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53267-01-9

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53267-01-9 Usage

Description

Cibenzoline is a structurally novel, class I (quinidine-like) antiarrhythmic agent. It has additional properties of class III and class IV compounds, delaying repolarization and antagonizing the positive inotropic effects of calcium.

Originator

Hexachemie (France)

Uses

Different sources of media describe the Uses of 53267-01-9 differently. You can refer to the following data:
1. Cibenzoline acts as a highly active class I antiarrhythmic agent.
2. Cardiac depressant.

Brand name

CIPRALAN

Check Digit Verification of cas no

The CAS Registry Mumber 53267-01-9 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,3,2,6 and 7 respectively; the second part has 2 digits, 0 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 53267-01:
(7*5)+(6*3)+(5*2)+(4*6)+(3*7)+(2*0)+(1*1)=109
109 % 10 = 9
So 53267-01-9 is a valid CAS Registry Number.
InChI:InChI=1/C18H18N2/c1-3-7-14(8-4-1)18(15-9-5-2-6-10-15)13-16(18)17-19-11-12-20-17/h1-10,16H,11-13H2,(H,19,20)

53267-01-9SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 17, 2017

Revision Date: Aug 17, 2017

1.Identification

1.1 GHS Product identifier

Product name Cibenzoline

1.2 Other means of identification

Product number -
Other names Cibenzolinum [inn-latin]

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:53267-01-9 SDS

53267-01-9Relevant articles and documents

NOVEL PROCESS FOR THE PREPARATION OF (+)-CIBENZOLINE SUCCINATE

-

Paragraph 204-208, (2020/05/12)

The present invention relates to a crystalline form of (+)-Cibenzoline succinate. The present invention is also related to a process for the preparation of (+)-Cibenzoline succinate with chiral purity greater than 99.9%. The present invention also provides a process for the preparation of (+)-Cibenzoline succinate and a crystalline form thereof.

Novel process for the synthesis of class I antiarrhythmic agent (±)-cibenzoline and its analogs

Gholap, Atul R.,Paul, Vincent,Srinivasan, Kumar V.

, p. 2967 - 2982 (2008/12/22)

Synthesis of (±)-cibenzoline and its analogs has been achieved by a simple sequence of reactions. The diaryl cyanoolefin intermediate 3 could be prepared by Knoevenagel condensation of benzophenone with ethylcyanoacetate to form the tetra-substituted olefin intermediate 2 followed by Krapcho deethoxycarbonylation or from β-hydroxynitrile intermediate 2' followed by the elimination of hydroxyl group respectively. The 2,2- diphenylcyclopropanecarbonitrile 4 was synthesized from intermediate 3 by cyclopropanation, which was converted to (±)-2-(2,2-diphenylcyclopropyl)- 2-imidazoline 5 by reaction with ethylenediamine in the presence of a catalytic amount of sulfur. Moreover, the obtained 2-imidazolines were smoothly oxidized to the corresponding imidazoles 6 in good to moderate yields. Copyright Taylor & Francis Group, LLC.

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