53553-14-3

Basic information

• Product Name: METHYL 2-CHLORO-3-NITROBENZOATE
• Synonyms: METHYL 2-CHLORO-3-NITROBENZOATE;Benzoic acid, 2-chloro-3-nitro-, methyl ester
• CAS NO: 53553-14-3
• Molecular Formula: C₈H₆ClNO₄
• Molecular Weight: 215.59
• Product Categories: Aromatic Esters
• Mol File: 53553-14-3.mol
• Article Data: 31

Chemical Properties

• Boiling Point: 319.531 °C at 760 mmHg
• Flash Point: 147.047 °C
• Appearance: /
• Density: 1.427 g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.568
• Storage Temp.: 2-8°C
• CAS DataBase Reference: METHYL 2-CHLORO-3-NITROBENZOATE(CAS DataBase Reference)
• NIST Chemistry Reference: METHYL 2-CHLORO-3-NITROBENZOATE(53553-14-3)
• EPA Substance Registry System: METHYL 2-CHLORO-3-NITROBENZOATE(53553-14-3)

Safety Data

• Hazardous Substances Data: 53553-14-3(Hazardous Substances Data)

Usage

General Description

Methyl 2-chloro-3-nitrobenzoate is a chemical compound with the molecular formula C8H6ClNO4. It is a yellow crystalline substance that is used as an intermediate in the synthesis of various organic chemicals, including pharmaceuticals and agrochemicals. METHYL 2-CHLORO-3-NITROBENZOATE is primarily used in the production of other chemicals and does not have many direct applications of its own. Methyl 2-chloro-3-nitrobenzoate is known to have hazardous properties, and proper safety measures should be taken when handling it.

InChI:InChI=1/C8H6ClNO4/c1-14-8(11)5-3-2-4-6(7(5)9)10(12)13/h2-4H,1H3

Upstream product

• 3970-35-2 2-chloro-3-nitrobezoic acid 
• 18107-18-1 diazomethyl-trimethyl-silane 
• 67-56-1 methanol 
• 34128-16-0 2-chloro-3-nitro-benzoyl chloride 
• 79-37-8 oxalyl dichloride 
• 75-09-2 dichloromethane 
• 247903-17-9 3-(3-carbomethoxy-2-chloroanilino)cyclohex-2-en-1-one 
• 2622-14-2 tricyclohexylphosphine 
• 1445-45-0 Trimethyl orthoacetate 

Downstream Products

• 74683-28-6 2',3-dicarbomethoxy-5-hydroxy-6'-nitrodiphenyl ether 
• 227466-50-4 methyl 2-(methylthio)-3-nitrobenzoate 
• 328546-65-2 9-nitro-1,2,3,4-tetrahydro-5H-1,4-benzodiazepin-5-one 
• 254745-48-7 2-(4-bromo-benzylamino)-3-nitro-benzoic acid methyl ester 
• 1173978-61-4 [9-chloro-1-(2,4-dichlorophenyl)-1,2,3,4-tetrahydropyrimido[1,2-a]benzimidazol-6-yl]methanol 
• 1173980-66-9 1-[9-chloro-1-(2,4-dichlorophenyl)-1,2,3,4-tetrahydropyrimido[1,2-a]benzimidazol-6-yl]-2,2,2-trifluoroethanol 
• 1173981-04-8 methyl 1-(4-bromo-2-methylphenyl)-9-chloro-1,2,3,4-tetrahydropyrimido[1,2-a]benzimidazole-6-carboxylate 
• 1173981-05-9 [9-chloro-1-(4-bromo-2-methylphenyl)-1,2,3,4-tetrahydropyrimido[1,2-a]benzimidazol-6-yl]methanol 
• 1173981-06-0 9-chloro-1-(4-bromo-2-methylphenyl)-1,2,3,4-tetrahydropyrimido[1,2-a]benzimidazole-6-carbaldehyde 
• 1173981-07-1 1-[1-(4-bromo-2-methylphenyl)-9-chloro-1,2,3,4-tetrahydropyrimido[1,2-a]benzimidazol-6-yl]-2,2,2-trifluoroethanol 
• 1173981-09-3 9-chloro-6-[1-(difluoromethoxy)-2,2,2-trifluoroethyl]-1-(4-methoxy-2-methylphenyl)-1,2,3,4-tetrahydropyrimido[1,2-a]benzimidazole 
• 1173985-19-7 C₁₉H₁₈Cl₃N₃O₅S 
• 1173983-71-5 methyl 3-amino-2-[(3-hydroxypropyl)amino]benzoate 
• 1173983-84-0 methyl 3-amino-4-chloro-2-[(3-hydroxypropyl)amino]benzoate 

Relevant articles and documents

From off-to on-target: New BRAF-inhibitor-template-derived compounds selectively targeting mitogen activated protein kinase kinase 4 (MKK4)

The mitogen-activated protein kinase (MAP) kinase 4 (MKK4) was found to be a major regulator of liver regeneration and could be a valuable drug target addressing liver related diseases by restoring its intrinsic regenerative capacity. We report on the synthesis and optimization of novel MKK4 inhibitors following a target-hopping strategy from the FDA-approved BRAFV600E inhibitor PLX4032 (8). Applying an iterative multi-parameter optimization process we carved out essential structural features yielding in compounds with a low nanomolar affinity for MKK4 and excellent selectivity profiles against the main off-targets MKK7 and JNK1, which, upon relevant inhibition, would totally abrogate the pro-regenerative effect of MKK4 inhibition, as well as against the off-targets MAP4K5, ZAK and BRAF with selectivity factors ranging from 40 to 430 for our best-balanced compounds 70 and 73.

COMPOUNDS, COMPOSITIONS AND METHODS OF USE

Herein, compounds, compositions and methods for modulating inclusion formation and stress granules in cells related to the onset of neurodegenerative diseases, musculoskeletal diseases, cancer, ophthalmological diseases, and viral infections are described.

PROTEIN KINASE INHIBITORS FOR PROMOTING LIVER REGENERATION OR REDUCING OR PREVENTING HEPATOCYTE DEATH

The invention relates to MKK4 (mitogen-activated protein kinase 4) and their use in promoting liver regeneration or reducing or preventing hepatocyte death. The MKK4 inhibitors selectively inhibit protein kinase MKK4 over protein kinases JNK and MKK7.