5326-94-3Relevant articles and documents
Synthesis and anticoccidial activities of novel N-(2-Aminophenyl)-2- quinazolinone-acetamide hydrochloride
Yan, Chun-Rong,Yang, Li,Guo, A-Rong,Nie, Kui,Wang, Yu-Liang
, p. 4970 - 4974 (2013)
Eight novel N-(2-aminophenyl)-2-quinazolinone-acetamide hydrochloride were synthesized and their structures were identified by 1H NMR, MS and IR spectra. Seven of the new compounds were chosen for anticoccidial activity test and the results showed that N-(2- aminophenyl)-2-(6-methyl-8-bromo quinazolinone) acetamide hydrochloride (3h) exhibited anticoccidial activity against Eimeria tenella in the chicken' diet with a dose of 18 mg/Kg.
Facile synthesis, antimicrobial evaluation and molecular docking studies of pyrazole-imidazole-triazole hybrids
Deswal, Laxmi,Kumar, Ashwani,Kumar, Devinder,Punia, Suman,Verma, Vikas
, (2020/09/18)
A series of eighteen pyrazole-imidazole-triazole hybrid (2-(4-((2-(substituted-1H-pyrazol-1-yl)-4-phenyl-1H-imidazol-1-yl)methyl)-1H-1,2,3-triazol-1-yl)-N-(substituted)phenylacetami- de) (6a-6r) are synthesized through click reaction between in situ gener
Synthesis and antidiabetic evaluation of benzimidazole-tethered 1,2,3-triazoles
Deswal, Laxmi,Verma, Vikas,Kumar, Devinder,Kaushik, Chander?P.,Kumar, Ashwani,Deswal, Yogesh,Punia, Suman
, (2020/07/04)
Some novel benzimidazole-tethered 1,2,3-triazole derivatives (4a–r) were synthesized by a click reaction between 2-substituted 1-(prop-2-yn-1-yl)-1H-benzo[d]imidazole and in situ azide. The structures of the synthesized compounds were confirmed by spectroscopic studies (one- and two-dimensional nuclear magnetic resonance, Fourier transform infrared, and high-resolution mass spectra). The synthesized compounds were evaluated for their antidiabetic activity. Compounds 4a–r exhibited a good-to-moderate α-amylase and α-glucosidase inhibitory activity, with IC50 values ranging from 0.0410 to 0.0916 μmol/ml and 0.0146 to 0.0732 μmol/ml, respectively. Compounds 4e, 4g, and 4n were found to be most active. Furthermore, the binding conformation of the most active compounds was ascertained by docking studies.