5340-88-5

Basic information

• Product Name: BUTYL PYRIDINE-2-CARBOXYLATE
• Synonyms: N-BUTYL PICOLINATE;BUTYL PYRIDINE-2-CARBOXYLATE;BUTYL 2-PYRIDINECARBOXYLATE;2-Pyridinecarboxylic acid butyl ester;Butyl picolinate;Picolinic acid butyl ester;Pyridine-2-carboxylic acid butyl ester;picolin butyl ester
• CAS NO: 5340-88-5
• Molecular Formula: C₁₀H₁₃NO₂
• Molecular Weight: 179.22
• EINECS: 226-281-1
• Mol File: 5340-88-5.mol
• Article Data: 17

Chemical Properties

• Boiling Point: 276.8°Cat760mmHg
• Flash Point: 121.2°C
• Appearance: /
• Density: 1.053g/cm³
• Vapor Pressure: 0.00469mmHg at 25°C
• Refractive Index: 1.499
• CAS DataBase Reference: BUTYL PYRIDINE-2-CARBOXYLATE(CAS DataBase Reference)
• NIST Chemistry Reference: BUTYL PYRIDINE-2-CARBOXYLATE(5340-88-5)
• EPA Substance Registry System: BUTYL PYRIDINE-2-CARBOXYLATE(5340-88-5)

Safety Data

• Hazardous Substances Data: 5340-88-5(Hazardous Substances Data)

Usage

General Description

Butyl pyridine-2-carboxylate, also known as 2-pyridinecarboxylic acid butyl ester, is a chemical compound that belongs to the pyridine carboxylate ester family. It is commonly used as a flavoring agent in the food and beverage industry and as a fragrance ingredient in cosmetic and personal care products. It is a clear, colorless liquid with a fruity, floral odor. Butyl pyridine-2-carboxylate is also used as a chemical intermediate in the synthesis of pharmaceuticals, agrochemicals, and other organic compounds. It is considered to be a relatively safe compound with low toxicity, but proper handling and storage are recommended to avoid potential hazards.

InChI:InChI=1/C10H13NO2/c1-2-3-8-13-10(12)9-6-4-5-7-11-9/h4-7H,2-3,8H2,1H3

Upstream product

• 109-09-1 2-chloropyridine 
• 201230-82-2 carbon monoxide 
• 71-36-3 butan-1-ol 
• 109-04-6 2-bromo-pyridine 
• 1121-60-4 pyridine-2-carbaldehyde 
• 109-65-9 1-bromo-butane 
• 98-98-6 2-Picolinic acid 
• 13463-40-6 iron pentacarbonyl 
• 59576-30-6 2-methyl-1-(pyridin-2-yl)propan-1-one 
• 26501-54-2 tetrabutylammonium nitrite 
• 29952-04-3 2,2'-dipyridylketone monomethyliodide 
• 121529-94-0 Pyridine-2-aldehyde acetal 
• 636-80-6 2-picolinic acid hydrochloride 

Downstream Products

• 1452-63-7 picolinic acid hydrazide 
• 18904-38-6 N-benzyl-2-pyridinecarboxamide 
• 120-48-9 butyl p-nitrobenzoate 

Relevant articles and documents

Preparation of Carbamates, Esters, Amides, and Unsymmetrical Ureas via Br?nsted Acid-Activated N-Acyl Imidazoliums

We report the application of Br?nsted acid-activated N-acyl imidazoliums as versatile intermediates in carbonyl transformations. The efficient and scalable procedure was validated on a diverse set of carbamates, esters, amides, and unsymmetrical ureas (21 examples, up to 91% yield). Additionally, we exemplify this method on multikilogram scale for the synthesis of an electron-deficient carbamate.

Practical: In situ -generation of phosphinite ligands for palladium-catalyzed carbonylation of (hetero)aryl bromides forming esters

An effective method for alkoxycarbonylation of (hetero)aryl bromides is developed in the presence of in situ-generated phosphinite ligands tBu2POR (R = nBu, nPr, Et or Me). For this purpose commercially available tBu2PCl was used as the pre-ligand in the presence of different alcohols. For the first time cross coupling reactions with two alcohols-one generating the ligand, the other used as substrate-were developed. Through this method, ligand optimization can be performed in a more efficient manner and the desired products could be obtained with good yields and selectivity.

Synthesis and structures of 1,2,4-triazoles derivatives

Abstract A series of novel 1,2,4-triazole derivatives were synthesized, and their structures were characterized by IR, UV-Vis, FL, NMR, ESI-MS, and elemental analysis. In the meanwhile, the single crystal structures of 3,4-diethyl-5-(4-pyridyl)-1,2,4-triazole and 3,4-dimethyl-5-(o-hydroxyphenyl)-1,2,4-triazole were determined by X-ray diffraction.