield
2-Cyclohexyl-propionitrile; With silver(I) bromide; N,N,N,N,-tetramethylethylenediamine; lithium hexamethyldisilazane; In tetrahydrofuran; at 0 - 20 ℃; for 0.5h; Inert atmosphere;
With 1,3-bis[2,6-bis(diphenylmethyl)-4-methylphenyl]imidazol-2-ylidene hydrochloride; potassium tert-butylate; allylpalladium(II) chloride dimer; In tetrahydrofuran; at 0 - 20 ℃; for 0.5h;
C14H22O3; In tetrahydrofuran; at 20 ℃; for 12h; Overall yield = 80 percent;
2-Cyclohexyl-propionitrile
53154-02-2

2-Cyclohexyl-propionitrile

acetyl chloride
75-36-5

acetyl chloride

α-Peracetoxy-α-methylcyclohexylacetonitril
62623-58-9

α-Peracetoxy-α-methylcyclohexylacetonitril

Conditions
Conditions Yield
Multistep reaction; (i) nBuLi, iPr2NH, THF, hexane, (ii) O2, (iii) /BRN= 605303/;
2-Cyclohexyl-propionitrile
53154-02-2

2-Cyclohexyl-propionitrile

ethyl bromoacetate
105-36-2

ethyl bromoacetate

4-cyclohexyl-4-methyl-pyrrolidin-2-one
100400-33-7

4-cyclohexyl-4-methyl-pyrrolidin-2-one

Conditions
Conditions Yield
With sodium amide; benzene; und Hydrieren des Reaktionsprodukts an Raney-Nickel in Methanol bei 120grad/80at;

53154-02-2 Upstream products

53154-02-2 Downstream products

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