5317-33-9

Basic information

• Product Name: 1-(3-HYDROXYPROPYL)-4-METHYLPIPERAZINE
• Synonyms: 3-(4-METHYL-PIPERAZIN-1-YL)-PROPAN-1-OL;1-(3-HYDROXYPROPYL)-4-METHYLPIPERAZINE;N-METHYL-N'-(3 HYDROXYLPROPYL) PIPERAZINE;3-(4-methyl-1-piperazine)propan-1-ol;1-Piperazinepropanol,4-methyl-(6CI,7CI,8CI,9CI);1-(3-HYDROXYPROPYL)-4-METHYL-PIPERAZINE >98%;3-(4-Methylpiperazin-1-yl)-1-propanol;4-Methyl-1-piperazine-1-propanol
• CAS NO: 5317-33-9
• Molecular Formula: C8H18N2O
• Molecular Weight: 158.24
• EINECS: 226-177-6
• Product Categories: PIPERIDINE;pharmacetical;piperazines
• Mol File: 5317-33-9.mol
• Article Data: 20

Chemical Properties

• Melting Point: 30 °C
• Boiling Point: 75-78°C/0.5mm
• Flash Point: 111.6 °C
• Appearance: /
• Density: 0.988 g/cm³
• Vapor Pressure: 0.00294mmHg at 25°C
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility: Chloroform (Slightly)
• PKA: 15.10±0.10(Predicted)
• CAS DataBase Reference: 1-(3-HYDROXYPROPYL)-4-METHYLPIPERAZINE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(3-HYDROXYPROPYL)-4-METHYLPIPERAZINE(5317-33-9)
• EPA Substance Registry System: 1-(3-HYDROXYPROPYL)-4-METHYLPIPERAZINE(5317-33-9)

Safety Data

• Hazard Codes: Xi
• Statements: 36
• Safety Statements: 24/25-26
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 5317-33-9(Hazardous Substances Data)

Usage

Uses

4-Methyl-1-piperazinepropanol is a useful synthetic organic compound used in the synthesis of S-Alkyl-N-alkylisothiourea compounds.

InChI:InChI=1/C8H18N2O/c1-9-4-6-10(7-5-9)3-2-8-11/h11H,2-8H2,1H3/p+2

Upstream product

• 109-01-3 1-methyl-piperazine 
• 107-18-6 allyl alcohol 
• 5317-32-8 3-(1-piperazinyl)-1-propanol 
• 50-00-0 formaldehyd 
• 33544-40-0 methyl 3-(4-methylpiperazin-1-yl)propanoate 
• 7148-05-2 ethyl 3-(4-methylpiperazin-1-yl)propanoate 
• 627-18-9 1-bromo-3-propanol 
• 627-30-5 1-chloro-3-hydroxypropane 
• 66443-73-0 N-allyl-4-methylpiperazine 
• 55-86-7 mechlorethamine hydrochloride 
• 109-78-4 3-Hydroxypropionitrile 

Downstream Products

• 101873-08-9 3,4,5-trimethoxy-benzoic acid-[3-(4-methyl-piperazino)-propyl ester] 
• 63885-82-5 4-Aza-phenothiazin-10-carbonsaeure-1-N'-methyl-piperazino-propylester-3 
• 99007-12-2 3-Amino-1-benzyl-1H-pyrazole-4-carboxylic acid 3-(4-methyl-piperazin-1-yl)-propyl ester; compound with oxalic acid 
• 198961-81-8 4-[N-(3-methylphenyl)amino]-7-[3-(4-methyl-1-piperazinyl)propoxy]-6-nitroquinazoline 
• 492444-39-0 7-[3-(4-methylpiperazin-1-yl)propoxy]-6-methoxy-4-chloro-quinoline-3-carbonitrile 
• 753005-90-2 4-[(2,4-dichloro-5-methoxyphenyl)amino]-6-ethoxy-7-[3-(4-methylpiperazin-1-yl)propoxy]quinoline-3-carbonitrile 
• 894426-67-6 4-chloro-7-methoxy-6-[3-(4-methylpiperazin-1-yl)propoxy]quinazoline 
• 1092565-77-9 3-(4-methylpiperazin-1-yl)propyl [3-(5-methoxy-2-oxobenzooxazol-3-ylmethyl)phenyl]carbamate 
• 960299-67-6 3-fluoro-4-{6-methoxy-7-[3-(4-methylpiperazin-1-yl)propoxy]quinolin-4-yloxy}phenylamine 
• 1119204-84-0 3-(4-methylpiperazin-1-yl)propyl {3-[3-(3,5-difluorophenyl)-6-oxo-6H-pyridazin-1-ylmethyl]phenyl}carbamate 
• 1259031-92-9 N-[3-(4-methylpiperazin-1-yl)propyl]-N-(tert-butyldimethylsilyloxy)-4-methylbenzenesulfonamide 
• 1086389-74-3 5-(3-{3,5-difluoro-4-[3-(4-methylpiperazin-1-yl)propoxy]-phenyl}-6-oxo-6H-pyridazin-1-ylmethyl)-1,3-dihydrobenzimidazol-2-one 
• 288384-72-5 toluene-4-sulfonic acid 3-(4-methyl-piperazin-1-yl)-propyl ester 
• 103069-21-2 4-(2-Chloro-phenyl)-2-methyl-6-[3-(4-methyl-piperazin-1-yl)-propoxymethyl]-1,4-dihydro-pyridine-3,5-dicarboxylic acid 5-ethyl ester 3-methyl ester 

Relevant articles and documents

Manganese-Catalyzed Anti-Markovnikov Hydroamination of Allyl Alcohols via Hydrogen-Borrowing Catalysis

Controlling the selectivity in a hydroamination reaction is an extremely challenging yet highly desirable task for the diversification of amines. In this article, a selective formal anti-Markovnikov hydroamination of allyl alcohols is presented. It enables the versatile synthesis of valuable γ-amino alcohol building blocks. A phosphine-free Earth's abundant manganese(I) complex catalyzed the reaction under hydrogen-borrowing conditions. A vast range of aliphatic, aromatic amines, drug molecules, and natural product derivatives underwent successful hydroamination with primary and secondary allylic alcohols with excellent functional group tolerance (57 examples). The catalysis could be performed on a gram scale and has been applied for the synthesis of drug molecules. The mechanistic studies revealed the metal-ligand bifunctionality as well as hemilability of the ligand backbone as the key design principle for the success of this catalysis.

2-Arylbenzothiazole analogues and uses thereof in the treatment of cancer

The present invention relates to anticancer compounds of the general formula (I) and salts and physiologically functional derivatives thereof, wherein Y independently represents S, O, NR 2 , SO, SO 2 ; A independently represents a five- or six-membered aromatic carbocycle or heterocycle and wherein R 1 in formula (I) represents one of the heteroaryl groups defined in the claims.

2,5- and 2,6-disubstituted benzazole derivatives useful as protein kinase inhibitors

The present invention relates to compounds of the general formula (I) and salts and physiologically functional derivatives thereof, wherein the substituent is attached to the 5- or 6- position of the benzazole; Xindependently represents S, O, SO, SO2;Yindependently represents S, O, NR2, SO, SO2;Aindependently represents ←CO-, ←CS-, ←SO-, ←SO2-, ←CO2-, ←CONR8-, ←NR8CO-, ←NR8CONR9-, ←NR8COO-, ←NR8NR9CO-, ←NR8OCO-, ←ONR8CO-, ←NR8SO2-, where ← indicates the point of attachment to R3; and wherein R1 to R19 in formula (I) represent independently of each other a variety of different substituents comprising alkyl, aryl, aralkyl, alkylaryl, heteroaryl groups and monofunctional moieties. These compounds are useful as protein kinase inhibitors in the treatment of i.a. cancer.