53292-90-3

Basic information

• Product Name: CIS-4-(BOC-AMINO)CYCLOHEXANECARBOXYLIC ACID
• Synonyms: cis-1-(t-butyloxycarbonyl-amino)-cyclohexyl-4-carboxylicacid;(1s,4s)-4-(tert-butoxycarbonylamino)cyclohexanecarboxylic acid;trans-4-tert-butoxycarbonylaMinocyclohexane-1-ylcarboxylic acid;cis-4-[(tert-Butyloxycarbonyl)amino]cyclohexanecarboxylic acid;cis-4-[[[(1,1-Dimethylethyl)oxy]carbonyl]amino]cyclohexanecarboxylic acid;cis-4-tert-Butoxycarbonylamino-1-cyclohexanecarboxylic acid;N-BOC-cis-4-Aminocyclohexane-1-carboxylic acid;cis-4-(tert-Butoxycarbonylamino)cyclohexanecarboxylic Acid
• CAS NO: 53292-90-3
• Molecular Formula: C₁₂H₂₁NO₄
• Molecular Weight: 243.3
• Product Categories: Alicyclic Amino Acids;Peptide Synthesis;Unnatural Amino Acid Derivatives
• Mol File: 53292-90-3.mol
• Article Data: 27

Chemical Properties

• Melting Point: 169°C(lit.)
• Boiling Point: 396.698 °C at 760 mmHg
• Flash Point: 193.716 °C
• Appearance: White to off-white/Powder
• Density: 1.13 g/cm³
• Vapor Pressure: 2.12E-07mmHg at 25°C
• Refractive Index: 1.493
• Storage Temp.: 2-8°C
• PKA: 4.89±0.25(Predicted)
• BRN: 7641071
• CAS DataBase Reference: CIS-4-(BOC-AMINO)CYCLOHEXANECARBOXYLIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: CIS-4-(BOC-AMINO)CYCLOHEXANECARBOXYLIC ACID(53292-90-3)
• EPA Substance Registry System: CIS-4-(BOC-AMINO)CYCLOHEXANECARBOXYLIC ACID(53292-90-3)

Safety Data

• Statements: 36/37/38
• Safety Statements: 26-36
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 53292-90-3(Hazardous Substances Data)

Usage

Chemical Properties

White powder

InChI:InChI=1/C12H21NO4/c1-12(2,3)17-11(16)13-9-6-4-8(5-7-9)10(14)15/h8-9H,4-7H2,1-3H3,(H,13,16)(H,14,15)/t8-,9+

Upstream product

• 1776-53-0 4-aminocyclohexanecarboxylic acid 
• 24424-99-5 di-tert-butyl dicarbonate 
• 150-13-0 4-amino-benzoic acid 
• 3685-23-2 cis-4-aminocyclohexane-1-carboxylic acid 
• 17159-79-4 ethyl 4-oxocyclohexane-1-carboxylate 
• 6297-22-9 4-carbomethoxycyclohexanone 
• 38446-95-6 4-oxocyclohexanecarboxylic acid tert-butyl ester 
• 400899-07-2 methyl (1r,4r)‐4‐{[(tert‐butoxy)carbonyl](methyl)amino}cyclohexane‐1‐carboxylate 
• 881657-40-5 tert-butyl ((3R,6S)-6-formyltetrahydro-2H-pyran-3-yl)carbamate 
• 603130-12-7 1,5-anhydro-2-[(tert-butoxycarbonyl)amino]-2,3,4-trideoxy-D-erythro-hexitol 
• 146307-51-9 methyl (1R,4R)-4-((tert-butoxycarbonyl)amino)cyclohexane-1-carboxylate 
• 1776-53-0 trans-4-aminocyclohexanecarboxylic acid 

Downstream Products

• 133075-92-0 N<carbonyl>phenylalanine benzyl ester 
• 944404-27-7 [trans-4-(4-isopropyl-piperazine-1-carbonyl)-cyclohexyl]-carbamic acid tert-butyl ester 
• 509143-03-7 cis-(4-tert-butoxycarbonylamino-cyclohexyl)-carbamic acid benzyl ester 
• 615568-05-3 C₂₁H₂₈N₄O₄ 
• 1607794-68-2 allyl trans-4-aminocyclohexanoate hydrochloride 
• 1607794-77-3 allyl trans-4-(tert-butoxycarbonylamino)cyclohexanoate 
• 374088-22-9 {4-[3-(5-hydroxy-1H-indol-3-yl)-8-aza-bicyclo[3.2.1]oct-8-ylmethyl]-cyclohexyl}-carbamic acid tert-butyl ester 
• 374088-23-0 3-[(1S,3S,5R)-8-(4-Amino-cyclohexylmethyl)-8-aza-bicyclo[3.2.1]oct-3-yl]-1H-indol-5-ol 
• 181308-56-5 t-butyl (cis-4-formylcyclohexyl)carbamate 
• 878395-72-3 4-amino-cyclohexanecarboxylic acid [2-(cyclopentanecarbonyl-amino)-benzothiazol-6-yl]-amide 
• 400899-17-4 methanesulfonic acid 5-[4-(tert-butoxycarbonyl-methyl-amino)-cyclohexyl]-pentyl ester 

Relevant articles and documents

PYRIMIDINYL GROUP-CONTAINING TRICYCLIC COMPOUND SERVING AS C-MET INHIBITOR

Disclosed are a pyrimidinyl group-containing tricyclic compound and applications thereof in preparing a cancer-treating medicament. Specifically disclosed are a compound as represented by formula (I), a pharmaceutically acceptable salt of same, or an isomer thereof.

Preparation method of trans 4 - (tert-butyloxycarbonylamino) cyclohexanecarboxylic acid and intermediate thereof

The invention provides a preparation method of trans 4 - (tert-butyloxycarbonylamino) cyclohexanecarboxylic acid and an intermediate thereof. The preparation method is characterized by comprising the following steps of 4 - oxocyclohexane carboxylic ester and chiral ligand reagent tert-butyl sulfinamide as a raw material, reducing amination to obtain trans -4 -tert-butyl sulfinyl sulfenamide cyclohexane carboxylic acid ester by virtue of chiral ligand reagent tert-butyl sulfinamide and 4 - 95% -oxocyclohexane carboxylic ester, and is stable in basic conditions and easy to leave under an acidic condition. Reaction conditions are mild, operation is simple and convenient, yield is high, and industrial production is easy.

Compound serving as protein kinase inhibitor and application of compound

The invention discloses a compound used as a protein kinase inhibitor and application of the compound, the compound has an obvious inhibition effect on protein kinase activity, can be used as a BTK inhibitor for preparing medicines for treating BTK-mediated diseases such as malignant tumors, autoimmune diseases and the like, and has wide application prospect.