53399-38-5

Basic information

• Product Name: thieno[2,3-b]pyridine-3-carbonitrile
• Synonyms: thieno[2,3-b]pyridine-3-carbonitrile
• CAS NO: 53399-38-5
• Molecular Formula: C8H4N2S
• Molecular Weight: 160.19576
• Mol File: 53399-38-5.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• CAS DataBase Reference: thieno[2,3-b]pyridine-3-carbonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: thieno[2,3-b]pyridine-3-carbonitrile(53399-38-5)
• EPA Substance Registry System: thieno[2,3-b]pyridine-3-carbonitrile(53399-38-5)

Safety Data

• Hazardous Substances Data: 53399-38-5(Hazardous Substances Data)

Upstream product

• 28988-21-8 3-bromanylthieno[2,3-b]pyridine 
• 272-23-1 thieno[2,3-b]pyridine 
• 143-33-9 sodium cyanide 
• 544-92-3 copper(I) cyanide 
• 26579-54-4 3-aminothieno[2,3-b]pyridine 

Downstream Products

• 53174-99-5 thieno[2,3-b]pyridine-3-carbaldehyde 

Relevant articles and documents

NEW ANALOGS AS ANDROGEN RECEPTOR AND GLUCOCORTICOID RECEPTOR MODULATORS

The present invention relates to novel dihydropyridine derivatives of formula (I): as modulators of nuclear receptors selected from androgen receptor and glucocorticoid receptor, to processes for their preparation, to pharmaceutical compositions comprising said compounds and to the use of said for manufacturing a medicament for the treatment of pathological conditions or diseases that can improve by modulation of androgen receptor and/or glucocorticoid receptor, selected from cancer, metastasizing cancers, benign prostate hyperplasia, polycystic ovary syndrome (PCOS), hair loss, hirsutism, acne, hypogonadism, muscle wasting diseases, cachexia, Cushing's syndrome, anti-psychotic drug induced weight gain, obesity, post-traumatic stress disorder and alcoholism.

CERTAIN TRIAZOLOPYRIDINES AND TRIAZOLOPYRAZINES, COMPOSITIONS THEREOF AND METHODS OF USE THEREFOR

Provided are certain triazolopyridines and triazolopyrazines, compositions thereof and methods of use therefor.

Synthesis and antidiabetic activity of 2,5-disubstituted-3-imidazol-2-yl-pyrrolo[2,3-b]pyridines and thieno[2,3-b]pyridines

In the present investigation, two series of 2,5-disubstituted-3-imidazol-2-yl-pyrrolo[2,3-b]pyridines (2a-l) and thieno[2,3-b]pyridines (3a-l) were designed as analogs of BL 11282 (1). The in vitro glucose dependent insulinotropic activity of all the test compounds was evaluated using RIN5F cell based assay and all the test compounds showed glucose and concentration dependent insulin secretion. The in vivo antidiabetic activities of most potent compounds from each series (2c and 3c) were assessed in C57BL/6J mice. Compounds 2c and 3c showed dose dependent insulin secretion and significant glucose reduction in vivo. In general, compounds 2c and 3c were found to be equipotent at all the three different doses selected and with respect to BL 11282, both the test compounds were found to be more potent, at all the time points.