53560-33-1Relevant articles and documents
Synthesis and biological evaluation of 1-(benzofuran-3-yl)-4-(3,4,5-trimethoxyphenyl)-1H-1,2,3-triazole derivatives as tubulin polymerization inhibitors
Qi, Zhi-Yuan,Hao, Shu-Yi,Tian, Heng-Zhi,Bian, Hong-Li,Hui, Ling,Chen, Shi-Wu
, (2020)
The key functions of microtubules and the mitotic spindle in cell division make them attractive targets for cancer therapy. In this study, a series of 1-(benzofuran-3-yl)-4-(3,4,5-trimethoxyphenyl)-1H-1,2,3-triazole derivatives was synthesized, and their
De Novo Synthesis of Tricyclic 5,5-Benzannulated Spiroketals
Rao, Maddali L. N.,Islam, Sk Shamim
, p. 3944 - 3948 (2021/05/29)
The synthesis of tricyclic 5,5-benzannulated spiroketal scaffolds was accomplished from 2′-hydroxyacetophenones and gem-dibromoalkenes involving a one-pot domino strategy. The hitherto unknown transformation afforded the tricyclic 5,5-benzannulated spirok
Copper-catalyzed domino synthesis of ynamines
Dasgupta, Priyabrata,Islam, Sk Shamim,Rao, Maddali L. N.
, p. 7855 - 7860 (2021/09/28)
The hitherto unexploredN-alkynylation of electron-withdrawing or protecting group free N-heteroarenes such as indole, carbazole and pyrrole was developed usinggem-dibromoalkenes to synthesize ynamines under ligand-free copper-catalyzed domino conditions. The development methodology of ynamines was also applied in the synthesis of enynamines, multi-coupled bis-ynamines, tris-ynamines, and the natural product peyonine, demonstrating its broad synthetic scope and applications.